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Press Release

Exercise of Warrants & Issue of Equity

October 30, 2015 at 7:00 AM GMT

Released : Oct 30, 2015

RNS Number : 9377D

Tiziana Life Sciences PLC

30 October 2015




Exercise of Warrants & Issue of Equity


London, 30 October 2015 - Tiziana Life Sciences plc (AIM: TILS, the "Company"), the clinical stage biotechnology company focused on targeted drugs to treat diseases in oncology and immunology, announces that it has received a notification from warrant holders to exercise warrants over 58,222 ordinary shares in the Company at an exercise price of 150p per share, providing the Company with gross proceeds of £87,333.


Application will be made to the London Stock Exchange to admit the 58,222 new ordinary shares to trading on AIM.  Admission of the new ordinary shares is expected to occur on or around 5 November 2015.  The new ordinary shares will rank pari passu with the existing ordinary shares.


Following the issue of shares detailed above the so enlarged issued share capital of the Company will comprise 92,392,150 ordinary shares of 3p each.




Tiziana Life Sciences plc

Gabriele Cerrone, Chairman

+44 (0)20 7493 2853


Cairn Financial Advisers LLP (Nominated adviser)

Liam Murray / Avi Robinson

+44 (0)20 7148 7900


Beaufort Securities Limited (Broker)

Saif Janjua

+44 (0)20 7382 8300


FTI Consulting

Simon Conway / Rob Winder / Natalie Garland-Collins


+44 (0)20 3727 1000

About Tiziana Life Sciences

Tiziana Life Sciences plc is a UK biotechnology company that focuses on the discovery and development of novel molecules that treat human disease in oncology and immunology.


In January 2015, the Company entered into an exclusive license from Nerviano Medical Sciences relating to milciclib, a molecule which blocks the action of specific enzymes called cyclin-dependent kinases (CDK) involved in cell division as well as a number of other protein kinases.  Milciclib is currently in phase II clinical trials for thymic carcinoma in patients previously treated with chemotherapy.


The Company also in-licensed another clinical asset in December 2014 from Novimmune.  Foralumab is the only fully human engineered anti-human CD3 antibody in clinical development. This phase II asset has potential application in a wide range of autoimmune and inflammatory diseases, such as multiple sclerosis, type-1 diabetes (T1D), inflammatory bowel disease (IBD), psoriasis and rheumatoid arthritis, where modulation of a T-cell response is desirable.


Tiziana Life Sciences' research team has discovered that Bcl-3 has a prominent role in the metastasis of mammary cancers, and has elucidated the mechanism of Bcl-3 action to be a regulator of cancer cell motility. Tiziana has also determined that Bcl-3 inhibition suppresses cell motility in triple-negative, HER-2-positive PR- and ER-positive breast cancer sub-types, suggesting that Bcl-3 may be a master regulator of this metastatic property not only in aggressive breast cancers, but across the clinical spectrum of breast disease.


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