<?xml version="1.0" encoding="US-ASCII"?>
<!-- Generated by Broadridge Transform (tm) - http://www.broadridge.com -->
<!-- Created: Fri May 01 18:54:06 UTC 2026 -->
<xs:schema elementFormDefault="qualified" xmlns:srt-types="http://fasb.org/srt-types/2025" xmlns:tlsa="http://tizianalifesciences.com/20251231" targetNamespace="http://tizianalifesciences.com/20251231" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:dtr1="http://www.xbrl.org/dtr/type/2022-03-31" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:us-types="http://fasb.org/us-types/2025" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:dtr="http://www.xbrl.org/dtr/type/2024-01-31" xmlns:xbrli="http://www.xbrl.org/2003/instance">
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xlink:type="simple" xlink:href="tlsa-20251231_lab.xml" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef"/>
      <link:linkbaseRef xlink:type="simple" xlink:href="tlsa-20251231_pre.xml" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef"/>
      <link:linkbaseRef xlink:type="simple" xlink:href="tlsa-20251231_def.xml" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef"/>
      <link:linkbaseRef xlink:type="simple" xlink:href="tlsa-20251231_cal.xml" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef"/>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ConsolidatedBalanceSheet" id="tlsa_r_ConsolidatedBalanceSheet">
        <link:definition>995301 - Statement - Consolidated Balance Sheets</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ConsolidatedBalanceSheet_Parentheticals" id="tlsa_r_ConsolidatedBalanceSheet_Parentheticals">
        <link:definition>995302 - Statement - Consolidated Balance Sheets (Parentheticals)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ConsolidatedIncomeStatement" id="tlsa_r_ConsolidatedIncomeStatement">
        <link:definition>995303 - Statement - Consolidated Statements of Operations and Comprehensive Loss</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ShareholdersEquityType2or3" id="tlsa_r_ShareholdersEquityType2or3">
        <link:definition>995304 - Statement - Consolidated Statements of Shareholders&#8217; Equity</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ConsolidatedCashFlow" id="tlsa_r_ConsolidatedCashFlow">
        <link:definition>995305 - Statement - Consolidated Statements of Cash Flows</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/GeneralInformation" id="tlsa_r_GeneralInformation">
        <link:definition>995306 - Disclosure - General Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/AccountingPolicies" id="tlsa_r_AccountingPolicies">
        <link:definition>995307 - Disclosure - Accounting Policies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/CriticalAccountingJudgement" id="tlsa_r_CriticalAccountingJudgement">
        <link:definition>995308 - Disclosure - Critical Accounting Judgement</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/OperatingLoss" id="tlsa_r_OperatingLoss">
        <link:definition>995309 - Disclosure - Operating Loss</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/SegmentalReporting" id="tlsa_r_SegmentalReporting">
        <link:definition>995310 - Disclosure - Segmental Reporting</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/Employees" id="tlsa_r_Employees">
        <link:definition>995311 - Disclosure - Employees</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/RemunerationofKeyManagementPersonnel" id="tlsa_r_RemunerationofKeyManagementPersonnel">
        <link:definition>995312 - Disclosure - Remuneration of Key Management Personnel</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/FinanceOtherIncomeRevenueandCosts" id="tlsa_r_FinanceOtherIncomeRevenueandCosts">
        <link:definition>995313 - Disclosure - Finance/Other Income Revenue and Costs</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/Taxation" id="tlsa_r_Taxation">
        <link:definition>995314 - Disclosure - Taxation</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/LossPerShare" id="tlsa_r_LossPerShare">
        <link:definition>995315 - Disclosure - Loss Per Share</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/OtherReceivables" id="tlsa_r_OtherReceivables">
        <link:definition>995316 - Disclosure - Other Receivables</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ShareCapitalandSharePremium" id="tlsa_r_ShareCapitalandSharePremium">
        <link:definition>995317 - Disclosure - Share Capital and Share Premium</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ShareBasedPayments" id="tlsa_r_ShareBasedPayments">
        <link:definition>995318 - Disclosure - Share Based Payments</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/Reserves" id="tlsa_r_Reserves">
        <link:definition>995319 - Disclosure - Reserves</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/FinancialInstruments" id="tlsa_r_FinancialInstruments">
        <link:definition>995320 - Disclosure - Financial Instruments</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/CapitalRiskManagement" id="tlsa_r_CapitalRiskManagement">
        <link:definition>995321 - Disclosure - Capital Risk Management</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/TradeandOtherPayables" id="tlsa_r_TradeandOtherPayables">
        <link:definition>995322 - Disclosure - Trade and Other Payables</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/DeferredIncome" id="tlsa_r_DeferredIncome">
        <link:definition>995323 - Disclosure - Deferred Income</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/InvestmentinRelatedParty" id="tlsa_r_InvestmentinRelatedParty">
        <link:definition>995324 - Disclosure - Investment in Related Party</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/TreasuryShares" id="tlsa_r_TreasuryShares">
        <link:definition>995325 - Disclosure - Treasury Shares</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/RelatedPartyTransactions" id="tlsa_r_RelatedPartyTransactions">
        <link:definition>995326 - Disclosure - Related Party Transactions</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/Leases" id="tlsa_r_Leases">
        <link:definition>995327 - Disclosure - Leases</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/FinancialCommitments" id="tlsa_r_FinancialCommitments">
        <link:definition>995328 - Disclosure - Financial Commitments</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ContingentLiabilities" id="tlsa_r_ContingentLiabilities">
        <link:definition>995329 - Disclosure - Contingent Liabilities</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/SubsequentEvents" id="tlsa_r_SubsequentEvents">
        <link:definition>995330 - Disclosure - Subsequent Events</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/AccountingPoliciesByPolicy" id="tlsa_r_AccountingPoliciesByPolicy">
        <link:definition>996000 - Disclosure - Accounting Policies, by Policy (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/AccountingPoliciesTables" id="tlsa_r_AccountingPoliciesTables">
        <link:definition>996001 - Disclosure - Accounting Policies (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/OperatingLossTables" id="tlsa_r_OperatingLossTables">
        <link:definition>996002 - Disclosure - Operating Loss (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/EmployeesTables" id="tlsa_r_EmployeesTables">
        <link:definition>996003 - Disclosure - Employees (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/RemunerationofKeyManagementPersonnelTables" id="tlsa_r_RemunerationofKeyManagementPersonnelTables">
        <link:definition>996004 - Disclosure - Remuneration of Key Management Personnel (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/FinanceOtherIncomeRevenueandCostsTables" id="tlsa_r_FinanceOtherIncomeRevenueandCostsTables">
        <link:definition>996005 - Disclosure - Finance/Other Income Revenue and Costs (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/TaxationTables" id="tlsa_r_TaxationTables">
        <link:definition>996006 - Disclosure - Taxation (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/LossPerShareTables" id="tlsa_r_LossPerShareTables">
        <link:definition>996007 - Disclosure - Loss Per Share (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/OtherReceivablesTables" id="tlsa_r_OtherReceivablesTables">
        <link:definition>996008 - Disclosure - Other Receivables (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ShareCapitalandSharePremiumTables" id="tlsa_r_ShareCapitalandSharePremiumTables">
        <link:definition>996009 - Disclosure - Share Capital and Share Premium (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ShareBasedPaymentsTables" id="tlsa_r_ShareBasedPaymentsTables">
        <link:definition>996010 - Disclosure - Share Based Payments (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/FinancialInstrumentsTables" id="tlsa_r_FinancialInstrumentsTables">
        <link:definition>996011 - Disclosure - Financial Instruments (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/TradeandOtherPayablesTables" id="tlsa_r_TradeandOtherPayablesTables">
        <link:definition>996012 - Disclosure - Trade and Other Payables (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/DeferredIncomeTables" id="tlsa_r_DeferredIncomeTables">
        <link:definition>996013 - Disclosure - Deferred Income (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/InvestmentinRelatedPartyTables" id="tlsa_r_InvestmentinRelatedPartyTables">
        <link:definition>996014 - Disclosure - Investment in Related Party (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/LeasesTables" id="tlsa_r_LeasesTables">
        <link:definition>996015 - Disclosure - Leases (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/AccountingPoliciesDetails" id="tlsa_r_AccountingPoliciesDetails">
        <link:definition>996016 - Disclosure - Accounting Policies (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ScheduleofEstimatedUsefulLivesfortheCurrentPeriodandtheComparativePeriodTable" id="tlsa_r_ScheduleofEstimatedUsefulLivesfortheCurrentPeriodandtheComparativePeriodTable">
        <link:definition>996017 - Disclosure - Accounting Policies - Schedule of Estimated Useful Lives for the Current Period and the Comparative Period (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ScheduleofOperatingLossesTable" id="tlsa_r_ScheduleofOperatingLossesTable">
        <link:definition>996018 - Disclosure - Operating Loss - Schedule of Operating Losses (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ScheduleofEmployeesTable" id="tlsa_r_ScheduleofEmployeesTable">
        <link:definition>996019 - Disclosure - Employees - Schedule of Employees (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/RemunerationofKeyManagementPersonnelDetails" id="tlsa_r_RemunerationofKeyManagementPersonnelDetails">
        <link:definition>996020 - Disclosure - Remuneration of Key Management Personnel (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ScheduleofKeyManagementPersonnelTable" id="tlsa_r_ScheduleofKeyManagementPersonnelTable">
        <link:definition>996021 - Disclosure - Remuneration of Key Management Personnel - Schedule of Key Management Personnel (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ScheduleofShareOptionsandRestrictedStockAwardsWereGrantedTable" id="tlsa_r_ScheduleofShareOptionsandRestrictedStockAwardsWereGrantedTable">
        <link:definition>996022 - Disclosure - Remuneration of Key Management Personnel - Schedule of Share Options and Restricted Stock Awards Were Granted (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ScheduleofFinanceCostsTable" id="tlsa_r_ScheduleofFinanceCostsTable">
        <link:definition>996023 - Disclosure - Finance/Other Income Revenue and Costs - Schedule of Finance Costs (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/TaxationDetails" id="tlsa_r_TaxationDetails">
        <link:definition>996024 - Disclosure - Taxation (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ScheduleofTaxationTable" id="tlsa_r_ScheduleofTaxationTable">
        <link:definition>996025 - Disclosure - Taxation - Schedule of Taxation (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ScheduleofTaxationTable_Parentheticals" id="tlsa_r_ScheduleofTaxationTable_Parentheticals">
        <link:definition>996026 - Disclosure - Taxation - Schedule of Taxation (Parentheticals) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ScheduleofBasicLossPerShareTable" id="tlsa_r_ScheduleofBasicLossPerShareTable">
        <link:definition>996027 - Disclosure - Loss Per Share - Schedule of Basic Loss Per Share (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ScheduleofOtherReceivablesTable" id="tlsa_r_ScheduleofOtherReceivablesTable">
        <link:definition>996028 - Disclosure - Other Receivables - Schedule of Other Receivables (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ShareCapitalandSharePremiumDetails" id="tlsa_r_ShareCapitalandSharePremiumDetails">
        <link:definition>996029 - Disclosure - Share Capital and Share Premium (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ScheduleofShareCapitalArisingontheShareforShareExchangeTable" id="tlsa_r_ScheduleofShareCapitalArisingontheShareforShareExchangeTable">
        <link:definition>996030 - Disclosure - Share Capital and Share Premium - Schedule of Share Capital Arising on the Share for Share Exchange (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ShareBasedPaymentsDetails" id="tlsa_r_ShareBasedPaymentsDetails">
        <link:definition>996031 - Disclosure - Share Based Payments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ScheduleofShareOptionPlanTable" id="tlsa_r_ScheduleofShareOptionPlanTable">
        <link:definition>996032 - Disclosure - Share Based Payments - Schedule of Share Option Plan (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ScheduleofShareOptionsExpiryDatesandExercisePriceTable" id="tlsa_r_ScheduleofShareOptionsExpiryDatesandExercisePriceTable">
        <link:definition>996033 - Disclosure - Share Based Payments - Schedule of Share Options Expiry Dates and Exercise Price (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ScheduleofShareBasedPaymentTransactionsTable" id="tlsa_r_ScheduleofShareBasedPaymentTransactionsTable">
        <link:definition>996034 - Disclosure - Share Based Payments - Schedule of Share - Based Payment Transactions (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ScheduleofRestrictedStockUnitTable" id="tlsa_r_ScheduleofRestrictedStockUnitTable">
        <link:definition>996035 - Disclosure - Share Based Payments - Schedule of Restricted Stock Unit (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ScheduleofEstimatedtheFairValueofWarrantsTable" id="tlsa_r_ScheduleofEstimatedtheFairValueofWarrantsTable">
        <link:definition>996036 - Disclosure - Share Based Payments - Schedule of Estimated the Fair Value of Warrants (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ScheduleofFinancialLiabilitiesBasedonContractualUndiscountedPaymentsTable" id="tlsa_r_ScheduleofFinancialLiabilitiesBasedonContractualUndiscountedPaymentsTable">
        <link:definition>996037 - Disclosure - Financial Instruments - Schedule of Financial Liabilities Based on Contractual Undiscounted Payments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ScheduleofAllOtherVariablesRemainConstantTable" id="tlsa_r_ScheduleofAllOtherVariablesRemainConstantTable">
        <link:definition>996038 - Disclosure - Financial Instruments - Schedule of All Other Variables Remain Constant (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ScheduleofAllOtherVariablesRemainConstantTable_Parentheticals" id="tlsa_r_ScheduleofAllOtherVariablesRemainConstantTable_Parentheticals">
        <link:definition>996039 - Disclosure - Financial Instruments - Schedule of All Other Variables Remain Constant (Parentheticals) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ScheduleofTradeandOtherPayablesTable" id="tlsa_r_ScheduleofTradeandOtherPayablesTable">
        <link:definition>996040 - Disclosure - Trade and Other Payables - Schedule of Trade and Other Payables (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ScheduleofDeferredIncomeTable" id="tlsa_r_ScheduleofDeferredIncomeTable">
        <link:definition>996041 - Disclosure - Deferred Income - Schedule of Deferred Income (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/InvestmentinRelatedPartyDetails" id="tlsa_r_InvestmentinRelatedPartyDetails">
        <link:definition>996042 - Disclosure - Investment in Related Party (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ScheduleofInvestmentinRelatedPartyTable" id="tlsa_r_ScheduleofInvestmentinRelatedPartyTable">
        <link:definition>996043 - Disclosure - Investment in Related Party - Schedule of Investment in Related Party (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/TreasurySharesDetails" id="tlsa_r_TreasurySharesDetails">
        <link:definition>996044 - Disclosure - Treasury Shares (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/RelatedPartyTransactionsDetails" id="tlsa_r_RelatedPartyTransactionsDetails">
        <link:definition>996045 - Disclosure - Related Party Transactions (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ScheduleofRightofUseAssetsandLeaseLiabilitiesTable" id="tlsa_r_ScheduleofRightofUseAssetsandLeaseLiabilitiesTable">
        <link:definition>996046 - Disclosure - Leases - Schedule of Right-of-Use Assets and Lease Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ScheduleofConsolidatedStatementofFinancialTable" id="tlsa_r_ScheduleofConsolidatedStatementofFinancialTable">
        <link:definition>996047 - Disclosure - Leases - Schedule of Consolidated Statement of Financial (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/ScheduleofFutureMinimumLeasePaymentsTable" id="tlsa_r_ScheduleofFutureMinimumLeasePaymentsTable">
        <link:definition>996048 - Disclosure - Leases - Schedule of Future Minimum Lease Payments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/FinancialCommitmentsDetails" id="tlsa_r_FinancialCommitmentsDetails">
        <link:definition>996049 - Disclosure - Financial Commitments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/SubsequentEventsDetails" id="tlsa_r_SubsequentEventsDetails">
        <link:definition>996050 - Disclosure - Subsequent Events (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
      <link:roleType roleURI="http://tizianalifesciences.com/role/DocumentAndEntityInformation" id="DocumentAndEntityInformation">
        <link:definition>000 - Document - Document And Entity Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
  <xs:import namespace="http://fasb.org/us-types/2025" schemaLocation="https://xbrl.fasb.org/us-gaap/2025/elts/us-types-2025.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/2024-01-31" schemaLocation="https://www.xbrl.org/dtr/type/2024-01-31/types.xsd"/>
  <xs:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd"/>
  <xs:import namespace="http://fasb.org/srt-types/2025" schemaLocation="https://xbrl.fasb.org/srt/2025/elts/srt-types-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/sic/2025" schemaLocation="https://xbrl.sec.gov/sic/2025/sic-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/cyd-af/2025" schemaLocation="https://xbrl.sec.gov/cyd/2025/cyd-af-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/ecd/2025" schemaLocation="https://xbrl.sec.gov/ecd/2025/ecd-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/ecd-sub/2025" schemaLocation="https://xbrl.sec.gov/ecd/2025/ecd-sub-2025.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/dei-sub/2025" schemaLocation="https://xbrl.sec.gov/dei/2025/dei-sub-2025.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/2022-03-31" schemaLocation="https://www.xbrl.org/dtr/type/2022-03-31/types.xsd"/>
  <xs:element name="ConsolidatedStatementsOfShareholdersEquityAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ConsolidatedStatementsOfShareholdersEquityAbstract"/>
  <xs:element name="ScheduleOfEstimatedUsefulLivesForTheCurrentPeriodAndTheComparativePeriodAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfEstimatedUsefulLivesForTheCurrentPeriodAndTheComparativePeriodAbstract"/>
  <xs:element name="ScheduleOfOperatingLossesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfOperatingLossesAbstract"/>
  <xs:element name="ScheduleOfEmployeesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfEmployeesAbstract"/>
  <xs:element name="ScheduleOfKeyManagementPersonnelAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfKeyManagementPersonnelAbstract"/>
  <xs:element name="ScheduleOfShareOptionsAndRestrictedStockAwardsWereGrantedAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfShareOptionsAndRestrictedStockAwardsWereGrantedAbstract"/>
  <xs:element name="ScheduleOfFinanceCostsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfFinanceCostsAbstract"/>
  <xs:element name="ScheduleOfOtherReceivablesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfOtherReceivablesAbstract"/>
  <xs:element name="ScheduleOfShareOptionPlanAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfShareOptionPlanAbstract"/>
  <xs:element name="ScheduleOfShareOptionsExpiryDatesAndExercisePriceAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfShareOptionsExpiryDatesAndExercisePriceAbstract"/>
  <xs:element name="ScheduleOfShareBasedPaymentTransactionsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfShareBasedPaymentTransactionsAbstract"/>
  <xs:element name="ScheduleOfRestrictedStockUnitAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfRestrictedStockUnitAbstract"/>
  <xs:element name="ScheduleOfEstimatedTheFairValueOfWarrantsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfEstimatedTheFairValueOfWarrantsAbstract"/>
  <xs:element name="ScheduleOfFinancialLiabilitiesBasedOnContractualUndiscountedPaymentsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfFinancialLiabilitiesBasedOnContractualUndiscountedPaymentsAbstract"/>
  <xs:element name="ScheduleOfAllOtherVariablesRemainConstantAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfAllOtherVariablesRemainConstantAbstract"/>
  <xs:element name="ScheduleOfTradeAndOtherPayablesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfTradeAndOtherPayablesAbstract"/>
  <xs:element name="ScheduleOfInvestmentInRelatedPartyAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfInvestmentInRelatedPartyAbstract"/>
  <xs:element name="ScheduleOfFutureMinimumLeasePaymentsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfFutureMinimumLeasePaymentsAbstract"/>
  <xs:element name="UnlabeledAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_UnlabeledAbstract"/>
  <xs:element name="UnlabeledAbstract0" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_UnlabeledAbstract0"/>
  <xs:element name="StaffCostsComprisedAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_StaffCostsComprisedAbstract"/>
  <xs:element name="GroupAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_GroupAbstract"/>
  <xs:element name="FinanceIncomeAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_FinanceIncomeAbstract"/>
  <xs:element name="FinanceExpenseAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_FinanceExpenseAbstract"/>
  <xs:element name="GroupAbstract0" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_GroupAbstract0"/>
  <xs:element name="TheTaxChargeForTheYearIsDifferentFromTheStandardRateOfCorporationTaxInTheUnitedKingdomOf25TheDifferenceCanBeReconciledAsFollowsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_TheTaxChargeForTheYearIsDifferentFromTheStandardRateOfCorporationTaxInTheUnitedKingdomOf25TheDifferenceCanBeReconciledAsFollowsAbstract"/>
  <xs:element name="UnlabeledAbstract1" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_UnlabeledAbstract1"/>
  <xs:element name="UnlabeledAbstract2" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_UnlabeledAbstract2"/>
  <xs:element name="UnlabeledAbstract3" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_UnlabeledAbstract3"/>
  <xs:element name="UnlabeledAbstract4" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_UnlabeledAbstract4"/>
  <xs:element name="UnlabeledAbstract5" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_UnlabeledAbstract5"/>
  <xs:element name="UnlabeledAbstract6" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_UnlabeledAbstract6"/>
  <xs:element name="UnlabeledAbstract7" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_UnlabeledAbstract7"/>
  <xs:element name="PrepaymentsandOtherReceivablesCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_PrepaymentsandOtherReceivablesCurrent"/>
  <xs:element name="TaxationReceivable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_TaxationReceivable"/>
  <xs:element name="InvestmentsInRelatedParty" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_InvestmentsInRelatedParty"/>
  <xs:element name="OtherLiabilitieCurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_OtherLiabilitieCurrent"/>
  <xs:element name="ShareBasedPaymentReserveWarrants" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareBasedPaymentReserveWarrants"/>
  <xs:element name="RestrictedStocksUnitReserve" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_RestrictedStocksUnitReserve"/>
  <xs:element name="IssuanceOfShareCapital" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="tlsa_IssuanceOfShareCapital"/>
  <xs:element name="ShareCapitalOutstanding" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareCapitalOutstanding"/>
  <xs:element name="GainonSaleOfInvestment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_GainonSaleOfInvestment"/>
  <xs:element name="IncomeTaxSCredit" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_IncomeTaxSCredit"/>
  <xs:element name="ShareBasedPaymentoptions" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareBasedPaymentoptions"/>
  <xs:element name="OptionsForfeitedcancelled" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_OptionsForfeitedcancelled"/>
  <xs:element name="WarrantsExercisedInTheYear" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_WarrantsExercisedInTheYear"/>
  <xs:element name="WarrantsForfeitedInTheYear" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_WarrantsForfeitedInTheYear"/>
  <xs:element name="SharesToBeIssuedInLieuOfDirectorsFeesAndCashBonus" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_SharesToBeIssuedInLieuOfDirectorsFeesAndCashBonus"/>
  <xs:element name="OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation1" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation1"/>
  <xs:element name="OptionsExercisedInTheYear" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_OptionsExercisedInTheYear"/>
  <xs:element name="NetSharesToBeIssuedForATM" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_NetSharesToBeIssuedForATM"/>
  <xs:element name="NetSharesToBeIssuedForFundraising" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_NetSharesToBeIssuedForFundraising"/>
  <xs:element name="RSUReserveRestrictedShares" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_RSUReserveRestrictedShares"/>
  <xs:element name="SharesIssuedInLieuOfDirectorsFeesBonusAndExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_SharesIssuedInLieuOfDirectorsFeesBonusAndExpenses"/>
  <xs:element name="SharesIssuedInLieuOfFees" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_SharesIssuedInLieuOfFees"/>
  <xs:element name="AdjustmentsForSharebasedPaymentsWarrants" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_AdjustmentsForSharebasedPaymentsWarrants"/>
  <xs:element name="OptionsForfeitedDuringTheYear" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_OptionsForfeitedDuringTheYear"/>
  <xs:element name="FVLossOnInvestment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_FVLossOnInvestment"/>
  <xs:element name="DepreciationOfRightofuseAsset" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_DepreciationOfRightofuseAsset"/>
  <xs:element name="CashInflowFromTaxation" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_CashInflowFromTaxation"/>
  <xs:element name="InterestReceivedFromLoan" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_InterestReceivedFromLoan"/>
  <xs:element name="NetIncreaseInRelatedPartyReceivables" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_NetIncreaseInRelatedPartyReceivables"/>
  <xs:element name="NetIncreaseInRelatedPartyPayables" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_NetIncreaseInRelatedPartyPayables"/>
  <xs:element name="NetIncreasedecreaseInDeferredRevenue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_NetIncreasedecreaseInDeferredRevenue"/>
  <xs:element name="InvestmentInRelatedParty" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_InvestmentInRelatedParty"/>
  <xs:element name="SaleOfOkyoShares" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_SaleOfOkyoShares"/>
  <xs:element name="PurchaseOfTreasuryAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_PurchaseOfTreasuryAmount"/>
  <xs:element name="FundraisingCost" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_FundraisingCost"/>
  <xs:element name="ProceedsFromIssuanceOfOptions" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ProceedsFromIssuanceOfOptions"/>
  <xs:element name="RepaymentOfLeasingLiabilities" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_RepaymentOfLeasingLiabilities"/>
  <xs:element name="DisclosureOfAccountingShareCapitalAndSharePremiumtextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_DisclosureOfAccountingShareCapitalAndSharePremiumtextBlock"/>
  <xs:element name="InvestmentInRelatedPartyTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_InvestmentInRelatedPartyTextBlock"/>
  <xs:element name="DescriptionOfAccountingPolicyForBasisOfPreparationTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_DescriptionOfAccountingPolicyForBasisOfPreparationTextBlock"/>
  <xs:element name="DescriptionOfAccountingPolicyForGoingConcern" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_DescriptionOfAccountingPolicyForGoingConcern"/>
  <xs:element name="DescriptionOfAccountingPolicyForNewAndRevisedStandardsTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_DescriptionOfAccountingPolicyForNewAndRevisedStandardsTextBlock"/>
  <xs:element name="DescriptionOfAccountingPolicyForBasisofConsolidation" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_DescriptionOfAccountingPolicyForBasisofConsolidation"/>
  <xs:element name="DescriptionOfAccountingPolicyForLicenseFees" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_DescriptionOfAccountingPolicyForLicenseFees"/>
  <xs:element name="DescriptionOfAccountingPolicyForWarrantsTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_DescriptionOfAccountingPolicyForWarrantsTextBlock"/>
  <xs:element name="DisclosureOfDetailedInformationAboutOperatingLoss" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_DisclosureOfDetailedInformationAboutOperatingLoss"/>
  <xs:element name="OperatingLossTablesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tlsa_OperatingLossTablesTable"/>
  <xs:element name="OperatingLossTablesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_OperatingLossTablesLineItems"/>
  <xs:element name="DisclosureOfDetailedInformationAboutEmployeesExplanatory" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_DisclosureOfDetailedInformationAboutEmployeesExplanatory"/>
  <xs:element name="DisclosureOfShareOptionsWereGrantedToDirectorTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_DisclosureOfShareOptionsWereGrantedToDirectorTextBlock"/>
  <xs:element name="DisclosureDetailedInformationAboutOfFinanceCostTableTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_DisclosureDetailedInformationAboutOfFinanceCostTableTextBlock"/>
  <xs:element name="DisclosureOfDetailedInformationAboutIncomeTaxExpenseBenefitTableTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_DisclosureOfDetailedInformationAboutIncomeTaxExpenseBenefitTableTextBlock"/>
  <xs:element name="DisclosureOfDetailedInformationAboutOfEarningsPerShareTableTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_DisclosureOfDetailedInformationAboutOfEarningsPerShareTableTextBlock"/>
  <xs:element name="LossPerShareTablesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tlsa_LossPerShareTablesTable"/>
  <xs:element name="LossPerShareTablesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_LossPerShareTablesLineItems"/>
  <xs:element name="DisclosureOfDetailedInformationAboutOtherReceivablesTableTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_DisclosureOfDetailedInformationAboutOtherReceivablesTableTextBlock"/>
  <xs:element name="DisclosureShareCapitalArisingForShareExchangetextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_DisclosureShareCapitalArisingForShareExchangetextBlock"/>
  <xs:element name="ScheduleOfOutstandingFairValueChargeOfTheShareOptionInstrumentsTableTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfOutstandingFairValueChargeOfTheShareOptionInstrumentsTableTextBlock"/>
  <xs:element name="ScheduleOfModelInputsForOptionsGrantedUnderTheBlackScholesValuationModelTableTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfModelInputsForOptionsGrantedUnderTheBlackScholesValuationModelTableTextBlock"/>
  <xs:element name="DisclosureOfRestrictedStockUnitExplanatory" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_DisclosureOfRestrictedStockUnitExplanatory"/>
  <xs:element name="ScheduleOfEstimatedTheFairValueOfWarrantsUsingTableTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfEstimatedTheFairValueOfWarrantsUsingTableTextBlock"/>
  <xs:element name="ScheduleOfFinancialLiabilitiesBasedOnContractualUndiscountedPaymentsTableTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfFinancialLiabilitiesBasedOnContractualUndiscountedPaymentsTableTextBlock"/>
  <xs:element name="ScheduleOfMeasurementOfTheFinancialInstrumentsTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfMeasurementOfTheFinancialInstrumentsTextBlock"/>
  <xs:element name="ScheduleOfTradeAndOtherPayablesTableTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfTradeAndOtherPayablesTableTextBlock"/>
  <xs:element name="TradeandOtherPayablesTablesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tlsa_TradeandOtherPayablesTablesTable"/>
  <xs:element name="TradeandOtherPayablesTablesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_TradeandOtherPayablesTablesLineItems"/>
  <xs:element name="DisclosureOfQuantitativeInformationAboutRightofuseAssetsTableTextBlock" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_DisclosureOfQuantitativeInformationAboutRightofuseAssetsTableTextBlock"/>
  <xs:element name="DisclosureOfFutureMinimumLeasePayments" type="dtr:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_DisclosureOfFutureMinimumLeasePayments"/>
  <xs:element name="AccountingPoliciesScheduleofEstimatedUsefulLivesfortheCurrentPeriodandtheComparativePeriodDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tlsa_AccountingPoliciesScheduleofEstimatedUsefulLivesfortheCurrentPeriodandtheComparativePeriodDetailsTable"/>
  <xs:element name="EstimatedUsefulLives" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_EstimatedUsefulLives"/>
  <xs:element name="RightOfUseAssetDescription" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_RightOfUseAssetDescription"/>
  <xs:element name="OperatingLossScheduleofOperatingLossesDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tlsa_OperatingLossScheduleofOperatingLossesDetailsTable"/>
  <xs:element name="OperatingLossScheduleofOperatingLossesDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_OperatingLossScheduleofOperatingLossesDetailsLineItems"/>
  <xs:element name="Licensefee" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_Licensefee"/>
  <xs:element name="ForeignExchangegainlosses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ForeignExchangegainlosses"/>
  <xs:element name="RecruitmentFees" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_RecruitmentFees"/>
  <xs:element name="ResearchAndDevelopment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ResearchAndDevelopment"/>
  <xs:element name="CorporateAndAdministration" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_CorporateAndAdministration"/>
  <xs:element name="AverageMonthlyNumberOfEmployeesIncludingDirectorsEmployedByGroup" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_AverageMonthlyNumberOfEmployeesIncludingDirectorsEmployedByGroup"/>
  <xs:element name="RemunerationofKeyManagementPersonnelScheduleofShareOptionsandRestrictedStockAwardsWereGrantedDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tlsa_RemunerationofKeyManagementPersonnelScheduleofShareOptionsandRestrictedStockAwardsWereGrantedDetailsTable"/>
  <xs:element name="NumberOfShareOptionsWereGrantedToDirectors" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_NumberOfShareOptionsWereGrantedToDirectors"/>
  <xs:element name="GainOnSaleOfInvestment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_GainOnSaleOfInvestment"/>
  <xs:element name="FVGainOnInvestment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_FVGainOnInvestment"/>
  <xs:element name="LoanInterestReceived" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_LoanInterestReceived"/>
  <xs:element name="FairValueLossOnInvestment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_FairValueLossOnInvestment"/>
  <xs:element name="NetFinanceExpenseRecognizedInStatementOfComprehensiveIncome" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_NetFinanceExpenseRecognizedInStatementOfComprehensiveIncome"/>
  <xs:element name="AdjustmentsDueToPriorPeriods" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_AdjustmentsDueToPriorPeriods"/>
  <xs:element name="IncomeTaxExpenseContinuingOperation" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_IncomeTaxExpenseContinuingOperation"/>
  <xs:element name="OtherLossBeforeTaxation" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_OtherLossBeforeTaxation"/>
  <xs:element name="IncomeTaxReconciliationLossChargedAtStandardRateOfCorporationTax" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_IncomeTaxReconciliationLossChargedAtStandardRateOfCorporationTax"/>
  <xs:element name="MovementInUnrecognisedDeferredTax" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_MovementInUnrecognisedDeferredTax"/>
  <xs:element name="IncomeTaxReconciliationExpensesNotDeductibleForTaxation" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_IncomeTaxReconciliationExpensesNotDeductibleForTaxation"/>
  <xs:element name="AdjustmentsDueToPriorPeriod" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_AdjustmentsDueToPriorPeriod"/>
  <xs:element name="IncomeTaxReconciliationResearchAndDevelopmentClaim" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_IncomeTaxReconciliationResearchAndDevelopmentClaim"/>
  <xs:element name="IncomeNotTaxableForTaxPurposes" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_IncomeNotTaxableForTaxPurposes"/>
  <xs:element name="FixedAssetDifferences" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_FixedAssetDifferences"/>
  <xs:element name="CapitalGainslosses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_CapitalGainslosses"/>
  <xs:element name="CurrentTaxOther" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_CurrentTaxOther"/>
  <xs:element name="ForeignTaxOther" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ForeignTaxOther"/>
  <xs:element name="BasicLossPerSharecentsPerShare" type="dtr:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_BasicLossPerSharecentsPerShare"/>
  <xs:element name="SecurityDepositsReceivable" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_SecurityDepositsReceivable"/>
  <xs:element name="NominalValueAnnualReport" type="dtr:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="tlsa_NominalValueAnnualReport"/>
  <xs:element name="ShareCapitalSharesBeginning" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareCapitalSharesBeginning"/>
  <xs:element name="ShareCapitalValueAtBeginning" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareCapitalValueAtBeginning"/>
  <xs:element name="SharePremiumAtBeginning" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_SharePremiumAtBeginning"/>
  <xs:element name="MergerReserveAtBeginning" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_MergerReserveAtBeginning"/>
  <xs:element name="NominalValueSharesIssuedInLieuOfFees" type="dtr:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_NominalValueSharesIssuedInLieuOfFees"/>
  <xs:element name="ShareCapitalSharesIssuedInLieuOfFees" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareCapitalSharesIssuedInLieuOfFees"/>
  <xs:element name="ShareCapitalValueSharesIssuedInLieuOfFees" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareCapitalValueSharesIssuedInLieuOfFees"/>
  <xs:element name="SharePremiumSharesIssuedInLieuOfFees" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_SharePremiumSharesIssuedInLieuOfFees"/>
  <xs:element name="MergerReserveSharesIssuedInLieuOfFeescompensation" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_MergerReserveSharesIssuedInLieuOfFeescompensation"/>
  <xs:element name="NominalValueOptionsExercised" type="dtr:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_NominalValueOptionsExercised"/>
  <xs:element name="ShareCapitalSharesOptionsExercised" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareCapitalSharesOptionsExercised"/>
  <xs:element name="ShareCapitalValueOptionsExercised" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareCapitalValueOptionsExercised"/>
  <xs:element name="SharePremiumOptionsExercised" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_SharePremiumOptionsExercised"/>
  <xs:element name="MergerReserveOptionsExercised" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_MergerReserveOptionsExercised"/>
  <xs:element name="NominalValueIssuanceOfStockFundraising" type="dtr:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_NominalValueIssuanceOfStockFundraising"/>
  <xs:element name="ShareCapitalSharesIssuanceOfStockFundraising" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareCapitalSharesIssuanceOfStockFundraising"/>
  <xs:element name="ShareCapitalValueIssuanceOfStockFundraising" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareCapitalValueIssuanceOfStockFundraising"/>
  <xs:element name="SharePremiumIssuanceOfStockFundraising" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_SharePremiumIssuanceOfStockFundraising"/>
  <xs:element name="MergerReserveIssuanceOfStockFundraising" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_MergerReserveIssuanceOfStockFundraising"/>
  <xs:element name="NominalValueIssuanceOfWarrantsFundraising" type="dtr:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_NominalValueIssuanceOfWarrantsFundraising"/>
  <xs:element name="ShareCapitalSharesIssuanceOfWarrantsFundraising" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareCapitalSharesIssuanceOfWarrantsFundraising"/>
  <xs:element name="ShareCapitalValueCapitalValueIssuanceOfWarrantsFundraising" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareCapitalValueCapitalValueIssuanceOfWarrantsFundraising"/>
  <xs:element name="SharePremiumIssuanceOfWarrantsFundraising" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_SharePremiumIssuanceOfWarrantsFundraising"/>
  <xs:element name="NominalValueCancellationOfTreasuryShares" type="dtr:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_NominalValueCancellationOfTreasuryShares"/>
  <xs:element name="ShareCapitalSharesCancellationOfTreasuryShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareCapitalSharesCancellationOfTreasuryShares"/>
  <xs:element name="ShareCapitalValueCancellationOfTreasuryShares" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareCapitalValueCancellationOfTreasuryShares"/>
  <xs:element name="SharePremiumCancellationOfTreasuryShares" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_SharePremiumCancellationOfTreasuryShares"/>
  <xs:element name="MergerReserveCancellationOfTreasuryShares" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_MergerReserveCancellationOfTreasuryShares"/>
  <xs:element name="NominalValueWarrantsExercised" type="dtr:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_NominalValueWarrantsExercised"/>
  <xs:element name="ShareCapitalSharesWarrantsExercised" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareCapitalSharesWarrantsExercised"/>
  <xs:element name="ShareCapitalValueWarrantsExercised" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareCapitalValueWarrantsExercised"/>
  <xs:element name="SharePremiumWarrantsExercised" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_SharePremiumWarrantsExercised"/>
  <xs:element name="MergerReserveWarrantsExercised" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_MergerReserveWarrantsExercised"/>
  <xs:element name="NominalValueIssuanceOfStockATM" type="dtr:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_NominalValueIssuanceOfStockATM"/>
  <xs:element name="ShareCapitalSharesIssuanceOfStockATM" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareCapitalSharesIssuanceOfStockATM"/>
  <xs:element name="ShareCapitalValueIssuanceOfStockATM" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareCapitalValueIssuanceOfStockATM"/>
  <xs:element name="SharePremiumIssuanceOfStockATM" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_SharePremiumIssuanceOfStockATM"/>
  <xs:element name="MergerReserveIssuanceOfStockATM" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_MergerReserveIssuanceOfStockATM"/>
  <xs:element name="ShareCapitalSharesEndinginShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareCapitalSharesEndinginShares"/>
  <xs:element name="ShareCapitalValueEnding" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareCapitalValueEnding"/>
  <xs:element name="SharePremiumEnding" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_SharePremiumEnding"/>
  <xs:element name="MergerReserveEnding" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_MergerReserveEnding"/>
  <xs:element name="StockPlanNameDomainDomain" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_StockPlanNameDomainDomain"/>
  <xs:element name="ShareBasedPaymentsScheduleofShareOptionPlanDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tlsa_ShareBasedPaymentsScheduleofShareOptionPlanDetailsTable"/>
  <xs:element name="ShareBasedPaymentsScheduleofShareOptionPlanDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareBasedPaymentsScheduleofShareOptionPlanDetailsLineItems"/>
  <xs:element name="ShareBasedPaymentsScheduleofShareOptionsExpiryDatesandExercisePriceDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tlsa_ShareBasedPaymentsScheduleofShareOptionsExpiryDatesandExercisePriceDetailsTable"/>
  <xs:element name="ShareBasedPaymentsScheduleofShareOptionsExpiryDatesandExercisePriceDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareBasedPaymentsScheduleofShareOptionsExpiryDatesandExercisePriceDetailsLineItems"/>
  <xs:element name="ShareOptionsOutstandingExpiryDate" type="xbrli:dateItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareOptionsOutstandingExpiryDate"/>
  <xs:element name="NumberOfOutstandingRestrictedStockOptions" type="xbrli:decimalItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="tlsa_NumberOfOutstandingRestrictedStockOptions"/>
  <xs:element name="ShareBasedPaymentsScheduleofShareBasedPaymentTransactionsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tlsa_ShareBasedPaymentsScheduleofShareBasedPaymentTransactionsDetailsTable"/>
  <xs:element name="ShareBasedPaymentsScheduleofShareBasedPaymentTransactionsDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareBasedPaymentsScheduleofShareBasedPaymentTransactionsDetailsLineItems"/>
  <xs:element name="ShareOptionsGrantDateSharePrice" type="dtr:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareOptionsGrantDateSharePrice"/>
  <xs:element name="WeightedAverageFairValuePerShareOption" type="dtr:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_WeightedAverageFairValuePerShareOption"/>
  <xs:element name="ShareBasedPaymentsScheduleofRestrictedStockUnitDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tlsa_ShareBasedPaymentsScheduleofRestrictedStockUnitDetailsTable"/>
  <xs:element name="ShareBasedPaymentsScheduleofRestrictedStockUnitDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareBasedPaymentsScheduleofRestrictedStockUnitDetailsLineItems"/>
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGrantDateFairValueOutstandingNumber" type="dtr:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGrantDateFairValueOutstandingNumber"/>
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGrantDateFairValueofGrantDatePriceGranted" type="dtr:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsGrantDateFairValueofGrantDatePriceGranted"/>
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisableWeightedAverageGrantDateFairValue" type="dtr:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercisableWeightedAverageGrantDateFairValue"/>
  <xs:element name="ShareBasedPaymentsScheduleofEstimatedtheFairValueofWarrantsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tlsa_ShareBasedPaymentsScheduleofEstimatedtheFairValueofWarrantsDetailsTable"/>
  <xs:element name="ShareBasedPaymentsScheduleofEstimatedtheFairValueofWarrantsDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareBasedPaymentsScheduleofEstimatedtheFairValueofWarrantsDetailsLineItems"/>
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOfOtherEquityInstrumentsOutstandingBalanceInSharebasedPaymentArrangement" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareBasedCompensationArrangementByShareBasedPaymentAwardOfOtherEquityInstrumentsOutstandingBalanceInSharebasedPaymentArrangement"/>
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsIssued" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsIssued"/>
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercised" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExercised"/>
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpiredInPeriod" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsExpiredInPeriod"/>
  <xs:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOfOtherEquityInstrumentsOutstandingEndingBalanceInSharebasedPaymentArrangement" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareBasedCompensationArrangementByShareBasedPaymentAwardOfOtherEquityInstrumentsOutstandingEndingBalanceInSharebasedPaymentArrangement"/>
  <xs:element name="FinancialInstrumentsScheduleofFinancialLiabilitiesBasedonContractualUndiscountedPaymentsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tlsa_FinancialInstrumentsScheduleofFinancialLiabilitiesBasedonContractualUndiscountedPaymentsDetailsTable"/>
  <xs:element name="RelatedPartyPayablesAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_RelatedPartyPayablesAmount"/>
  <xs:element name="FinancialInstrumentsNet" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_FinancialInstrumentsNet"/>
  <xs:element name="FinancialInstrumentsScheduleofAllOtherVariablesRemainConstantDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tlsa_FinancialInstrumentsScheduleofAllOtherVariablesRemainConstantDetailsTable"/>
  <xs:element name="ProfitOrLossAndEquityStrengthening" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ProfitOrLossAndEquityStrengthening"/>
  <xs:element name="ProfitOrLossAndEquityWeakening" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ProfitOrLossAndEquityWeakening"/>
  <xs:element name="FinancialInstrumentsScheduleofAllOtherVariablesRemainConstantParentheticalsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tlsa_FinancialInstrumentsScheduleofAllOtherVariablesRemainConstantParentheticalsDetailsTable"/>
  <xs:element name="MovementPercentageStrengthening" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_MovementPercentageStrengthening"/>
  <xs:element name="MovementPercentageWeakening" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_MovementPercentageWeakening"/>
  <xs:element name="InvestmentinRelatedPartyScheduleofInvestmentinRelatedPartyDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tlsa_InvestmentinRelatedPartyScheduleofInvestmentinRelatedPartyDetailsTable"/>
  <xs:element name="ImpairmentLossOnFinancialAsset" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ImpairmentLossOnFinancialAsset"/>
  <xs:element name="AdditionalSharesIssued" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_AdditionalSharesIssued"/>
  <xs:element name="AdditionalSharesSold" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_AdditionalSharesSold"/>
  <xs:element name="RightOfUseAssetBeginning" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_RightOfUseAssetBeginning"/>
  <xs:element name="RightOfUseAssetsBostonOfficeLease" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_RightOfUseAssetsBostonOfficeLease"/>
  <xs:element name="RightOfUseAssetsRentFreePeriodAdjustment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_RightOfUseAssetsRentFreePeriodAdjustment"/>
  <xs:element name="RightOfUseAssetsDepreciation" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_RightOfUseAssetsDepreciation"/>
  <xs:element name="RightOfUseAssetsExchangeDifferences" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_RightOfUseAssetsExchangeDifferences"/>
  <xs:element name="RightOfUseAssetsTotal" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_RightOfUseAssetsTotal"/>
  <xs:element name="LeaseLiabilitiesBeginning" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_LeaseLiabilitiesBeginning"/>
  <xs:element name="LeaseLiabilitiesBostonOfficeLease" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_LeaseLiabilitiesBostonOfficeLease"/>
  <xs:element name="LeaseLiabilitiesRentFreePeriodAdjustment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_LeaseLiabilitiesRentFreePeriodAdjustment"/>
  <xs:element name="LeaseLiabilitiesInterestExpense" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_LeaseLiabilitiesInterestExpense"/>
  <xs:element name="LeaseLiabilitiesPrepaidLeasePayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_LeaseLiabilitiesPrepaidLeasePayment"/>
  <xs:element name="LeaseLiabilitiesLeasePayments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_LeaseLiabilitiesLeasePayments"/>
  <xs:element name="LeaseLiabilitiesExchangeDifferences" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_LeaseLiabilitiesExchangeDifferences"/>
  <xs:element name="LeaseLiabilitiesTotal" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_LeaseLiabilitiesTotal"/>
  <xs:element name="LeasesScheduleofFutureMinimumLeasePaymentsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tlsa_LeasesScheduleofFutureMinimumLeasePaymentsDetailsTable"/>
  <xs:element name="LeasePayments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_LeasePayments"/>
  <xs:element name="FinanceCharges" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_FinanceCharges"/>
  <xs:element name="NetPresentValues" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_NetPresentValues"/>
  <xs:element name="AccumulatedLoss" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_AccumulatedLoss"/>
  <xs:element name="CashSurplus" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_CashSurplus"/>
  <xs:element name="NumberOfSegment" type="xbrli:integerItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_NumberOfSegment"/>
  <xs:element name="RemunerationofKeyManagementPersonnelDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tlsa_RemunerationofKeyManagementPersonnelDetailsTable"/>
  <xs:element name="PostEmploymentSeverancePayments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_PostEmploymentSeverancePayments"/>
  <xs:element name="MaximumPercentageOfSurrenderableLosses" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_MaximumPercentageOfSurrenderableLosses"/>
  <xs:element name="TermOfResearchAndDevelopmentTaxReliefClaims" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_TermOfResearchAndDevelopmentTaxReliefClaims"/>
  <xs:element name="ShareCapitalandSharePremiumDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tlsa_ShareCapitalandSharePremiumDetailsTable"/>
  <xs:element name="ShareCapitalandSharePremiumDetailsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareCapitalandSharePremiumDetailsLineItems"/>
  <xs:element name="TreasuryShares1" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_TreasuryShares1"/>
  <xs:element name="NumberOfSharesIssued1" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_NumberOfSharesIssued1"/>
  <xs:element name="ShareBasedPaymentsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tlsa_ShareBasedPaymentsDetailsTable"/>
  <xs:element name="OutstandingFairValueCharges" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_OutstandingFairValueCharges"/>
  <xs:element name="ShareOptionPlanForfeiture" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareOptionPlanForfeiture"/>
  <xs:element name="StockOptionsExercisedInPeriod" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_StockOptionsExercisedInPeriod"/>
  <xs:element name="OutstandingFairValueChargeOfTheRestrictedStockInstruments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_OutstandingFairValueChargeOfTheRestrictedStockInstruments"/>
  <xs:element name="InvestmentinRelatedPartyDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tlsa_InvestmentinRelatedPartyDetailsTable"/>
  <xs:element name="AcquiredAdditionalIssuedShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_AcquiredAdditionalIssuedShares"/>
  <xs:element name="AcquiredPricePerShare" type="dtr1:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_AcquiredPricePerShare"/>
  <xs:element name="AcquiredShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_AcquiredShares"/>
  <xs:element name="AcquiredSharesSold" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="tlsa_AcquiredSharesSold"/>
  <xs:element name="AcquiredSharesOwnershipPercentage" type="dtr:percentItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="tlsa_AcquiredSharesOwnershipPercentage"/>
  <xs:element name="SharesPrice" type="dtr:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="tlsa_SharesPrice"/>
  <xs:element name="ClassOfWarrantsOrRightDomainDomain" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ClassOfWarrantsOrRightDomainDomain"/>
  <xs:element name="TreasurySharesDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tlsa_TreasurySharesDetailsTable"/>
  <xs:element name="RelatedPartyTransactionsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tlsa_RelatedPartyTransactionsDetailsTable"/>
  <xs:element name="InterestAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_InterestAmount"/>
  <xs:element name="ShortTermLoanFacility1" type="dtr:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShortTermLoanFacility1"/>
  <xs:element name="PayrollAndRentCharged" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_PayrollAndRentCharged"/>
  <xs:element name="ServicesAgreementAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ServicesAgreementAmount"/>
  <xs:element name="InitialAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_InitialAmount"/>
  <xs:element name="AdditionalPayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_AdditionalPayment"/>
  <xs:element name="MilestonePaymentDue" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_MilestonePaymentDue"/>
  <xs:element name="PrincipalAmount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_PrincipalAmount"/>
  <xs:element name="FinancialCommitmentsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tlsa_FinancialCommitmentsDetailsTable"/>
  <xs:element name="AccruedOfDiligenceObligations" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_AccruedOfDiligenceObligations"/>
  <xs:element name="DevelopmentMilestones" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_DevelopmentMilestones"/>
  <xs:element name="MilestonePayments" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_MilestonePayments"/>
  <xs:element name="CommercialSaleOfAProduct" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_CommercialSaleOfAProduct"/>
  <xs:element name="SubsequentEventsDetailsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="tlsa_SubsequentEventsDetailsTable"/>
  <xs:element name="EstimatedOfferingExpenses" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_EstimatedOfferingExpenses"/>
  <xs:element name="NetProceeds" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" xbrli:balance="debit" nillable="true" substitutionGroup="xbrli:item" id="tlsa_NetProceeds"/>
  <xs:element name="PurchaseOfOrdinaryShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="tlsa_PurchaseOfOrdinaryShares"/>
  <xs:element name="WarrantReceived" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="tlsa_WarrantReceived"/>
  <xs:element name="ClassOfWarrantsOrRightAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="tlsa_ClassOfWarrantsOrRightAxis"/>
  <xs:element name="StockPlanNameAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="tlsa_StockPlanNameAxis"/>
  <xs:element name="AccustemSciencesIncMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_AccustemSciencesIncMember"/>
  <xs:element name="BLAMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_BLAMember"/>
  <xs:element name="DirectorsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_DirectorsMember"/>
  <xs:element name="EventsAfterReportingPeriodMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_EventsAfterReportingPeriodMember"/>
  <xs:element name="FourteenAugustTwoTousandTwentyFourMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_FourteenAugustTwoTousandTwentyFourMember"/>
  <xs:element name="FourteenMarchTwoThousandTwenttyThreeMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_FourteenMarchTwoThousandTwenttyThreeMember"/>
  <xs:element name="InvestmentInAccustemSciencesIncMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_InvestmentInAccustemSciencesIncMember"/>
  <xs:element name="LaterThanTwoYearsAndNotLaterThanFiveYearMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_LaterThanTwoYearsAndNotLaterThanFiveYearMember"/>
  <xs:element name="LessThanThreeMonthMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_LessThanThreeMonthMember"/>
  <xs:element name="NASDAQStockExchangeMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_NASDAQStockExchangeMember"/>
  <xs:element name="OKYOPharmaLtdMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_OKYOPharmaLtdMember"/>
  <xs:element name="OtherKeyManagementPersonnelMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_OtherKeyManagementPersonnelMember"/>
  <xs:element name="PanettaPartnersLtdMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_PanettaPartnersLtdMember"/>
  <xs:element name="PhaseIHumanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_PhaseIHumanMember"/>
  <xs:element name="PhaseIIHumanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_PhaseIIHumanMember"/>
  <xs:element name="PhaseIIIClinicalTrialMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_PhaseIIIClinicalTrialMember"/>
  <xs:element name="PhaseIIIHumanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_PhaseIIIHumanMember"/>
  <xs:element name="RSUReserveMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_RSUReserveMember"/>
  <xs:element name="RasnaTherapeuticsIncMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_RasnaTherapeuticsIncMember"/>
  <xs:element name="RightOfUseAssetMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_RightOfUseAssetMember"/>
  <xs:element name="SecuritiesPurchaseAgreementsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_SecuritiesPurchaseAgreementsMember"/>
  <xs:element name="ShareBasedPaymentReserveWarrantsMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ShareBasedPaymentReserveWarrantsMember"/>
  <xs:element name="SharesToBeIssuedReserveMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_SharesToBeIssuedReserveMember"/>
  <xs:element name="SixMayTwoThousandTwentyMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_SixMayTwoThousandTwentyMember"/>
  <xs:element name="ThirteenMarchTwoThousandTwentyFourMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ThirteenMarchTwoThousandTwentyFourMember"/>
  <xs:element name="ThirtyAprilTwoThousandEighteenMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ThirtyAprilTwoThousandEighteenMember"/>
  <xs:element name="ThreeMayTwoThousandTwentyFourMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ThreeMayTwoThousandTwentyFourMember"/>
  <xs:element name="ThreeOctoberTwoThousandTwentyFourMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ThreeOctoberTwoThousandTwentyFourMember"/>
  <xs:element name="ThreeToTwelveMonthMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ThreeToTwelveMonthMember"/>
  <xs:element name="TizianaLifeSciencesLtdShareOptionPlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_TizianaLifeSciencesLtdShareOptionPlanMember"/>
  <xs:element name="TizianaLifeSciencesPLCShareOptionPlanMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_TizianaLifeSciencesPLCShareOptionPlanMember"/>
  <xs:element name="TranslationReserveMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_TranslationReserveMember"/>
  <xs:element name="TwentyEightMarchTwoThousandTwentyFiveMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_TwentyEightMarchTwoThousandTwentyFiveMember"/>
  <xs:element name="TwentyFiveAugustTwoThousandTwentyMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_TwentyFiveAugustTwoThousandTwentyMember"/>
  <xs:element name="TwentyThreeJulyTwoThousandTwentyMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_TwentyThreeJulyTwoThousandTwentyMember"/>
  <xs:element name="USDMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_USDMember"/>
  <xs:element name="ZeroEightAugustTwoThousandTwentyFourMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ZeroEightAugustTwoThousandTwentyFourMember"/>
  <xs:element name="ZeroFiveSeptemberTwoThousandTwentyFiveMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ZeroFiveSeptemberTwoThousandTwentyFiveMember"/>
  <xs:element name="ZeroFourNovemberTwoThousandTwentyTwoMember" type="dtr:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ZeroFourNovemberTwoThousandTwentyTwoMember"/>
  <xs:element name="EmployeesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_EmployeesAbstract"/>
  <xs:element name="FinanceOtherIncomeRevenueAndCostsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_FinanceOtherIncomeRevenueAndCostsAbstract"/>
  <xs:element name="FinancialCommitmentsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_FinancialCommitmentsAbstract"/>
  <xs:element name="FinancialCommitmentsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_FinancialCommitmentsLineItems"/>
  <xs:element name="InvestmentInRelatedPartyAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_InvestmentInRelatedPartyAbstract"/>
  <xs:element name="InvestmentInRelatedPartyLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_InvestmentInRelatedPartyLineItems"/>
  <xs:element name="OperatingExpenseAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_OperatingExpenseAbstract"/>
  <xs:element name="OperatingLossAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_OperatingLossAbstract"/>
  <xs:element name="OtherIncomeExpenseAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_OtherIncomeExpenseAbstract"/>
  <xs:element name="RelatedPartyTransactionsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_RelatedPartyTransactionsLineItems"/>
  <xs:element name="RemunerationOfKeyManagementPersonnelAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_RemunerationOfKeyManagementPersonnelAbstract"/>
  <xs:element name="RemunerationOfKeyManagementsPersonnelLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_RemunerationOfKeyManagementsPersonnelLineItems"/>
  <xs:element name="ScheduleOfAllOtherVariablesRemainConstantLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfAllOtherVariablesRemainConstantLineItems"/>
  <xs:element name="ScheduleOfDeferredIncomeAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfDeferredIncomeAbstract"/>
  <xs:element name="ScheduleOfFinancialLiabilitiesBasedOnContractualUndiscountedPaymentsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfFinancialLiabilitiesBasedOnContractualUndiscountedPaymentsLineItems"/>
  <xs:element name="ScheduleOfFutureMinimumLeasePaymentsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfFutureMinimumLeasePaymentsLineItems"/>
  <xs:element name="ScheduleOfInvestmentInRelatedPartyLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfInvestmentInRelatedPartyLineItems"/>
  <xs:element name="ScheduleOfRightofUseAssetsAndLeaseLiabilitiesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfRightofUseAssetsAndLeaseLiabilitiesAbstract"/>
  <xs:element name="ScheduleOfShareCapitalArisingOnTheShareForShareExchangeAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfShareCapitalArisingOnTheShareForShareExchangeAbstract"/>
  <xs:element name="ScheduleOfShareOptionsWereGrantedToDirectorsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_ScheduleOfShareOptionsWereGrantedToDirectorsLineItems"/>
  <xs:element name="TaxationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_TaxationAbstract"/>
  <xs:element name="TreasurySharesAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_TreasurySharesAbstract"/>
  <xs:element name="TreasurySharesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_TreasurySharesLineItems"/>
<!-- [WMV7][Ih2k1Th/DDUB0NBBhgHHBCnfSlucWVDJzZZgPsjlqj83rUbni7qiXxiZn8Tn+jiBAsLeKDPxlc5o0OHmdEVuxpv8/M5v68YtcsUiCjN+TjWPbxIIir41wW1sRqHweHENStAO3/TBKKNc8sayxK+P2lg0Aj5wxRRl322I9kR2jwTn5dXGTuupcIEgTqtfQLLGJ36yc403nZTk3OKKuqCU3bzO4pr8RtJi/wJQGMmBp6HgW+LdQ3YLEcm20GDdxBIglLj8CAjTGXkoeTAc0B1l1bzS/aU0f/7Ovxarsh1+Z2sjogOgUJsnhaTqgmlfGRPR5+ydXYQyQEbxZUyzaC57DKa4RVmP1BVJbLUS0G0BE/mPTjH6huY=] CSR-->
  <xs:element name="DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="tlsa_DocumentAndEntityInformationAbstract"/>
</xs:schema>
