NOTIFICATION OF MAJOR INTEREST IN SHARES

Press Release

June 8, 2017 at 10:02 AM BST

TR-1: NOTIFICATIONOFMAJORINTERESTINSHARESi

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached: ii		TIZIANA LIFE SCIENCES PLC
2 Reason for the notification (please tick the appropriate box or boxes):
An acquisition or disposal of voting rights			✔
An acquisition or disposal of qualifying financial instruments which may result in the acquisition of shares already issued to which voting rights are attached
An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments
An event changing the breakdown of voting rights
Other (please specify):
3. Full name of person(s) subject to the notification obligation: iii	PLANWISE GROUP LIMITED
4. Full name of shareholder(s) (if different from 3.):iv
5. Date of the transaction and date on which the threshold is crossed or reached: v	8/6/2017
6. Date on which issuer notified:	8/6/2017
7. Threshold(s) that is/are crossed or reached: vi, vii	60, 61, 62, 63, 64, 65, 66

8. Notified details:
A: Voting rights attached to shares viii, ix
Class/type of shares if possible using the ISIN CODE	Situation previous to the triggering transaction		Resulting situation after the triggering transaction
	Number of Shares	Number of Voting Rights	Number of shares	Number of voting rights		% of voting rights x
			Direct	Direct xi	Indirect xii	Direct	Indirect
	56,205,322	56,205,322	63,680,404	63,680,404		66.20

B: Qualifying Financial Instruments
Resulting situation after the triggering transaction
Type of financial	Expiration	Exercise/	Number of voting	% of voting
instrument	date xiii	Conversion Period xiv	rights that may be	rights
			acquired if the
			instrument is
			exercised/ converted.

9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable: ^xxi

N/A

Proxy Voting:
10. Name of the proxy holder:
11. Number of voting rights proxy holder will cease to hold:
12. Date on which proxy holder will cease to hold voting rights:

13. Additional information:

14. Contact name:

E. J. Lukins, Cooley (UK) LLP,

Dashwood, 69 Old Broad Street, London EC2M 1QS

15. Contact telephone number:

020 7556 4261

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments

xv, xvi

Resulting situation after the triggering transaction

Type of financial instrument

Exercise price

Expiration date xvii

Exercise/ Conversion period xviii

Number of voting rights instrument refers to

% of voting rights xix, xx