28 June 2019

Tiziana Life Sciences plc

("Tiziana" or the "Company")

Change of Adviser

Tiziana Life Sciences plc (Nasdaq: TLSA / AIM: TILS), a UK biotechnology company that focuses on the discovery and development of novel molecules to treat human disease in oncology and immunology, announces the appointment of Shore Capital Stockbrokers Limited as Broker, with immediate effect. This follows the acquisition of Stockdale Securities Limited by Shore Capital Markets Limited.

For further enquiries:

Tiziana Life Sciences plc                                                                          +44 (0)20 7493 2853

Gabriele Cerrone, Chairman and founder                               

Cairn Financial Advisers LLP (Nominated adviser)                            +44 (0)20 7213 0883

Liam Murray / Jo Turner