<?xml version="1.0" encoding="US-ASCII"?>
<!-- Generated by CompSci Transform (tm) - http://www.compsciresources.com -->
<!-- Created: Wed Apr 26 18:04:09 UTC 2023 -->
<linkbase xmlns="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ConsolidatedBalanceSheet" roleURI="http://tizianalifesciences.com/role/ConsolidatedBalanceSheet"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ConsolidatedBalanceSheet_Parentheticals" roleURI="http://tizianalifesciences.com/role/ConsolidatedBalanceSheet_Parentheticals"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ConsolidatedIncomeStatement" roleURI="http://tizianalifesciences.com/role/ConsolidatedIncomeStatement"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ConsolidatedIncomeStatement_Parentheticals" roleURI="http://tizianalifesciences.com/role/ConsolidatedIncomeStatement_Parentheticals"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ShareholdersEquityType2or3" roleURI="http://tizianalifesciences.com/role/ShareholdersEquityType2or3"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ConsolidatedCashFlow" roleURI="http://tizianalifesciences.com/role/ConsolidatedCashFlow"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_GeneralInformation" roleURI="http://tizianalifesciences.com/role/GeneralInformation"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_AccountingPolicies" roleURI="http://tizianalifesciences.com/role/AccountingPolicies"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_CriticalAccountingJudgement" roleURI="http://tizianalifesciences.com/role/CriticalAccountingJudgement"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_OtherexpenseIncome" roleURI="http://tizianalifesciences.com/role/OtherexpenseIncome"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_OperatingLoss" roleURI="http://tizianalifesciences.com/role/OperatingLoss"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_SegmentalReporting" roleURI="http://tizianalifesciences.com/role/SegmentalReporting"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_Employees" roleURI="http://tizianalifesciences.com/role/Employees"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_RemunerationofKeyManagementPersonnel" roleURI="http://tizianalifesciences.com/role/RemunerationofKeyManagementPersonnel"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_FinanceCosts" roleURI="http://tizianalifesciences.com/role/FinanceCosts"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_Taxation" roleURI="http://tizianalifesciences.com/role/Taxation"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_LossPerShare" roleURI="http://tizianalifesciences.com/role/LossPerShare"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_OtherReceivables" roleURI="http://tizianalifesciences.com/role/OtherReceivables"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ShareCapitalandSharePremium" roleURI="http://tizianalifesciences.com/role/ShareCapitalandSharePremium"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ShareBasedPayments" roleURI="http://tizianalifesciences.com/role/ShareBasedPayments"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_Reserves" roleURI="http://tizianalifesciences.com/role/Reserves"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_FinancialInstruments" roleURI="http://tizianalifesciences.com/role/FinancialInstruments"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_CapitalRiskManagement" roleURI="http://tizianalifesciences.com/role/CapitalRiskManagement"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_TradeandOtherPayables" roleURI="http://tizianalifesciences.com/role/TradeandOtherPayables"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_InvestmentinRelatedParty" roleURI="http://tizianalifesciences.com/role/InvestmentinRelatedParty"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_TreasuryShares" roleURI="http://tizianalifesciences.com/role/TreasuryShares"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_RelatedPartyTransactions" roleURI="http://tizianalifesciences.com/role/RelatedPartyTransactions"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_Leases" roleURI="http://tizianalifesciences.com/role/Leases"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_FinancialCommitments" roleURI="http://tizianalifesciences.com/role/FinancialCommitments"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ContingentLiabilities" roleURI="http://tizianalifesciences.com/role/ContingentLiabilities"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_PostBalanceSheetEvents" roleURI="http://tizianalifesciences.com/role/PostBalanceSheetEvents"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_AccountingPoliciesByPolicy" roleURI="http://tizianalifesciences.com/role/AccountingPoliciesByPolicy"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_AccountingPoliciesTables" roleURI="http://tizianalifesciences.com/role/AccountingPoliciesTables"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_OtherexpenseIncomeTables" roleURI="http://tizianalifesciences.com/role/OtherexpenseIncomeTables"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_OperatingLossTables" roleURI="http://tizianalifesciences.com/role/OperatingLossTables"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_EmployeesTables" roleURI="http://tizianalifesciences.com/role/EmployeesTables"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_RemunerationofKeyManagementPersonnelTables" roleURI="http://tizianalifesciences.com/role/RemunerationofKeyManagementPersonnelTables"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_FinanceCostsTables" roleURI="http://tizianalifesciences.com/role/FinanceCostsTables"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_TaxationTables" roleURI="http://tizianalifesciences.com/role/TaxationTables"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_LossPerShareTables" roleURI="http://tizianalifesciences.com/role/LossPerShareTables"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_OtherReceivablesTables" roleURI="http://tizianalifesciences.com/role/OtherReceivablesTables"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ShareCapitalandSharePremiumTables" roleURI="http://tizianalifesciences.com/role/ShareCapitalandSharePremiumTables"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ShareBasedPaymentsTables" roleURI="http://tizianalifesciences.com/role/ShareBasedPaymentsTables"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_FinancialInstrumentsTables" roleURI="http://tizianalifesciences.com/role/FinancialInstrumentsTables"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_TradeandOtherPayablesTables" roleURI="http://tizianalifesciences.com/role/TradeandOtherPayablesTables"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_InvestmentinRelatedPartyTables" roleURI="http://tizianalifesciences.com/role/InvestmentinRelatedPartyTables"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_LeasesTables" roleURI="http://tizianalifesciences.com/role/LeasesTables"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ScheduleofestimatedusefullivesforthecurrentperiodandthecomparativeperiodTable" roleURI="http://tizianalifesciences.com/role/ScheduleofestimatedusefullivesforthecurrentperiodandthecomparativeperiodTable"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ScheduleofotherexpenseincomeTable" roleURI="http://tizianalifesciences.com/role/ScheduleofotherexpenseincomeTable"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ScheduleofoperatinglossesTable" roleURI="http://tizianalifesciences.com/role/ScheduleofoperatinglossesTable"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ScheduleofemployeesTable" roleURI="http://tizianalifesciences.com/role/ScheduleofemployeesTable"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ScheduleofremunerationofkeymanagementpersonnelTable" roleURI="http://tizianalifesciences.com/role/ScheduleofremunerationofkeymanagementpersonnelTable"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ScheduleofshareoptionsweregrantedtodirectorsTable" roleURI="http://tizianalifesciences.com/role/ScheduleofshareoptionsweregrantedtodirectorsTable"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ScheduleoffinancecostsTable" roleURI="http://tizianalifesciences.com/role/ScheduleoffinancecostsTable"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ScheduleoftaxationTable" roleURI="http://tizianalifesciences.com/role/ScheduleoftaxationTable"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ScheduleoftaxationTable_Parentheticals" roleURI="http://tizianalifesciences.com/role/ScheduleoftaxationTable_Parentheticals"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ScheduleofbasiclosspershareTable" roleURI="http://tizianalifesciences.com/role/ScheduleofbasiclosspershareTable"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ScheduleofotherreceivablesTable" roleURI="http://tizianalifesciences.com/role/ScheduleofotherreceivablesTable"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ScheduleofsharecapitalarisingontheshareforshareexchangeTable" roleURI="http://tizianalifesciences.com/role/ScheduleofsharecapitalarisingontheshareforshareexchangeTable"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ScheduleofshareoptionplanTable" roleURI="http://tizianalifesciences.com/role/ScheduleofshareoptionplanTable"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ScheduleofshareoptionsexpirydatesandexercisepriceTable" roleURI="http://tizianalifesciences.com/role/ScheduleofshareoptionsexpirydatesandexercisepriceTable"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ScheduleofmodelinputsforoptionsgrantedundertheblackscholesvaluationmodelTable" roleURI="http://tizianalifesciences.com/role/ScheduleofmodelinputsforoptionsgrantedundertheblackscholesvaluationmodelTable"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ScheduleofequityincentiveplanTable" roleURI="http://tizianalifesciences.com/role/ScheduleofequityincentiveplanTable"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ScheduleofestimatedthefairvalueofwarrantsusingTable" roleURI="http://tizianalifesciences.com/role/ScheduleofestimatedthefairvalueofwarrantsusingTable"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ScheduleoffinancialliabilitiesbasedoncontractualundiscountedpaymentsTable" roleURI="http://tizianalifesciences.com/role/ScheduleoffinancialliabilitiesbasedoncontractualundiscountedpaymentsTable"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ScheduleofmeasurementofthefinancialinstrumentsdenominatedinaforeigncurrencyandaffectedequityandprofitandlossbytheamountsTable" roleURI="http://tizianalifesciences.com/role/ScheduleofmeasurementofthefinancialinstrumentsdenominatedinaforeigncurrencyandaffectedequityandprofitandlossbytheamountsTable"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ScheduleofmeasurementofthefinancialinstrumentsdenominatedinaforeigncurrencyandaffectedequityandprofitandlossbytheamountsTable_Parentheticals" roleURI="http://tizianalifesciences.com/role/ScheduleofmeasurementofthefinancialinstrumentsdenominatedinaforeigncurrencyandaffectedequityandprofitandlossbytheamountsTable_Parentheticals"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ScheduleoftradeandotherpayablesTable" roleURI="http://tizianalifesciences.com/role/ScheduleoftradeandotherpayablesTable"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ScheduleofinvestmentinrelatedpartyTable" roleURI="http://tizianalifesciences.com/role/ScheduleofinvestmentinrelatedpartyTable"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ScheduleofrightofuseassetsandleaseliabilitiesTable" roleURI="http://tizianalifesciences.com/role/ScheduleofrightofuseassetsandleaseliabilitiesTable"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ScheduleofconsolidatedstatementoffinancialTable" roleURI="http://tizianalifesciences.com/role/ScheduleofconsolidatedstatementoffinancialTable"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ScheduleoffutureminimumleasepaymentsTable" roleURI="http://tizianalifesciences.com/role/ScheduleoffutureminimumleasepaymentsTable"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_AccountingPoliciesDetails" roleURI="http://tizianalifesciences.com/role/AccountingPoliciesDetails"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_OperatingLossDetails" roleURI="http://tizianalifesciences.com/role/OperatingLossDetails"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_RemunerationofKeyManagementPersonnelDetails" roleURI="http://tizianalifesciences.com/role/RemunerationofKeyManagementPersonnelDetails"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_TaxationDetails" roleURI="http://tizianalifesciences.com/role/TaxationDetails"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ShareCapitalandSharePremiumDetails" roleURI="http://tizianalifesciences.com/role/ShareCapitalandSharePremiumDetails"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_ShareBasedPaymentsDetails" roleURI="http://tizianalifesciences.com/role/ShareBasedPaymentsDetails"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_InvestmentinRelatedPartyDetails" roleURI="http://tizianalifesciences.com/role/InvestmentinRelatedPartyDetails"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_TreasurySharesDetails" roleURI="http://tizianalifesciences.com/role/TreasurySharesDetails"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_RelatedPartyTransactionsDetails" roleURI="http://tizianalifesciences.com/role/RelatedPartyTransactionsDetails"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_LeasesDetails" roleURI="http://tizianalifesciences.com/role/LeasesDetails"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_FinancialCommitmentsDetails" roleURI="http://tizianalifesciences.com/role/FinancialCommitmentsDetails"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#tlsa_r_PostBalanceSheetEventsDetails" roleURI="http://tizianalifesciences.com/role/PostBalanceSheetEventsDetails"/>
  <roleRef xlink:type="simple" xlink:href="tlsa-20221231.xsd#DocumentAndEntityInformation" roleURI="http://tizianalifesciences.com/role/DocumentAndEntityInformation"/>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ConsolidatedBalanceSheet">
    <loc xlink:type="locator" xlink:label="ifrs-full_StatementOfFinancialPositionAbstract" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_StatementOfFinancialPositionAbstract"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_CurrentAssetsAbstract" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentAssetsAbstract"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_StatementOfFinancialPositionAbstract" xlink:to="ifrs-full_CurrentAssetsAbstract" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_CashAndCashEquivalents" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashAndCashEquivalents"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CurrentAssetsAbstract" xlink:to="ifrs-full_CashAndCashEquivalents" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="PrepaymentsandOtherReceivablesCurrent" xlink:href="tlsa-20221231.xsd#tlsa_PrepaymentsandOtherReceivablesCurrent"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CurrentAssetsAbstract" xlink:to="PrepaymentsandOtherReceivablesCurrent" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="TaxationReceivable" xlink:href="tlsa-20221231.xsd#tlsa_TaxationReceivable"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CurrentAssetsAbstract" xlink:to="TaxationReceivable" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_AmountsReceivableRelatedPartyTransactions" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AmountsReceivableRelatedPartyTransactions"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CurrentAssetsAbstract" xlink:to="ifrs-full_AmountsReceivableRelatedPartyTransactions" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_CurrentAssets" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentAssets"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CurrentAssetsAbstract" xlink:to="ifrs-full_CurrentAssets" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <loc xlink:type="locator" xlink:label="NonCurrentAssetsAbstract" xlink:href="tlsa-20221231.xsd#tlsa_NonCurrentAssetsAbstract"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_StatementOfFinancialPositionAbstract" xlink:to="NonCurrentAssetsAbstract" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_PropertyPlantAndEquipment" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PropertyPlantAndEquipment"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="NonCurrentAssetsAbstract" xlink:to="ifrs-full_PropertyPlantAndEquipment" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_RightofuseAssets" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_RightofuseAssets"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="NonCurrentAssetsAbstract" xlink:to="ifrs-full_RightofuseAssets" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_IntangibleAssetsOtherThanGoodwill" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IntangibleAssetsOtherThanGoodwill"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="NonCurrentAssetsAbstract" xlink:to="ifrs-full_IntangibleAssetsOtherThanGoodwill" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_TradeAndOtherCurrentReceivablesDueFromRelatedParties" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TradeAndOtherCurrentReceivablesDueFromRelatedParties"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="NonCurrentAssetsAbstract" xlink:to="ifrs-full_TradeAndOtherCurrentReceivablesDueFromRelatedParties" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_NoncurrentAssets" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncurrentAssets"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="NonCurrentAssetsAbstract" xlink:to="ifrs-full_NoncurrentAssets" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_Assets" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Assets"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="NonCurrentAssetsAbstract" xlink:to="ifrs-full_Assets" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_CurrentLiabilitiesAbstract" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentLiabilitiesAbstract"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_StatementOfFinancialPositionAbstract" xlink:to="ifrs-full_CurrentLiabilitiesAbstract" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="AccountsPayableAndAccruedExpensesCurrent" xlink:href="tlsa-20221231.xsd#tlsa_AccountsPayableAndAccruedExpensesCurrent"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CurrentLiabilitiesAbstract" xlink:to="AccountsPayableAndAccruedExpensesCurrent" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_CurrentLeaseLiabilities" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentLeaseLiabilities"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CurrentLiabilitiesAbstract" xlink:to="ifrs-full_CurrentLeaseLiabilities" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_AmountsPayableRelatedPartyTransactions" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AmountsPayableRelatedPartyTransactions"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CurrentLiabilitiesAbstract" xlink:to="ifrs-full_AmountsPayableRelatedPartyTransactions" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_OtherLiabilities" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherLiabilities"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CurrentLiabilitiesAbstract" xlink:to="ifrs-full_OtherLiabilities" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_CurrentLiabilities" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentLiabilities"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CurrentLiabilitiesAbstract" xlink:to="ifrs-full_CurrentLiabilities" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_NoncurrentLeaseLiabilities" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncurrentLeaseLiabilities"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CurrentLiabilitiesAbstract" xlink:to="ifrs-full_NoncurrentLeaseLiabilities" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_Liabilities" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Liabilities"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CurrentLiabilitiesAbstract" xlink:to="ifrs-full_Liabilities" order="6.0" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <loc xlink:type="locator" xlink:label="us-gaap_StockholdersEquityAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityAbstract"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_StatementOfFinancialPositionAbstract" xlink:to="us-gaap_StockholdersEquityAbstract" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_IssuedCapital" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IssuedCapital"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_StockholdersEquityAbstract" xlink:to="ifrs-full_IssuedCapital" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_SharePremium" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SharePremium"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_StockholdersEquityAbstract" xlink:to="ifrs-full_SharePremium" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ReserveOfSharebasedPayments" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ReserveOfSharebasedPayments"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_StockholdersEquityAbstract" xlink:to="ifrs-full_ReserveOfSharebasedPayments" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ShareBasedPaymentReserveWarrants" xlink:href="tlsa-20221231.xsd#tlsa_ShareBasedPaymentReserveWarrants"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_StockholdersEquityAbstract" xlink:to="ShareBasedPaymentReserveWarrants" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_OtherReserves" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherReserves"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_StockholdersEquityAbstract" xlink:to="ifrs-full_OtherReserves" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_TreasuryShares" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TreasuryShares"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_StockholdersEquityAbstract" xlink:to="ifrs-full_TreasuryShares" order="5.0" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ReserveOfExchangeDifferencesOnTranslation" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ReserveOfExchangeDifferencesOnTranslation"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_StockholdersEquityAbstract" xlink:to="ifrs-full_ReserveOfExchangeDifferencesOnTranslation" order="6.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_RetainedEarnings" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_RetainedEarnings"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_StockholdersEquityAbstract" xlink:to="ifrs-full_RetainedEarnings" order="7.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_Equity" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Equity"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_StockholdersEquityAbstract" xlink:to="ifrs-full_Equity" order="8.0" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_EquityAndLiabilities" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_EquityAndLiabilities"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_StockholdersEquityAbstract" xlink:to="ifrs-full_EquityAndLiabilities" order="9.0" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ConsolidatedBalanceSheet_Parentheticals">
    <loc xlink:type="locator" xlink:label="ifrs-full_StatementOfFinancialPositionAbstract" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_StatementOfFinancialPositionAbstract"/>
    <loc xlink:type="locator" xlink:label="IssuanceOfShareCapital" xlink:href="tlsa-20221231.xsd#tlsa_IssuanceOfShareCapital"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_StatementOfFinancialPositionAbstract" xlink:to="IssuanceOfShareCapital" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ShareCapitalOutstanding" xlink:href="tlsa-20221231.xsd#tlsa_ShareCapitalOutstanding"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_StatementOfFinancialPositionAbstract" xlink:to="ShareCapitalOutstanding" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ConsolidatedIncomeStatement">
    <loc xlink:type="locator" xlink:label="ifrs-full_IncomeStatementAbstract" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncomeStatementAbstract"/>
    <loc xlink:type="locator" xlink:label="us-gaap_OperatingExpensesAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingExpensesAbstract"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_IncomeStatementAbstract" xlink:to="us-gaap_OperatingExpensesAbstract" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ResearchAndDevelopmentExpense" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ResearchAndDevelopmentExpense"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_OperatingExpensesAbstract" xlink:to="ifrs-full_ResearchAndDevelopmentExpense" order="0.0" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_OtherOperatingIncomeExpense" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherOperatingIncomeExpense"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_OperatingExpensesAbstract" xlink:to="ifrs-full_OtherOperatingIncomeExpense" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="RealisationBonus" xlink:href="tlsa-20221231.xsd#tlsa_RealisationBonus"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_OperatingExpensesAbstract" xlink:to="RealisationBonus" order="2.0" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ImpairmentLoss" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ImpairmentLoss"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_OperatingExpensesAbstract" xlink:to="ifrs-full_ImpairmentLoss" order="3.0" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_GainsLossesOnDisposalsOfPropertyPlantAndEquipment" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_GainsLossesOnDisposalsOfPropertyPlantAndEquipment"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_OperatingExpensesAbstract" xlink:to="ifrs-full_GainsLossesOnDisposalsOfPropertyPlantAndEquipment" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="TotalOperatingExpenses" xlink:href="tlsa-20221231.xsd#tlsa_TotalOperatingExpenses"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_GainsLossesOnDisposalsOfPropertyPlantAndEquipment" xlink:to="TotalOperatingExpenses" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ProfitLossFromOperatingActivities" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLossFromOperatingActivities"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_IncomeStatementAbstract" xlink:to="ifrs-full_ProfitLossFromOperatingActivities" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <loc xlink:type="locator" xlink:label="OtherIncomeExpenseAbstract" xlink:href="tlsa-20221231.xsd#tlsa_OtherIncomeExpenseAbstract"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_IncomeStatementAbstract" xlink:to="OtherIncomeExpenseAbstract" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_FinanceIncomeCost" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FinanceIncomeCost"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OtherIncomeExpenseAbstract" xlink:to="ifrs-full_FinanceIncomeCost" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="OtherIncomelosses" xlink:href="tlsa-20221231.xsd#tlsa_OtherIncomelosses"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OtherIncomeExpenseAbstract" xlink:to="OtherIncomelosses" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_OtherGainsLosses" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherGainsLosses"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OtherIncomelosses" xlink:to="ifrs-full_OtherGainsLosses" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ProfitLossBeforeTax" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_IncomeStatementAbstract" xlink:to="ifrs-full_ProfitLossBeforeTax" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <loc xlink:type="locator" xlink:label="IncomeTaxSCredit" xlink:href="tlsa-20221231.xsd#tlsa_IncomeTaxSCredit"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_IncomeStatementAbstract" xlink:to="IncomeTaxSCredit" order="4.0" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ProfitLoss" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLoss"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_IncomeStatementAbstract" xlink:to="ifrs-full_ProfitLoss" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_OtherComprehensiveIncomeAbstract" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncomeAbstract"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_IncomeStatementAbstract" xlink:to="ifrs-full_OtherComprehensiveIncomeAbstract" order="6.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_OtherComprehensiveIncomeAbstract" xlink:to="ifrs-full_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ComprehensiveIncome" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ComprehensiveIncome"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_OtherComprehensiveIncomeAbstract" xlink:to="ifrs-full_ComprehensiveIncome" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_BasicEarningsLossPerShare" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_BasicEarningsLossPerShare"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_IncomeStatementAbstract" xlink:to="ifrs-full_BasicEarningsLossPerShare" order="7.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ConsolidatedIncomeStatement_Parentheticals">
    <loc xlink:type="locator" xlink:label="ifrs-full_IncomeStatementAbstract" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncomeStatementAbstract"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DilutedEarningsLossPerShare" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DilutedEarningsLossPerShare"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_IncomeStatementAbstract" xlink:to="ifrs-full_DilutedEarningsLossPerShare" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ShareholdersEquityType2or3">
    <loc xlink:type="locator" xlink:label="ConsolidatedStatementsOfShareholdersEquityAbstract" xlink:href="tlsa-20221231.xsd#tlsa_ConsolidatedStatementsOfShareholdersEquityAbstract"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_StatementOfChangesInEquityTable" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_StatementOfChangesInEquityTable"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_StatementOfChangesInEquityLineItems" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_StatementOfChangesInEquityLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ConsolidatedStatementsOfShareholdersEquityAbstract" xlink:to="ifrs-full_StatementOfChangesInEquityTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ComponentsOfEquityAxis" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ComponentsOfEquityAxis"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_StatementOfChangesInEquityTable" xlink:to="ifrs-full_ComponentsOfEquityAxis" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_IssuedCapitalMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IssuedCapitalMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_ComponentsOfEquityAxis" xlink:to="ifrs-full_IssuedCapitalMember" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_SharePremiumMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SharePremiumMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_ComponentsOfEquityAxis" xlink:to="ifrs-full_SharePremiumMember" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ReserveOfSharebasedPaymentsMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ReserveOfSharebasedPaymentsMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_ComponentsOfEquityAxis" xlink:to="ifrs-full_ReserveOfSharebasedPaymentsMember" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ShareBasedPaymentReserveWarrantsMember" xlink:href="tlsa-20221231.xsd#tlsa_ShareBasedPaymentReserveWarrantsMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_ComponentsOfEquityAxis" xlink:to="ShareBasedPaymentReserveWarrantsMember" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_OtherReservesMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherReservesMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_ComponentsOfEquityAxis" xlink:to="ifrs-full_OtherReservesMember" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_TreasurySharesMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TreasurySharesMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_ComponentsOfEquityAxis" xlink:to="ifrs-full_TreasurySharesMember" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_RetainedEarningsMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_RetainedEarningsMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_ComponentsOfEquityAxis" xlink:to="ifrs-full_RetainedEarningsMember" order="6.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="SharesToBeIssuedReserveMember" xlink:href="tlsa-20221231.xsd#tlsa_SharesToBeIssuedReserveMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_ComponentsOfEquityAxis" xlink:to="SharesToBeIssuedReserveMember" order="7.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="TranslationReserveMember" xlink:href="tlsa-20221231.xsd#tlsa_TranslationReserveMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_ComponentsOfEquityAxis" xlink:to="TranslationReserveMember" order="8.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_EquityMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_EquityMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_ComponentsOfEquityAxis" xlink:to="ifrs-full_EquityMember" order="9.0"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_StatementOfChangesInEquityTable" xlink:to="ifrs-full_StatementOfChangesInEquityLineItems" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_Equity" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Equity"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_StatementOfChangesInEquityLineItems" xlink:to="ifrs-full_Equity" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_IssueOfEquity" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IssueOfEquity"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_StatementOfChangesInEquityLineItems" xlink:to="ifrs-full_IssueOfEquity" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="OptionsForfeitedcancelled" xlink:href="tlsa-20221231.xsd#tlsa_OptionsForfeitedcancelled"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_IssueOfEquity" xlink:to="OptionsForfeitedcancelled" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_IncreaseDecreaseThroughExerciseOfOptions" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncreaseDecreaseThroughExerciseOfOptions"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_IssueOfEquity" xlink:to="ifrs-full_IncreaseDecreaseThroughExerciseOfOptions" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="IssueOfShareCapitalLoanConversion" xlink:href="tlsa-20221231.xsd#tlsa_IssueOfShareCapitalLoanConversion"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_StatementOfChangesInEquityLineItems" xlink:to="IssueOfShareCapitalLoanConversion" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ShareBasedPaymentoptions" xlink:href="tlsa-20221231.xsd#tlsa_ShareBasedPaymentoptions"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_StatementOfChangesInEquityLineItems" xlink:to="ShareBasedPaymentoptions" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="SharesToBeIssuedInLieuOfCashRealizationBonus" xlink:href="tlsa-20221231.xsd#tlsa_SharesToBeIssuedInLieuOfCashRealizationBonus"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_StatementOfChangesInEquityLineItems" xlink:to="SharesToBeIssuedInLieuOfCashRealizationBonus" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_IncreaseDecreaseThroughTransactionsWithOwners" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncreaseDecreaseThroughTransactionsWithOwners"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_StatementOfChangesInEquityLineItems" xlink:to="ifrs-full_IncreaseDecreaseThroughTransactionsWithOwners" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_OtherComprehensiveIncome" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherComprehensiveIncome"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_StatementOfChangesInEquityLineItems" xlink:to="ifrs-full_OtherComprehensiveIncome" order="6.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ProfitLoss1" xlink:href="tlsa-20221231.xsd#tlsa_ProfitLoss1"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_StatementOfChangesInEquityLineItems" xlink:to="ProfitLoss1" order="7.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation1" xlink:href="tlsa-20221231.xsd#tlsa_OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation1"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_StatementOfChangesInEquityLineItems" xlink:to="OtherComprehensiveIncomeNetOfTaxExchangeDifferencesOnTranslation1" order="8.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ComprehensiveIncome1" xlink:href="tlsa-20221231.xsd#tlsa_ComprehensiveIncome1"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_StatementOfChangesInEquityLineItems" xlink:to="ComprehensiveIncome1" order="9.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_Equity_0" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Equity"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_StatementOfChangesInEquityLineItems" xlink:to="ifrs-full_Equity_0" order="10.0" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ConsolidatedCashFlow">
    <loc xlink:type="locator" xlink:label="ifrs-full_StatementOfCashFlowsAbstract" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_StatementOfCashFlowsAbstract"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_CashFlowsFromUsedInOperatingActivitiesAbstract" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivitiesAbstract"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_StatementOfCashFlowsAbstract" xlink:to="ifrs-full_CashFlowsFromUsedInOperatingActivitiesAbstract" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ProfitLossBeforeTax" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLossBeforeTax"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="ifrs-full_ProfitLossBeforeTax" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_AdjustmentsForReconcileProfitLossAbstract" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForReconcileProfitLossAbstract"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CashFlowsFromUsedInOperatingActivitiesAbstract" xlink:to="ifrs-full_AdjustmentsForReconcileProfitLossAbstract" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_AdjustmentsForInterestExpense" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForInterestExpense"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_AdjustmentsForReconcileProfitLossAbstract" xlink:to="ifrs-full_AdjustmentsForInterestExpense" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="SharesIssuedInLieuOfFees" xlink:href="tlsa-20221231.xsd#tlsa_SharesIssuedInLieuOfFees"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_AdjustmentsForReconcileProfitLossAbstract" xlink:to="SharesIssuedInLieuOfFees" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="AdjustmentsForForfeitureOfOptions" xlink:href="tlsa-20221231.xsd#tlsa_AdjustmentsForForfeitureOfOptions"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_AdjustmentsForReconcileProfitLossAbstract" xlink:to="AdjustmentsForForfeitureOfOptions" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="AdjustmentsForSharebasedPaymentsWarrants" xlink:href="tlsa-20221231.xsd#tlsa_AdjustmentsForSharebasedPaymentsWarrants"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_AdjustmentsForReconcileProfitLossAbstract" xlink:to="AdjustmentsForSharebasedPaymentsWarrants" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="FVLossOnInvestment" xlink:href="tlsa-20221231.xsd#tlsa_FVLossOnInvestment"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_AdjustmentsForReconcileProfitLossAbstract" xlink:to="FVLossOnInvestment" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="LossOnDisposalOfAsset" xlink:href="tlsa-20221231.xsd#tlsa_LossOnDisposalOfAsset"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_AdjustmentsForReconcileProfitLossAbstract" xlink:to="LossOnDisposalOfAsset" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="BonusToBeSettledInEquity" xlink:href="tlsa-20221231.xsd#tlsa_BonusToBeSettledInEquity"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_AdjustmentsForReconcileProfitLossAbstract" xlink:to="BonusToBeSettledInEquity" order="6.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_AdjustmentsForDepreciationExpense" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForDepreciationExpense"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_AdjustmentsForReconcileProfitLossAbstract" xlink:to="ifrs-full_AdjustmentsForDepreciationExpense" order="7.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationRecognisedInProfitOrLoss" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationRecognisedInProfitOrLoss"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_AdjustmentsForReconcileProfitLossAbstract" xlink:to="ifrs-full_GainsLossesOnExchangeDifferencesOnTranslationRecognisedInProfitOrLoss" order="8.0" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <loc xlink:type="locator" xlink:label="OptionsForfeitedDuringTheYear" xlink:href="tlsa-20221231.xsd#tlsa_OptionsForfeitedDuringTheYear"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_AdjustmentsForReconcileProfitLossAbstract" xlink:to="OptionsForfeitedDuringTheYear" order="9.0" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <loc xlink:type="locator" xlink:label="DepreciationOfRightofuseAsset" xlink:href="tlsa-20221231.xsd#tlsa_DepreciationOfRightofuseAsset"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_AdjustmentsForReconcileProfitLossAbstract" xlink:to="DepreciationOfRightofuseAsset" order="10.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ProfitsLossesOnDisposalOfInvestmentsAndChangesInValueOfInvestments" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitsLossesOnDisposalOfInvestmentsAndChangesInValueOfInvestments"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_AdjustmentsForReconcileProfitLossAbstract" xlink:to="ifrs-full_ProfitsLossesOnDisposalOfInvestmentsAndChangesInValueOfInvestments" order="11.0" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <loc xlink:type="locator" xlink:label="ProceedsFromSaleAndCollectionOfFinanceReceivable" xlink:href="tlsa-20221231.xsd#tlsa_ProceedsFromSaleAndCollectionOfFinanceReceivable"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_AdjustmentsForReconcileProfitLossAbstract" xlink:to="ProceedsFromSaleAndCollectionOfFinanceReceivable" order="12.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_AdjustmentsForReconcileProfitLossAbstract" xlink:to="ifrs-full_IncomeTaxesPaidRefundClassifiedAsOperatingActivities" order="13.0" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <loc xlink:type="locator" xlink:label="ImpairmentCharges" xlink:href="tlsa-20221231.xsd#tlsa_ImpairmentCharges"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_AdjustmentsForReconcileProfitLossAbstract" xlink:to="ImpairmentCharges" order="14.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="CapitalDistribution" xlink:href="tlsa-20221231.xsd#tlsa_CapitalDistribution"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_AdjustmentsForReconcileProfitLossAbstract" xlink:to="CapitalDistribution" order="15.0" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <loc xlink:type="locator" xlink:label="NetIncreaseInRelatedPartyReceivables" xlink:href="tlsa-20221231.xsd#tlsa_NetIncreaseInRelatedPartyReceivables"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_AdjustmentsForReconcileProfitLossAbstract" xlink:to="NetIncreaseInRelatedPartyReceivables" order="16.0" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <loc xlink:type="locator" xlink:label="NetIncreaseInRelatedPartyPayables" xlink:href="tlsa-20221231.xsd#tlsa_NetIncreaseInRelatedPartyPayables"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_AdjustmentsForReconcileProfitLossAbstract" xlink:to="NetIncreaseInRelatedPartyPayables" order="17.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_AdjustmentsForDecreaseIncreaseInOtherOperatingReceivables" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForDecreaseIncreaseInOtherOperatingReceivables"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_AdjustmentsForReconcileProfitLossAbstract" xlink:to="ifrs-full_AdjustmentsForDecreaseIncreaseInOtherOperatingReceivables" order="18.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_AdjustmentsForIncreaseDecreaseInOtherLiabilities" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForIncreaseDecreaseInOtherLiabilities"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_AdjustmentsForReconcileProfitLossAbstract" xlink:to="ifrs-full_AdjustmentsForIncreaseDecreaseInOtherLiabilities" order="19.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_CashFlowsFromUsedInOperatingActivities" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsFromUsedInOperatingActivities"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_AdjustmentsForIncreaseDecreaseInOtherLiabilities" xlink:to="ifrs-full_CashFlowsFromUsedInOperatingActivities" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_CashFlowsFromUsedInInvestingActivitiesAbstract" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivitiesAbstract"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_StatementOfCashFlowsAbstract" xlink:to="ifrs-full_CashFlowsFromUsedInInvestingActivitiesAbstract" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CashFlowsFromUsedInInvestingActivitiesAbstract" xlink:to="ifrs-full_PurchaseOfPropertyPlantAndEquipmentClassifiedAsInvestingActivities" order="0.0" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <loc xlink:type="locator" xlink:label="PurchaseOfActD" xlink:href="tlsa-20221231.xsd#tlsa_PurchaseOfActD"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CashFlowsFromUsedInInvestingActivitiesAbstract" xlink:to="PurchaseOfActD" order="1.0" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <loc xlink:type="locator" xlink:label="ProceedsFromFinanceLease" xlink:href="tlsa-20221231.xsd#tlsa_ProceedsFromFinanceLease"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CashFlowsFromUsedInInvestingActivitiesAbstract" xlink:to="ProceedsFromFinanceLease" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="InvestmentInRelatedParty" xlink:href="tlsa-20221231.xsd#tlsa_InvestmentInRelatedParty"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CashFlowsFromUsedInInvestingActivitiesAbstract" xlink:to="InvestmentInRelatedParty" order="3.0" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <loc xlink:type="locator" xlink:label="PurchaseOfTreasuryAmount" xlink:href="tlsa-20221231.xsd#tlsa_PurchaseOfTreasuryAmount"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CashFlowsFromUsedInInvestingActivitiesAbstract" xlink:to="PurchaseOfTreasuryAmount" order="4.0" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_CashFlowsFromUsedInInvestingActivities" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsFromUsedInInvestingActivities"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="PurchaseOfTreasuryAmount" xlink:to="ifrs-full_CashFlowsFromUsedInInvestingActivities" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_CashFlowsFromUsedInFinancingActivitiesAbstract" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivitiesAbstract"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_StatementOfCashFlowsAbstract" xlink:to="ifrs-full_CashFlowsFromUsedInFinancingActivitiesAbstract" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="FundraisingCost" xlink:href="tlsa-20221231.xsd#tlsa_FundraisingCost"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CashFlowsFromUsedInFinancingActivitiesAbstract" xlink:to="FundraisingCost" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ProceedsFromIssueOfBondsNotesAndDebentures" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProceedsFromIssueOfBondsNotesAndDebentures"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CashFlowsFromUsedInFinancingActivitiesAbstract" xlink:to="ifrs-full_ProceedsFromIssueOfBondsNotesAndDebentures" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ProceedsFromIssuanceOfWarrant" xlink:href="tlsa-20221231.xsd#tlsa_ProceedsFromIssuanceOfWarrant"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CashFlowsFromUsedInFinancingActivitiesAbstract" xlink:to="ProceedsFromIssuanceOfWarrant" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ProceedsFromIssuanceOfOptions" xlink:href="tlsa-20221231.xsd#tlsa_ProceedsFromIssuanceOfOptions"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CashFlowsFromUsedInFinancingActivitiesAbstract" xlink:to="ProceedsFromIssuanceOfOptions" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="RepaymentOfLeasingLiabilities" xlink:href="tlsa-20221231.xsd#tlsa_RepaymentOfLeasingLiabilities"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CashFlowsFromUsedInFinancingActivitiesAbstract" xlink:to="RepaymentOfLeasingLiabilities" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_CashFlowsFromUsedInFinancingActivities" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashFlowsFromUsedInFinancingActivities"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RepaymentOfLeasingLiabilities" xlink:to="ifrs-full_CashFlowsFromUsedInFinancingActivities" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_StatementOfCashFlowsAbstract" xlink:to="ifrs-full_IncreaseDecreaseInCashAndCashEquivalentsBeforeEffectOfExchangeRateChanges" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_CashAndCashEquivalents" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashAndCashEquivalents"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_StatementOfCashFlowsAbstract" xlink:to="ifrs-full_CashAndCashEquivalents" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_EffectOfExchangeRateChangesOnCashAndCashEquivalents" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_EffectOfExchangeRateChangesOnCashAndCashEquivalents"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_StatementOfCashFlowsAbstract" xlink:to="ifrs-full_EffectOfExchangeRateChangesOnCashAndCashEquivalents" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_CashAndCashEquivalents_0" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashAndCashEquivalents"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_StatementOfCashFlowsAbstract" xlink:to="ifrs-full_CashAndCashEquivalents_0" order="6.0" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/GeneralInformation">
    <loc xlink:type="locator" xlink:label="DisclosureOfGeneralInformationAboutFinancialStatementsAndOrganizationAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfGeneralInformationAboutFinancialStatementsAndOrganizationAbstract"/>
    <loc xlink:type="locator" xlink:label="GeneralInformationTable" xlink:href="tlsa-20221231.xsd#tlsa_GeneralInformationTable"/>
    <loc xlink:type="locator" xlink:label="GeneralInformationLineItems" xlink:href="tlsa-20221231.xsd#tlsa_GeneralInformationLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfGeneralInformationAboutFinancialStatementsAndOrganizationAbstract" xlink:to="GeneralInformationTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="GeneralInformationTable" xlink:to="GeneralInformationLineItems" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="DisclosureOfGeneralInformationAboutFinancialStatementsAndOrganization" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfGeneralInformationAboutFinancialStatementsAndOrganization"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="GeneralInformationLineItems" xlink:to="DisclosureOfGeneralInformationAboutFinancialStatementsAndOrganization" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/AccountingPolicies">
    <loc xlink:type="locator" xlink:label="DisclosureOfSignificantAccountingPoliciesTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfSignificantAccountingPoliciesTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="AccountingPoliciesTable" xlink:href="tlsa-20221231.xsd#tlsa_AccountingPoliciesTable"/>
    <loc xlink:type="locator" xlink:label="AccountingPoliciesLineItems" xlink:href="tlsa-20221231.xsd#tlsa_AccountingPoliciesLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfSignificantAccountingPoliciesTextBlockAbstract" xlink:to="AccountingPoliciesTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="AccountingPoliciesTable" xlink:to="AccountingPoliciesLineItems" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DisclosureOfSummaryOfSignificantAccountingPoliciesExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfSummaryOfSignificantAccountingPoliciesExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="AccountingPoliciesLineItems" xlink:to="ifrs-full_DisclosureOfSummaryOfSignificantAccountingPoliciesExplanatory" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/CriticalAccountingJudgement">
    <loc xlink:type="locator" xlink:label="ifrs-full_DisclosureOfChangesInAccountingEstimatesLineItems" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfChangesInAccountingEstimatesLineItems"/>
    <loc xlink:type="locator" xlink:label="CriticalAccountingJudgementTable" xlink:href="tlsa-20221231.xsd#tlsa_CriticalAccountingJudgementTable"/>
    <loc xlink:type="locator" xlink:label="CriticalAccountingJudgementLineItems" xlink:href="tlsa-20221231.xsd#tlsa_CriticalAccountingJudgementLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_DisclosureOfChangesInAccountingEstimatesLineItems" xlink:to="CriticalAccountingJudgementTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CriticalAccountingJudgementTable" xlink:to="CriticalAccountingJudgementLineItems" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DescriptionOfNatureAndAmountOfChangeInAccountingEstimate" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfNatureAndAmountOfChangeInAccountingEstimate"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CriticalAccountingJudgementLineItems" xlink:to="ifrs-full_DescriptionOfNatureAndAmountOfChangeInAccountingEstimate" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/OtherexpenseIncome">
    <loc xlink:type="locator" xlink:label="DisclosureOfOtherOperatingIncomeTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfOtherOperatingIncomeTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="OtherexpenseIncomeTable" xlink:href="tlsa-20221231.xsd#tlsa_OtherexpenseIncomeTable"/>
    <loc xlink:type="locator" xlink:label="OtherexpenseIncomeLineItems" xlink:href="tlsa-20221231.xsd#tlsa_OtherexpenseIncomeLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfOtherOperatingIncomeTextBlockAbstract" xlink:to="OtherexpenseIncomeTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OtherexpenseIncomeTable" xlink:to="OtherexpenseIncomeLineItems" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DisclosureOfOtherOperatingIncomeExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfOtherOperatingIncomeExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OtherexpenseIncomeLineItems" xlink:to="ifrs-full_DisclosureOfOtherOperatingIncomeExplanatory" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/OperatingLoss">
    <loc xlink:type="locator" xlink:label="DisclosureOfProfitLossFromOperatingActivitiesTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfProfitLossFromOperatingActivitiesTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="OperatingLossTable" xlink:href="tlsa-20221231.xsd#tlsa_OperatingLossTable"/>
    <loc xlink:type="locator" xlink:label="OperatingLossLineItems" xlink:href="tlsa-20221231.xsd#tlsa_OperatingLossLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfProfitLossFromOperatingActivitiesTextBlockAbstract" xlink:to="OperatingLossTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OperatingLossTable" xlink:to="OperatingLossLineItems" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DisclosureOfProfitLossFromOperatingActivitiesExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfProfitLossFromOperatingActivitiesExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OperatingLossLineItems" xlink:to="ifrs-full_DisclosureOfProfitLossFromOperatingActivitiesExplanatory" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/SegmentalReporting">
    <loc xlink:type="locator" xlink:label="DescriptionOfSegmentReportingExplanatoryAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DescriptionOfSegmentReportingExplanatoryAbstract"/>
    <loc xlink:type="locator" xlink:label="SegmentalReportingTable" xlink:href="tlsa-20221231.xsd#tlsa_SegmentalReportingTable"/>
    <loc xlink:type="locator" xlink:label="SegmentalReportingLineItems" xlink:href="tlsa-20221231.xsd#tlsa_SegmentalReportingLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DescriptionOfSegmentReportingExplanatoryAbstract" xlink:to="SegmentalReportingTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="SegmentalReportingTable" xlink:to="SegmentalReportingLineItems" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="DescriptionOfSegmentReportingExplanatory" xlink:href="tlsa-20221231.xsd#tlsa_DescriptionOfSegmentReportingExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="SegmentalReportingLineItems" xlink:to="DescriptionOfSegmentReportingExplanatory" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/Employees">
    <loc xlink:type="locator" xlink:label="DisclosureOfInformationAboutEmployeesTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfInformationAboutEmployeesTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="EmployeesTable" xlink:href="tlsa-20221231.xsd#tlsa_EmployeesTable"/>
    <loc xlink:type="locator" xlink:label="EmployeesLineItems" xlink:href="tlsa-20221231.xsd#tlsa_EmployeesLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfInformationAboutEmployeesTextBlockAbstract" xlink:to="EmployeesTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="EmployeesTable" xlink:to="EmployeesLineItems" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DisclosureOfInformationAboutEmployeesExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfInformationAboutEmployeesExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="EmployeesLineItems" xlink:to="ifrs-full_DisclosureOfInformationAboutEmployeesExplanatory" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/RemunerationofKeyManagementPersonnel">
    <loc xlink:type="locator" xlink:label="DisclosureOfInformationAboutKeyManagementPersonnelTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfInformationAboutKeyManagementPersonnelTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="RemunerationofKeyManagementPersonnelTable" xlink:href="tlsa-20221231.xsd#tlsa_RemunerationofKeyManagementPersonnelTable"/>
    <loc xlink:type="locator" xlink:label="RemunerationofKeyManagementPersonnelLineItems" xlink:href="tlsa-20221231.xsd#tlsa_RemunerationofKeyManagementPersonnelLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfInformationAboutKeyManagementPersonnelTextBlockAbstract" xlink:to="RemunerationofKeyManagementPersonnelTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RemunerationofKeyManagementPersonnelTable" xlink:to="RemunerationofKeyManagementPersonnelLineItems" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DisclosureOfInformationAboutKeyManagementPersonnelExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfInformationAboutKeyManagementPersonnelExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RemunerationofKeyManagementPersonnelLineItems" xlink:to="ifrs-full_DisclosureOfInformationAboutKeyManagementPersonnelExplanatory" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/FinanceCosts">
    <loc xlink:type="locator" xlink:label="DisclosureOfFinanceCostTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfFinanceCostTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="FinanceCostsTable" xlink:href="tlsa-20221231.xsd#tlsa_FinanceCostsTable"/>
    <loc xlink:type="locator" xlink:label="FinanceCostsLineItems" xlink:href="tlsa-20221231.xsd#tlsa_FinanceCostsLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfFinanceCostTextBlockAbstract" xlink:to="FinanceCostsTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="FinanceCostsTable" xlink:to="FinanceCostsLineItems" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DisclosureOfFinanceCostExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfFinanceCostExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="FinanceCostsLineItems" xlink:to="ifrs-full_DisclosureOfFinanceCostExplanatory" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/Taxation">
    <loc xlink:type="locator" xlink:label="DisclosureOfIncomeTaxTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfIncomeTaxTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="TaxationTable" xlink:href="tlsa-20221231.xsd#tlsa_TaxationTable"/>
    <loc xlink:type="locator" xlink:label="TaxationLineItems" xlink:href="tlsa-20221231.xsd#tlsa_TaxationLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfIncomeTaxTextBlockAbstract" xlink:to="TaxationTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="TaxationTable" xlink:to="TaxationLineItems" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DisclosureOfIncomeTaxExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfIncomeTaxExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="TaxationLineItems" xlink:to="ifrs-full_DisclosureOfIncomeTaxExplanatory" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/LossPerShare">
    <loc xlink:type="locator" xlink:label="DisclosureOfEarningsPerShareTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfEarningsPerShareTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DisclosureOfEarningsPerShareExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfEarningsPerShareExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfEarningsPerShareTextBlockAbstract" xlink:to="ifrs-full_DisclosureOfEarningsPerShareExplanatory" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/OtherReceivables">
    <loc xlink:type="locator" xlink:label="DisclosureOfTradeAndOtherReceivablesTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfTradeAndOtherReceivablesTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="OtherReceivablesTable" xlink:href="tlsa-20221231.xsd#tlsa_OtherReceivablesTable"/>
    <loc xlink:type="locator" xlink:label="OtherReceivablesLineItems" xlink:href="tlsa-20221231.xsd#tlsa_OtherReceivablesLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfTradeAndOtherReceivablesTextBlockAbstract" xlink:to="OtherReceivablesTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OtherReceivablesTable" xlink:to="OtherReceivablesLineItems" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DisclosureOfTradeAndOtherReceivablesExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfTradeAndOtherReceivablesExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OtherReceivablesLineItems" xlink:to="ifrs-full_DisclosureOfTradeAndOtherReceivablesExplanatory" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ShareCapitalandSharePremium">
    <loc xlink:type="locator" xlink:label="DisclosureOfShareCapitalReservesAndOtherEquityInterestTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfShareCapitalReservesAndOtherEquityInterestTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DisclosureOfShareCapitalReservesAndOtherEquityInterestExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfShareCapitalReservesAndOtherEquityInterestExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfShareCapitalReservesAndOtherEquityInterestTextBlockAbstract" xlink:to="ifrs-full_DisclosureOfShareCapitalReservesAndOtherEquityInterestExplanatory" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ShareBasedPayments">
    <loc xlink:type="locator" xlink:label="DisclosureOfShareBasedPaymentArrangementsTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfShareBasedPaymentArrangementsTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="ShareBasedPaymentsTable" xlink:href="tlsa-20221231.xsd#tlsa_ShareBasedPaymentsTable"/>
    <loc xlink:type="locator" xlink:label="ShareBasedPaymentsLineItems" xlink:href="tlsa-20221231.xsd#tlsa_ShareBasedPaymentsLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfShareBasedPaymentArrangementsTextBlockAbstract" xlink:to="ShareBasedPaymentsTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareBasedPaymentsTable" xlink:to="ShareBasedPaymentsLineItems" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DisclosureOfSharebasedPaymentArrangementsExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfSharebasedPaymentArrangementsExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareBasedPaymentsLineItems" xlink:to="ifrs-full_DisclosureOfSharebasedPaymentArrangementsExplanatory" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/Reserves">
    <loc xlink:type="locator" xlink:label="DisclosureOfReservesAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfReservesAbstract"/>
    <loc xlink:type="locator" xlink:label="DisclosureOfReservesTextBlock" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfReservesTextBlock"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfReservesAbstract" xlink:to="DisclosureOfReservesTextBlock" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/FinancialInstruments">
    <loc xlink:type="locator" xlink:label="DisclosureOfFinancialInstrumentsTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfFinancialInstrumentsTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DisclosureOfFinancialInstrumentsExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfFinancialInstrumentsExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfFinancialInstrumentsTextBlockAbstract" xlink:to="ifrs-full_DisclosureOfFinancialInstrumentsExplanatory" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/CapitalRiskManagement">
    <loc xlink:type="locator" xlink:label="DisclosureOfFinancialRiskManagementTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfFinancialRiskManagementTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="CapitalRiskManagementTable" xlink:href="tlsa-20221231.xsd#tlsa_CapitalRiskManagementTable"/>
    <loc xlink:type="locator" xlink:label="CapitalRiskManagementLineItems" xlink:href="tlsa-20221231.xsd#tlsa_CapitalRiskManagementLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfFinancialRiskManagementTextBlockAbstract" xlink:to="CapitalRiskManagementTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CapitalRiskManagementTable" xlink:to="CapitalRiskManagementLineItems" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DisclosureOfFinancialRiskManagementExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfFinancialRiskManagementExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="CapitalRiskManagementLineItems" xlink:to="ifrs-full_DisclosureOfFinancialRiskManagementExplanatory" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/TradeandOtherPayables">
    <loc xlink:type="locator" xlink:label="DisclosureOfTradeAndOtherPayablesTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfTradeAndOtherPayablesTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="TradeandOtherPayablesTable" xlink:href="tlsa-20221231.xsd#tlsa_TradeandOtherPayablesTable"/>
    <loc xlink:type="locator" xlink:label="TradeandOtherPayablesLineItems" xlink:href="tlsa-20221231.xsd#tlsa_TradeandOtherPayablesLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfTradeAndOtherPayablesTextBlockAbstract" xlink:to="TradeandOtherPayablesTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="TradeandOtherPayablesTable" xlink:to="TradeandOtherPayablesLineItems" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DisclosureOfTradeAndOtherPayablesExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfTradeAndOtherPayablesExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="TradeandOtherPayablesLineItems" xlink:to="ifrs-full_DisclosureOfTradeAndOtherPayablesExplanatory" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/InvestmentinRelatedParty">
    <loc xlink:type="locator" xlink:label="InvestmentInRelatedPartyAbstract" xlink:href="tlsa-20221231.xsd#tlsa_InvestmentInRelatedPartyAbstract"/>
    <loc xlink:type="locator" xlink:label="InvestmentinRelatedPartyTable" xlink:href="tlsa-20221231.xsd#tlsa_InvestmentinRelatedPartyTable"/>
    <loc xlink:type="locator" xlink:label="InvestmentinRelatedPartyLineItems" xlink:href="tlsa-20221231.xsd#tlsa_InvestmentinRelatedPartyLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="InvestmentInRelatedPartyAbstract" xlink:to="InvestmentinRelatedPartyTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="InvestmentinRelatedPartyTable" xlink:to="InvestmentinRelatedPartyLineItems" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="InvestmentInRelatedPartyTextBlock" xlink:href="tlsa-20221231.xsd#tlsa_InvestmentInRelatedPartyTextBlock"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="InvestmentinRelatedPartyLineItems" xlink:to="InvestmentInRelatedPartyTextBlock" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/TreasuryShares">
    <loc xlink:type="locator" xlink:label="DisclosureOfTreasurySharesTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfTreasurySharesTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DisclosureOfTreasurySharesExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfTreasurySharesExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfTreasurySharesTextBlockAbstract" xlink:to="ifrs-full_DisclosureOfTreasurySharesExplanatory" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/RelatedPartyTransactions">
    <loc xlink:type="locator" xlink:label="DisclosureOfRelatedPartyTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfRelatedPartyTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DisclosureOfRelatedPartyExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfRelatedPartyExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfRelatedPartyTextBlockAbstract" xlink:to="ifrs-full_DisclosureOfRelatedPartyExplanatory" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/Leases">
    <loc xlink:type="locator" xlink:label="DisclosureOfLeasesTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfLeasesTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="LeasesTable" xlink:href="tlsa-20221231.xsd#tlsa_LeasesTable"/>
    <loc xlink:type="locator" xlink:label="LeasesLineItems" xlink:href="tlsa-20221231.xsd#tlsa_LeasesLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfLeasesTextBlockAbstract" xlink:to="LeasesTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LeasesTable" xlink:to="LeasesLineItems" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DisclosureOfLeasesExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfLeasesExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LeasesLineItems" xlink:to="ifrs-full_DisclosureOfLeasesExplanatory" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/FinancialCommitments">
    <loc xlink:type="locator" xlink:label="DisclosureOfCommitmentsTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfCommitmentsTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DisclosureOfCommitmentsExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfCommitmentsExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfCommitmentsTextBlockAbstract" xlink:to="ifrs-full_DisclosureOfCommitmentsExplanatory" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ContingentLiabilities">
    <loc xlink:type="locator" xlink:label="DisclosureOfCommitmentsAndContingentLiabilitiesTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfCommitmentsAndContingentLiabilitiesTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DisclosureOfCommitmentsAndContingentLiabilitiesExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfCommitmentsAndContingentLiabilitiesExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfCommitmentsAndContingentLiabilitiesTextBlockAbstract" xlink:to="ifrs-full_DisclosureOfCommitmentsAndContingentLiabilitiesExplanatory" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/PostBalanceSheetEvents">
    <loc xlink:type="locator" xlink:label="DisclosureOfEventsAfterReportingPeriodTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfEventsAfterReportingPeriodTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DisclosureOfEventsAfterReportingPeriodExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfEventsAfterReportingPeriodExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfEventsAfterReportingPeriodTextBlockAbstract" xlink:to="ifrs-full_DisclosureOfEventsAfterReportingPeriodExplanatory" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/AccountingPoliciesByPolicy">
    <loc xlink:type="locator" xlink:label="us-gaap_AccountingPoliciesAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <loc xlink:type="locator" xlink:label="TheDisclosureOfBasisOfPreparation" xlink:href="tlsa-20221231.xsd#tlsa_TheDisclosureOfBasisOfPreparation"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_AccountingPoliciesAbstract" xlink:to="TheDisclosureOfBasisOfPreparation" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="DescriptionOfAccountingPolicyForGoingConcern" xlink:href="tlsa-20221231.xsd#tlsa_DescriptionOfAccountingPolicyForGoingConcern"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_AccountingPoliciesAbstract" xlink:to="DescriptionOfAccountingPolicyForGoingConcern" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DisclosureOfChangesInAccountingPoliciesExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfChangesInAccountingPoliciesExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_AccountingPoliciesAbstract" xlink:to="ifrs-full_DisclosureOfChangesInAccountingPoliciesExplanatory" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="DescriptionOfAccountingPolicyForBasisofConsolidation" xlink:href="tlsa-20221231.xsd#tlsa_DescriptionOfAccountingPolicyForBasisofConsolidation"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_AccountingPoliciesAbstract" xlink:to="DescriptionOfAccountingPolicyForBasisofConsolidation" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DescriptionOfAccountingPolicyForBusinessCombinationsExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForBusinessCombinationsExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_AccountingPoliciesAbstract" xlink:to="ifrs-full_DescriptionOfAccountingPolicyForBusinessCombinationsExplanatory" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DescriptionOfAccountingPolicyForSegmentReportingExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForSegmentReportingExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_AccountingPoliciesAbstract" xlink:to="ifrs-full_DescriptionOfAccountingPolicyForSegmentReportingExplanatory" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DescriptionOfAccountingPolicyForTaxesOtherThanIncomeTaxExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForTaxesOtherThanIncomeTaxExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_AccountingPoliciesAbstract" xlink:to="ifrs-full_DescriptionOfAccountingPolicyForTaxesOtherThanIncomeTaxExplanatory" order="6.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DescriptionOfAccountingPolicyForForeignCurrencyTranslationExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForForeignCurrencyTranslationExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_AccountingPoliciesAbstract" xlink:to="ifrs-full_DescriptionOfAccountingPolicyForForeignCurrencyTranslationExplanatory" order="7.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="DescriptionOfAccountingPolicyForLicenseFees" xlink:href="tlsa-20221231.xsd#tlsa_DescriptionOfAccountingPolicyForLicenseFees"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_AccountingPoliciesAbstract" xlink:to="DescriptionOfAccountingPolicyForLicenseFees" order="8.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DescriptionOfAccountingPolicyForResearchAndDevelopmentExpenseExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForResearchAndDevelopmentExpenseExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_AccountingPoliciesAbstract" xlink:to="ifrs-full_DescriptionOfAccountingPolicyForResearchAndDevelopmentExpenseExplanatory" order="9.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_AccountingPoliciesAbstract" xlink:to="ifrs-full_DescriptionOfAccountingPolicyForFinancialInstrumentsExplanatory" order="10.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="WarrantsPolicyTextBlock" xlink:href="tlsa-20221231.xsd#tlsa_WarrantsPolicyTextBlock"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_AccountingPoliciesAbstract" xlink:to="WarrantsPolicyTextBlock" order="11.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DescriptionOfAccountingPolicyForIssuedCapitalExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForIssuedCapitalExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_AccountingPoliciesAbstract" xlink:to="ifrs-full_DescriptionOfAccountingPolicyForIssuedCapitalExplanatory" order="12.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DescriptionOfAccountingPolicyForPropertyPlantAndEquipmentExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForPropertyPlantAndEquipmentExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_AccountingPoliciesAbstract" xlink:to="ifrs-full_DescriptionOfAccountingPolicyForPropertyPlantAndEquipmentExplanatory" order="13.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfAssetsExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfAssetsExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_AccountingPoliciesAbstract" xlink:to="ifrs-full_DescriptionOfAccountingPolicyForImpairmentOfAssetsExplanatory" order="14.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DescriptionOfAccountingPolicyForLeasesExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForLeasesExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_AccountingPoliciesAbstract" xlink:to="ifrs-full_DescriptionOfAccountingPolicyForLeasesExplanatory" order="15.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DescriptionOfAccountingPolicyForSharebasedPaymentTransactionsExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForSharebasedPaymentTransactionsExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_AccountingPoliciesAbstract" xlink:to="ifrs-full_DescriptionOfAccountingPolicyForSharebasedPaymentTransactionsExplanatory" order="16.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="SubLicenseIncomePolicyTextBlock" xlink:href="tlsa-20221231.xsd#tlsa_SubLicenseIncomePolicyTextBlock"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_AccountingPoliciesAbstract" xlink:to="SubLicenseIncomePolicyTextBlock" order="17.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DescriptionOfAccountingPolicyForIntangibleAssetsOtherThanGoodwillExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForIntangibleAssetsOtherThanGoodwillExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_AccountingPoliciesAbstract" xlink:to="ifrs-full_DescriptionOfAccountingPolicyForIntangibleAssetsOtherThanGoodwillExplanatory" order="18.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DescriptionOfAccountingPolicyForContingentLiabilitiesAndContingentAssetsExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForContingentLiabilitiesAndContingentAssetsExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_AccountingPoliciesAbstract" xlink:to="ifrs-full_DescriptionOfAccountingPolicyForContingentLiabilitiesAndContingentAssetsExplanatory" order="19.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DescriptionOfAccountingPolicyForFairValueMeasurementExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfAccountingPolicyForFairValueMeasurementExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="us-gaap_AccountingPoliciesAbstract" xlink:to="ifrs-full_DescriptionOfAccountingPolicyForFairValueMeasurementExplanatory" order="20.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/AccountingPoliciesTables">
    <loc xlink:type="locator" xlink:label="DisclosureOfSignificantAccountingPoliciesTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfSignificantAccountingPoliciesTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="AccountingPoliciesTablesTable" xlink:href="tlsa-20221231.xsd#tlsa_AccountingPoliciesTablesTable"/>
    <loc xlink:type="locator" xlink:label="AccountingPoliciesTablesLineItems" xlink:href="tlsa-20221231.xsd#tlsa_AccountingPoliciesTablesLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfSignificantAccountingPoliciesTextBlockAbstract" xlink:to="AccountingPoliciesTablesTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="AccountingPoliciesTablesTable" xlink:to="AccountingPoliciesTablesLineItems" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="DisclosureOfDetailedInformationAboutEstimatedUsefulLives" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfDetailedInformationAboutEstimatedUsefulLives"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="AccountingPoliciesTablesLineItems" xlink:to="DisclosureOfDetailedInformationAboutEstimatedUsefulLives" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/OtherexpenseIncomeTables">
    <loc xlink:type="locator" xlink:label="DisclosureOfOtherOperatingIncomeTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfOtherOperatingIncomeTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="OtherexpenseIncomeTablesTable" xlink:href="tlsa-20221231.xsd#tlsa_OtherexpenseIncomeTablesTable"/>
    <loc xlink:type="locator" xlink:label="OtherexpenseIncomeTablesLineItems" xlink:href="tlsa-20221231.xsd#tlsa_OtherexpenseIncomeTablesLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfOtherOperatingIncomeTextBlockAbstract" xlink:to="OtherexpenseIncomeTablesTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OtherexpenseIncomeTablesTable" xlink:to="OtherexpenseIncomeTablesLineItems" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DisclosureOfOtherOperatingIncomeExpenseExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfOtherOperatingIncomeExpenseExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OtherexpenseIncomeTablesLineItems" xlink:to="ifrs-full_DisclosureOfOtherOperatingIncomeExpenseExplanatory" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/OperatingLossTables">
    <loc xlink:type="locator" xlink:label="DisclosureOfProfitLossFromOperatingActivitiesTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfProfitLossFromOperatingActivitiesTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="OperatingLossTablesTable" xlink:href="tlsa-20221231.xsd#tlsa_OperatingLossTablesTable"/>
    <loc xlink:type="locator" xlink:label="OperatingLossTablesLineItems" xlink:href="tlsa-20221231.xsd#tlsa_OperatingLossTablesLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfProfitLossFromOperatingActivitiesTextBlockAbstract" xlink:to="OperatingLossTablesTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OperatingLossTablesTable" xlink:to="OperatingLossTablesLineItems" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="DisclosureOfDetailedInformationAboutOperatingLoss" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfDetailedInformationAboutOperatingLoss"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OperatingLossTablesLineItems" xlink:to="DisclosureOfDetailedInformationAboutOperatingLoss" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/EmployeesTables">
    <loc xlink:type="locator" xlink:label="DisclosureOfInformationAboutEmployeesTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfInformationAboutEmployeesTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="DisclosureOfDetailedInformationAboutEmployeesExplanatory" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfDetailedInformationAboutEmployeesExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfInformationAboutEmployeesTextBlockAbstract" xlink:to="DisclosureOfDetailedInformationAboutEmployeesExplanatory" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/RemunerationofKeyManagementPersonnelTables">
    <loc xlink:type="locator" xlink:label="DisclosureOfInformationAboutKeyManagementPersonnelTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfInformationAboutKeyManagementPersonnelTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="DisclosureOfDetailedInformationAboutRemunerationOfKeyManagementPersonnelTextBlock" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfDetailedInformationAboutRemunerationOfKeyManagementPersonnelTextBlock"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfInformationAboutKeyManagementPersonnelTextBlockAbstract" xlink:to="DisclosureOfDetailedInformationAboutRemunerationOfKeyManagementPersonnelTextBlock" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="DisclosureOfShareOptionsWereGrantedToDirectorsTextBlock" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfShareOptionsWereGrantedToDirectorsTextBlock"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfInformationAboutKeyManagementPersonnelTextBlockAbstract" xlink:to="DisclosureOfShareOptionsWereGrantedToDirectorsTextBlock" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/FinanceCostsTables">
    <loc xlink:type="locator" xlink:label="DisclosureOfFinanceCostTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfFinanceCostTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="FinanceCostsTablesTable" xlink:href="tlsa-20221231.xsd#tlsa_FinanceCostsTablesTable"/>
    <loc xlink:type="locator" xlink:label="FinanceCostsTablesLineItems" xlink:href="tlsa-20221231.xsd#tlsa_FinanceCostsTablesLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfFinanceCostTextBlockAbstract" xlink:to="FinanceCostsTablesTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="FinanceCostsTablesTable" xlink:to="FinanceCostsTablesLineItems" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="DisclosureDetailedInformationAboutOfFinanceCostTableTextBlock" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureDetailedInformationAboutOfFinanceCostTableTextBlock"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="FinanceCostsTablesLineItems" xlink:to="DisclosureDetailedInformationAboutOfFinanceCostTableTextBlock" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/TaxationTables">
    <loc xlink:type="locator" xlink:label="DisclosureOfIncomeTaxTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfIncomeTaxTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="DisclosureOfDetailedInformationAboutIncomeTaxExpenseBenefitTableTextBlock" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfDetailedInformationAboutIncomeTaxExpenseBenefitTableTextBlock"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfIncomeTaxTextBlockAbstract" xlink:to="DisclosureOfDetailedInformationAboutIncomeTaxExpenseBenefitTableTextBlock" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/LossPerShareTables">
    <loc xlink:type="locator" xlink:label="DisclosureOfEarningsPerShareTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfEarningsPerShareTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="DisclosureOfDetailedInformationAboutOfEarningsPerShareTableTextBlock" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfDetailedInformationAboutOfEarningsPerShareTableTextBlock"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfEarningsPerShareTextBlockAbstract" xlink:to="DisclosureOfDetailedInformationAboutOfEarningsPerShareTableTextBlock" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/OtherReceivablesTables">
    <loc xlink:type="locator" xlink:label="DisclosureOfTradeAndOtherReceivablesTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfTradeAndOtherReceivablesTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="OtherReceivablesTablesTable" xlink:href="tlsa-20221231.xsd#tlsa_OtherReceivablesTablesTable"/>
    <loc xlink:type="locator" xlink:label="OtherReceivablesTablesLineItems" xlink:href="tlsa-20221231.xsd#tlsa_OtherReceivablesTablesLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfTradeAndOtherReceivablesTextBlockAbstract" xlink:to="OtherReceivablesTablesTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OtherReceivablesTablesTable" xlink:to="OtherReceivablesTablesLineItems" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="DisclosureOfDetailedInformationAboutOtherReceivablesTableTextBlock" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfDetailedInformationAboutOtherReceivablesTableTextBlock"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OtherReceivablesTablesLineItems" xlink:to="DisclosureOfDetailedInformationAboutOtherReceivablesTableTextBlock" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ShareCapitalandSharePremiumTables">
    <loc xlink:type="locator" xlink:label="DisclosureOfShareCapitalReservesAndOtherEquityInterestTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfShareCapitalReservesAndOtherEquityInterestTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="DisclosureShareCapitalArisingForShareExchangetextBlock" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureShareCapitalArisingForShareExchangetextBlock"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfShareCapitalReservesAndOtherEquityInterestTextBlockAbstract" xlink:to="DisclosureShareCapitalArisingForShareExchangetextBlock" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ShareBasedPaymentsTables">
    <loc xlink:type="locator" xlink:label="DisclosureOfShareBasedPaymentArrangementsTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfShareBasedPaymentArrangementsTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DisclosureOfNumberAndWeightedAverageExercisePricesOfShareOptionsExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfNumberAndWeightedAverageExercisePricesOfShareOptionsExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfShareBasedPaymentArrangementsTextBlockAbstract" xlink:to="ifrs-full_DisclosureOfNumberAndWeightedAverageExercisePricesOfShareOptionsExplanatory" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ScheduleOfOutstandingFairValueChargeOfTheShareOptionInstrumentsTableTextBlock" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfOutstandingFairValueChargeOfTheShareOptionInstrumentsTableTextBlock"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfShareBasedPaymentArrangementsTextBlockAbstract" xlink:to="ScheduleOfOutstandingFairValueChargeOfTheShareOptionInstrumentsTableTextBlock" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ScheduleOfModelInputsForOptionsGrantedUnderTheBlackScholesValuationModelTableTextBlock" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfModelInputsForOptionsGrantedUnderTheBlackScholesValuationModelTableTextBlock"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfShareBasedPaymentArrangementsTextBlockAbstract" xlink:to="ScheduleOfModelInputsForOptionsGrantedUnderTheBlackScholesValuationModelTableTextBlock" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ScheduleOfEquityIncentivePlanTableTextBlock" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfEquityIncentivePlanTableTextBlock"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfShareBasedPaymentArrangementsTextBlockAbstract" xlink:to="ScheduleOfEquityIncentivePlanTableTextBlock" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ScheduleOfEstimatedTheFairValueOfWarrantsUsingTextBlock" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfEstimatedTheFairValueOfWarrantsUsingTextBlock"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfShareBasedPaymentArrangementsTextBlockAbstract" xlink:to="ScheduleOfEstimatedTheFairValueOfWarrantsUsingTextBlock" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/FinancialInstrumentsTables">
    <loc xlink:type="locator" xlink:label="DisclosureOfFinancialInstrumentsTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfFinancialInstrumentsTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="ScheduleOfFinancialLiabilitiesBasedOnContractualUndiscountedPaymentsTableTextBlock" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfFinancialLiabilitiesBasedOnContractualUndiscountedPaymentsTableTextBlock"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfFinancialInstrumentsTextBlockAbstract" xlink:to="ScheduleOfFinancialLiabilitiesBasedOnContractualUndiscountedPaymentsTableTextBlock" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ScheduleOfMeasurementOfTheFinancialInstrumentsTextBlock" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfMeasurementOfTheFinancialInstrumentsTextBlock"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfFinancialInstrumentsTextBlockAbstract" xlink:to="ScheduleOfMeasurementOfTheFinancialInstrumentsTextBlock" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/TradeandOtherPayablesTables">
    <loc xlink:type="locator" xlink:label="DisclosureOfTradeAndOtherPayablesTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfTradeAndOtherPayablesTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="TradeandOtherPayablesTablesTable" xlink:href="tlsa-20221231.xsd#tlsa_TradeandOtherPayablesTablesTable"/>
    <loc xlink:type="locator" xlink:label="TradeandOtherPayablesTablesLineItems" xlink:href="tlsa-20221231.xsd#tlsa_TradeandOtherPayablesTablesLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfTradeAndOtherPayablesTextBlockAbstract" xlink:to="TradeandOtherPayablesTablesTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="TradeandOtherPayablesTablesTable" xlink:to="TradeandOtherPayablesTablesLineItems" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ScheduleOfTradeAndOtherPayablesTableTextBlock" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfTradeAndOtherPayablesTableTextBlock"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="TradeandOtherPayablesTablesLineItems" xlink:to="ScheduleOfTradeAndOtherPayablesTableTextBlock" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/InvestmentinRelatedPartyTables">
    <loc xlink:type="locator" xlink:label="InvestmentInRelatedPartyAbstract" xlink:href="tlsa-20221231.xsd#tlsa_InvestmentInRelatedPartyAbstract"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DisclosureOfEffectOfChangeOfInvestmentEntityStatusOnFinancialStatementsExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfEffectOfChangeOfInvestmentEntityStatusOnFinancialStatementsExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="InvestmentInRelatedPartyAbstract" xlink:to="ifrs-full_DisclosureOfEffectOfChangeOfInvestmentEntityStatusOnFinancialStatementsExplanatory" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/LeasesTables">
    <loc xlink:type="locator" xlink:label="DisclosureOfLeasesTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfLeasesTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="DisclosureOfQuantitativeInformationAboutRightofuseAssetsTableTextBlock" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfQuantitativeInformationAboutRightofuseAssetsTableTextBlock"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfLeasesTextBlockAbstract" xlink:to="DisclosureOfQuantitativeInformationAboutRightofuseAssetsTableTextBlock" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DisclosureOfFinancialAssetsExplanatory" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DisclosureOfFinancialAssetsExplanatory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfLeasesTextBlockAbstract" xlink:to="ifrs-full_DisclosureOfFinancialAssetsExplanatory" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="DisclosureOfFutureMinimumLeasePayments" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfFutureMinimumLeasePayments"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfLeasesTextBlockAbstract" xlink:to="DisclosureOfFutureMinimumLeasePayments" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ScheduleofestimatedusefullivesforthecurrentperiodandthecomparativeperiodTable">
    <loc xlink:type="locator" xlink:label="ScheduleOfEstimatedUsefulLivesForTheCurrentPeriodAndTheComparativePeriodAbstract" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfEstimatedUsefulLivesForTheCurrentPeriodAndTheComparativePeriodAbstract"/>
    <loc xlink:type="locator" xlink:label="AccountingPoliciesDetailsScheduleofestimatedusefullivesforthecurrentperiodandthecomparativeperiodTable" xlink:href="tlsa-20221231.xsd#tlsa_AccountingPoliciesDetailsScheduleofestimatedusefullivesforthecurrentperiodandthecomparativeperiodTable"/>
    <loc xlink:type="locator" xlink:label="AccountingPoliciesDetailsScheduleofestimatedusefullivesforthecurrentperiodandthecomparativeperiodLineItems" xlink:href="tlsa-20221231.xsd#tlsa_AccountingPoliciesDetailsScheduleofestimatedusefullivesforthecurrentperiodandthecomparativeperiodLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfEstimatedUsefulLivesForTheCurrentPeriodAndTheComparativePeriodAbstract" xlink:to="AccountingPoliciesDetailsScheduleofestimatedusefullivesforthecurrentperiodandthecomparativeperiodTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ClassesOfPropertyPlantAndEquipmentAxis" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ClassesOfPropertyPlantAndEquipmentAxis"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="AccountingPoliciesDetailsScheduleofestimatedusefullivesforthecurrentperiodandthecomparativeperiodTable" xlink:to="ifrs-full_ClassesOfPropertyPlantAndEquipmentAxis" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_FixturesAndFittingsMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FixturesAndFittingsMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_ClassesOfPropertyPlantAndEquipmentAxis" xlink:to="ifrs-full_FixturesAndFittingsMember" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_CommunicationAndNetworkEquipmentMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CommunicationAndNetworkEquipmentMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_ClassesOfPropertyPlantAndEquipmentAxis" xlink:to="ifrs-full_CommunicationAndNetworkEquipmentMember" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="RightOfUseAssetMember" xlink:href="tlsa-20221231.xsd#tlsa_RightOfUseAssetMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_ClassesOfPropertyPlantAndEquipmentAxis" xlink:to="RightOfUseAssetMember" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="AccountingPoliciesDetailsScheduleofestimatedusefullivesforthecurrentperiodandthecomparativeperiodTable" xlink:to="AccountingPoliciesDetailsScheduleofestimatedusefullivesforthecurrentperiodandthecomparativeperiodLineItems" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="EstimatedUsefulLives" xlink:href="tlsa-20221231.xsd#tlsa_EstimatedUsefulLives"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="AccountingPoliciesDetailsScheduleofestimatedusefullivesforthecurrentperiodandthecomparativeperiodLineItems" xlink:to="EstimatedUsefulLives" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="RightOfUseAssetDescription" xlink:href="tlsa-20221231.xsd#tlsa_RightOfUseAssetDescription"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="AccountingPoliciesDetailsScheduleofestimatedusefullivesforthecurrentperiodandthecomparativeperiodLineItems" xlink:to="RightOfUseAssetDescription" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ScheduleofotherexpenseincomeTable">
    <loc xlink:type="locator" xlink:label="ScheduleOfOtherExpenseIncomeAbstract" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfOtherExpenseIncomeAbstract"/>
    <loc xlink:type="locator" xlink:label="OtherexpenseIncomeDetailsScheduleofotherexpenseincomeTable" xlink:href="tlsa-20221231.xsd#tlsa_OtherexpenseIncomeDetailsScheduleofotherexpenseincomeTable"/>
    <loc xlink:type="locator" xlink:label="OtherexpenseIncomeDetailsScheduleofotherexpenseincomeLineItems" xlink:href="tlsa-20221231.xsd#tlsa_OtherexpenseIncomeDetailsScheduleofotherexpenseincomeLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfOtherExpenseIncomeAbstract" xlink:to="OtherexpenseIncomeDetailsScheduleofotherexpenseincomeTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_SegmentsAxis" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SegmentsAxis"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OtherexpenseIncomeDetailsScheduleofotherexpenseincomeTable" xlink:to="ifrs-full_SegmentsAxis" order="1.0"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_SegmentsMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SegmentsMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_SegmentsAxis" xlink:to="ifrs-full_SegmentsMember" order="0.0"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OtherexpenseIncomeDetailsScheduleofotherexpenseincomeTable" xlink:to="OtherexpenseIncomeDetailsScheduleofotherexpenseincomeLineItems" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="SublicenseIncome" xlink:href="tlsa-20221231.xsd#tlsa_SublicenseIncome"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OtherexpenseIncomeDetailsScheduleofotherexpenseincomeLineItems" xlink:to="SublicenseIncome" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_OtherFinanceIncome" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherFinanceIncome"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OtherexpenseIncomeDetailsScheduleofotherexpenseincomeLineItems" xlink:to="ifrs-full_OtherFinanceIncome" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_NoncurrentFinancialAssetsAtFairValueThroughProfitOrLossMeasuredAsSuchInAccordanceWithExemptionForReacquisitionOfOwnEquityInstruments" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncurrentFinancialAssetsAtFairValueThroughProfitOrLossMeasuredAsSuchInAccordanceWithExemptionForReacquisitionOfOwnEquityInstruments"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OtherexpenseIncomeDetailsScheduleofotherexpenseincomeLineItems" xlink:to="ifrs-full_NoncurrentFinancialAssetsAtFairValueThroughProfitOrLossMeasuredAsSuchInAccordanceWithExemptionForReacquisitionOfOwnEquityInstruments" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="OtherIncomelosses" xlink:href="tlsa-20221231.xsd#tlsa_OtherIncomelosses"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OtherexpenseIncomeDetailsScheduleofotherexpenseincomeLineItems" xlink:to="OtherIncomelosses" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ScheduleofoperatinglossesTable">
    <loc xlink:type="locator" xlink:label="ScheduleOfOperatingLossesAbstract" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfOperatingLossesAbstract"/>
    <loc xlink:type="locator" xlink:label="OperatingLossDetailsScheduleofoperatinglossesTable" xlink:href="tlsa-20221231.xsd#tlsa_OperatingLossDetailsScheduleofoperatinglossesTable"/>
    <loc xlink:type="locator" xlink:label="OperatingLossDetailsScheduleofoperatinglossesLineItems" xlink:href="tlsa-20221231.xsd#tlsa_OperatingLossDetailsScheduleofoperatinglossesLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfOperatingLossesAbstract" xlink:to="OperatingLossDetailsScheduleofoperatinglossesTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_SegmentsAxis" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SegmentsAxis"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OperatingLossDetailsScheduleofoperatinglossesTable" xlink:to="ifrs-full_SegmentsAxis" order="1.0"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_SegmentsMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SegmentsMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_SegmentsAxis" xlink:to="ifrs-full_SegmentsMember" order="0.0"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OperatingLossDetailsScheduleofoperatinglossesTable" xlink:to="OperatingLossDetailsScheduleofoperatinglossesLineItems" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="Licensefee" xlink:href="tlsa-20221231.xsd#tlsa_Licensefee"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OperatingLossDetailsScheduleofoperatinglossesLineItems" xlink:to="Licensefee" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="RealizationBonus" xlink:href="tlsa-20221231.xsd#tlsa_RealizationBonus"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OperatingLossDetailsScheduleofoperatinglossesLineItems" xlink:to="RealizationBonus" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="OperatingLoss" xlink:href="tlsa-20221231.xsd#tlsa_OperatingLoss"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OperatingLossDetailsScheduleofoperatinglossesLineItems" xlink:to="OperatingLoss" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DepreciationExpense" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DepreciationExpense"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OperatingLossDetailsScheduleofoperatinglossesLineItems" xlink:to="ifrs-full_DepreciationExpense" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DepreciationRightofuseAssets" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DepreciationRightofuseAssets"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OperatingLossDetailsScheduleofoperatinglossesLineItems" xlink:to="ifrs-full_DepreciationRightofuseAssets" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ForeignExchangegainlosses" xlink:href="tlsa-20221231.xsd#tlsa_ForeignExchangegainlosses"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OperatingLossDetailsScheduleofoperatinglossesLineItems" xlink:to="ForeignExchangegainlosses" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ScheduleofemployeesTable">
    <loc xlink:type="locator" xlink:label="ScheduleOfEmployeesAbstract" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfEmployeesAbstract"/>
    <loc xlink:type="locator" xlink:label="StaffCostsComprisedAbstract" xlink:href="tlsa-20221231.xsd#tlsa_StaffCostsComprisedAbstract"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfEmployeesAbstract" xlink:to="StaffCostsComprisedAbstract" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DirectorsRemunerationExpense" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DirectorsRemunerationExpense"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="StaffCostsComprisedAbstract" xlink:to="ifrs-full_DirectorsRemunerationExpense" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_WagesAndSalaries" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_WagesAndSalaries"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="StaffCostsComprisedAbstract" xlink:to="ifrs-full_WagesAndSalaries" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_SocialSecurityContributions" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SocialSecurityContributions"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="StaffCostsComprisedAbstract" xlink:to="ifrs-full_SocialSecurityContributions" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="RecruitmentFees" xlink:href="tlsa-20221231.xsd#tlsa_RecruitmentFees"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="StaffCostsComprisedAbstract" xlink:to="RecruitmentFees" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ExpenseFromSharebasedPaymentTransactionsWithEmployees" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ExpenseFromSharebasedPaymentTransactionsWithEmployees"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="StaffCostsComprisedAbstract" xlink:to="ifrs-full_ExpenseFromSharebasedPaymentTransactionsWithEmployees" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_EmployeeBenefitsExpense" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_EmployeeBenefitsExpense"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="StaffCostsComprisedAbstract" xlink:to="ifrs-full_EmployeeBenefitsExpense" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_NumberAndAverageNumberOfEmployeesAbstract" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NumberAndAverageNumberOfEmployeesAbstract"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfEmployeesAbstract" xlink:to="ifrs-full_NumberAndAverageNumberOfEmployeesAbstract" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ResearchAndDevelopment" xlink:href="tlsa-20221231.xsd#tlsa_ResearchAndDevelopment"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_NumberAndAverageNumberOfEmployeesAbstract" xlink:to="ResearchAndDevelopment" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="CorporateAndAdministration" xlink:href="tlsa-20221231.xsd#tlsa_CorporateAndAdministration"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_NumberAndAverageNumberOfEmployeesAbstract" xlink:to="CorporateAndAdministration" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="AverageMonthlyNumberOfEmployeesIncludingDirectorsEmployedByGroup" xlink:href="tlsa-20221231.xsd#tlsa_AverageMonthlyNumberOfEmployeesIncludingDirectorsEmployedByGroup"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_NumberAndAverageNumberOfEmployeesAbstract" xlink:to="AverageMonthlyNumberOfEmployeesIncludingDirectorsEmployedByGroup" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ScheduleofremunerationofkeymanagementpersonnelTable">
    <loc xlink:type="locator" xlink:label="ScheduleOfRemunerationOfKeyManagementPersonnelAbstract" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfRemunerationOfKeyManagementPersonnelAbstract"/>
    <loc xlink:type="locator" xlink:label="RemunerationofKeyManagementPersonnelDetailsScheduleofremunerationofkeymanagementpersonnelTable" xlink:href="tlsa-20221231.xsd#tlsa_RemunerationofKeyManagementPersonnelDetailsScheduleofremunerationofkeymanagementpersonnelTable"/>
    <loc xlink:type="locator" xlink:label="RemunerationofKeyManagementPersonnelDetailsScheduleofremunerationofkeymanagementpersonnelLineItems" xlink:href="tlsa-20221231.xsd#tlsa_RemunerationofKeyManagementPersonnelDetailsScheduleofremunerationofkeymanagementpersonnelLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfRemunerationOfKeyManagementPersonnelAbstract" xlink:to="RemunerationofKeyManagementPersonnelDetailsScheduleofremunerationofkeymanagementpersonnelTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CategoriesOfRelatedPartiesAxis"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RemunerationofKeyManagementPersonnelDetailsScheduleofremunerationofkeymanagementpersonnelTable" xlink:to="ifrs-full_CategoriesOfRelatedPartiesAxis" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_EntitysTotalForRelatedPartiesMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_EntitysTotalForRelatedPartiesMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:to="ifrs-full_EntitysTotalForRelatedPartiesMember" order="0.0"/>
    <loc xlink:type="locator" xlink:label="GCerroneMember" xlink:href="tlsa-20221231.xsd#tlsa_GCerroneMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:to="GCerroneMember" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="WSimonMember" xlink:href="tlsa-20221231.xsd#tlsa_WSimonMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:to="WSimonMember" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="GregorMacRaeMember" xlink:href="tlsa-20221231.xsd#tlsa_GregorMacRaeMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:to="GregorMacRaeMember" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="JBrancaccioMember" xlink:href="tlsa-20221231.xsd#tlsa_JBrancaccioMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:to="JBrancaccioMember" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="KShailubhaiMember" xlink:href="tlsa-20221231.xsd#tlsa_KShailubhaiMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:to="KShailubhaiMember" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="TAdamsMember" xlink:href="tlsa-20221231.xsd#tlsa_TAdamsMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:to="TAdamsMember" order="6.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RemunerationofKeyManagementPersonnelDetailsScheduleofremunerationofkeymanagementpersonnelTable" xlink:to="RemunerationofKeyManagementPersonnelDetailsScheduleofremunerationofkeymanagementpersonnelLineItems" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="DirectorsFees" xlink:href="tlsa-20221231.xsd#tlsa_DirectorsFees"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RemunerationofKeyManagementPersonnelDetailsScheduleofremunerationofkeymanagementpersonnelLineItems" xlink:to="DirectorsFees" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="Bonus" xlink:href="tlsa-20221231.xsd#tlsa_Bonus"/>
<!-- [WMV5][XcpuxYn59dz7vgYynUDuwG7r97K2jUTysl7vcz0lJt/tSeJz73kx1cLt0ZFF2SK/vxBCY0vdSrbxfU1oythJ56ec21DHGPZwpslDaKjyxv/SY+rtv6T6hI6VzbLHUXFHEKKqWRnqbRryxvSZpxP7JLAUo2nNrvGMEOXo1gwjeFHvMr8rDN8NoKFgUL58W/HcyTe+SyOR+7RVvmPyFcphWmTG3i4t9DpScKYI6Vh/t7JBYUuZ/BnLncVjPUFLCtpfme9U9oG8ty8ltmyXmbrgGgMcF55RwnTaB3tQpDfhGns=] CSR-->
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RemunerationofKeyManagementPersonnelDetailsScheduleofremunerationofkeymanagementpersonnelLineItems" xlink:to="Bonus" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="Salary" xlink:href="tlsa-20221231.xsd#tlsa_Salary"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RemunerationofKeyManagementPersonnelDetailsScheduleofremunerationofkeymanagementpersonnelLineItems" xlink:to="Salary" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ShareBasedPayments" xlink:href="tlsa-20221231.xsd#tlsa_ShareBasedPayments"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RemunerationofKeyManagementPersonnelDetailsScheduleofremunerationofkeymanagementpersonnelLineItems" xlink:to="ShareBasedPayments" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ScheduleofshareoptionsweregrantedtodirectorsTable">
    <loc xlink:type="locator" xlink:label="ScheduleOfShareOptionsWereGrantedToDirectorsAbstract" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfShareOptionsWereGrantedToDirectorsAbstract"/>
    <loc xlink:type="locator" xlink:label="RemunerationofKeyManagementPersonnelDetailsScheduleofshareoptionsweregrantedtodirectorsTable" xlink:href="tlsa-20221231.xsd#tlsa_RemunerationofKeyManagementPersonnelDetailsScheduleofshareoptionsweregrantedtodirectorsTable"/>
    <loc xlink:type="locator" xlink:label="RemunerationofKeyManagementPersonnelDetailsScheduleofshareoptionsweregrantedtodirectorsLineItems" xlink:href="tlsa-20221231.xsd#tlsa_RemunerationofKeyManagementPersonnelDetailsScheduleofshareoptionsweregrantedtodirectorsLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfShareOptionsWereGrantedToDirectorsAbstract" xlink:to="RemunerationofKeyManagementPersonnelDetailsScheduleofshareoptionsweregrantedtodirectorsTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CategoriesOfRelatedPartiesAxis"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RemunerationofKeyManagementPersonnelDetailsScheduleofshareoptionsweregrantedtodirectorsTable" xlink:to="ifrs-full_CategoriesOfRelatedPartiesAxis" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_EntitysTotalForRelatedPartiesMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_EntitysTotalForRelatedPartiesMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:to="ifrs-full_EntitysTotalForRelatedPartiesMember" order="0.0"/>
    <loc xlink:type="locator" xlink:label="GCerroneMember" xlink:href="tlsa-20221231.xsd#tlsa_GCerroneMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:to="GCerroneMember" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="KShailubhaiMember" xlink:href="tlsa-20221231.xsd#tlsa_KShailubhaiMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:to="KShailubhaiMember" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ZanbelettiMember" xlink:href="tlsa-20221231.xsd#tlsa_ZanbelettiMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:to="ZanbelettiMember" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="WSimonMember" xlink:href="tlsa-20221231.xsd#tlsa_WSimonMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:to="WSimonMember" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <loc xlink:type="locator" xlink:label="JBrancaccioMember" xlink:href="tlsa-20221231.xsd#tlsa_JBrancaccioMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:to="JBrancaccioMember" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <loc xlink:type="locator" xlink:label="TAdamsMember" xlink:href="tlsa-20221231.xsd#tlsa_TAdamsMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:to="TAdamsMember" order="6.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RemunerationofKeyManagementPersonnelDetailsScheduleofshareoptionsweregrantedtodirectorsTable" xlink:to="RemunerationofKeyManagementPersonnelDetailsScheduleofshareoptionsweregrantedtodirectorsLineItems" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="NumberOfShareOptionsWereGrantedToDirectors" xlink:href="tlsa-20221231.xsd#tlsa_NumberOfShareOptionsWereGrantedToDirectors"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RemunerationofKeyManagementPersonnelDetailsScheduleofshareoptionsweregrantedtodirectorsLineItems" xlink:to="NumberOfShareOptionsWereGrantedToDirectors" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ScheduleoffinancecostsTable">
    <loc xlink:type="locator" xlink:label="ScheduleOfFinanceCostsAbstract" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfFinanceCostsAbstract"/>
    <loc xlink:type="locator" xlink:label="GroupAbstract" xlink:href="tlsa-20221231.xsd#tlsa_GroupAbstract"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfFinanceCostsAbstract" xlink:to="GroupAbstract" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="FinanceIncomeReceivedOnNetInvestmentInLease" xlink:href="tlsa-20221231.xsd#tlsa_FinanceIncomeReceivedOnNetInvestmentInLease"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="GroupAbstract" xlink:to="FinanceIncomeReceivedOnNetInvestmentInLease" order="0.0" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_FinanceIncome" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FinanceIncome"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="GroupAbstract" xlink:to="ifrs-full_FinanceIncome" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <loc xlink:type="locator" xlink:label="FinanceChargeAccruedOnConvertibleLoanNotes" xlink:href="tlsa-20221231.xsd#tlsa_FinanceChargeAccruedOnConvertibleLoanNotes"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="GroupAbstract" xlink:to="FinanceChargeAccruedOnConvertibleLoanNotes" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_InterestExpenseOnLeaseLiabilities" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_InterestExpenseOnLeaseLiabilities"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="GroupAbstract" xlink:to="ifrs-full_InterestExpenseOnLeaseLiabilities" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="FinanceExpense" xlink:href="tlsa-20221231.xsd#tlsa_FinanceExpense"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfFinanceCostsAbstract" xlink:to="FinanceExpense" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <loc xlink:type="locator" xlink:label="NetFinanceExpenseRecognizedInStatementOfComprehensiveIncome" xlink:href="tlsa-20221231.xsd#tlsa_NetFinanceExpenseRecognizedInStatementOfComprehensiveIncome"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfFinanceCostsAbstract" xlink:to="NetFinanceExpenseRecognizedInStatementOfComprehensiveIncome" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ScheduleoftaxationTable">
    <loc xlink:type="locator" xlink:label="ScheduleOfTaxationAbstract" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfTaxationAbstract"/>
    <loc xlink:type="locator" xlink:label="GroupAbstract0" xlink:href="tlsa-20221231.xsd#tlsa_GroupAbstract0"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfTaxationAbstract" xlink:to="GroupAbstract0" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_CurrentTaxExpenseIncome" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentTaxExpenseIncome"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="GroupAbstract0" xlink:to="ifrs-full_CurrentTaxExpenseIncome" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="AdjustmentsDueToPriorPeriods" xlink:href="tlsa-20221231.xsd#tlsa_AdjustmentsDueToPriorPeriods"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="GroupAbstract0" xlink:to="AdjustmentsDueToPriorPeriods" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="IncomeTaxExpenseContinuingOperation" xlink:href="tlsa-20221231.xsd#tlsa_IncomeTaxExpenseContinuingOperation"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfTaxationAbstract" xlink:to="IncomeTaxExpenseContinuingOperation" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="OtherLossBeforeTaxation" xlink:href="tlsa-20221231.xsd#tlsa_OtherLossBeforeTaxation"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfTaxationAbstract" xlink:to="OtherLossBeforeTaxation" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="IncomeTaxReconciliationLossChargedAtStandardRateOfCorporationTax" xlink:href="tlsa-20221231.xsd#tlsa_IncomeTaxReconciliationLossChargedAtStandardRateOfCorporationTax"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfTaxationAbstract" xlink:to="IncomeTaxReconciliationLossChargedAtStandardRateOfCorporationTax" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="MovementInUnrecognisedDeferredTax" xlink:href="tlsa-20221231.xsd#tlsa_MovementInUnrecognisedDeferredTax"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfTaxationAbstract" xlink:to="MovementInUnrecognisedDeferredTax" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="IncomeTaxReconciliationExpensesNotDeductibleForTaxation" xlink:href="tlsa-20221231.xsd#tlsa_IncomeTaxReconciliationExpensesNotDeductibleForTaxation"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfTaxationAbstract" xlink:to="IncomeTaxReconciliationExpensesNotDeductibleForTaxation" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="AdjustmentsDueToPriorPeriods_0" xlink:href="tlsa-20221231.xsd#tlsa_AdjustmentsDueToPriorPeriods"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfTaxationAbstract" xlink:to="AdjustmentsDueToPriorPeriods_0" order="6.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="IncomeTaxReconciliationResearchAndDevelopmentClaim" xlink:href="tlsa-20221231.xsd#tlsa_IncomeTaxReconciliationResearchAndDevelopmentClaim"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfTaxationAbstract" xlink:to="IncomeTaxReconciliationResearchAndDevelopmentClaim" order="7.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="IncomeNotTaxableForTaxPurposes" xlink:href="tlsa-20221231.xsd#tlsa_IncomeNotTaxableForTaxPurposes"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfTaxationAbstract" xlink:to="IncomeNotTaxableForTaxPurposes" order="8.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_IncreaseDecreaseThroughForeignExchangeAndOtherMovementsFinancialAssets" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncreaseDecreaseThroughForeignExchangeAndOtherMovementsFinancialAssets"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfTaxationAbstract" xlink:to="ifrs-full_IncreaseDecreaseThroughForeignExchangeAndOtherMovementsFinancialAssets" order="9.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="AdjustmentsToBroughtForwardValues" xlink:href="tlsa-20221231.xsd#tlsa_AdjustmentsToBroughtForwardValues"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfTaxationAbstract" xlink:to="AdjustmentsToBroughtForwardValues" order="10.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ConsolidationAdjustmentInRelationToForeignExchangeMovements" xlink:href="tlsa-20221231.xsd#tlsa_ConsolidationAdjustmentInRelationToForeignExchangeMovements"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfTaxationAbstract" xlink:to="ConsolidationAdjustmentInRelationToForeignExchangeMovements" order="11.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_IncomeTaxExpenseContinuingOperations" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_IncomeTaxExpenseContinuingOperations"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfTaxationAbstract" xlink:to="ifrs-full_IncomeTaxExpenseContinuingOperations" order="12.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ScheduleoftaxationTable_Parentheticals">
    <loc xlink:type="locator" xlink:label="ScheduleOfTaxationAbstract" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfTaxationAbstract"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_TaxRateEffectOfTaxLosses" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TaxRateEffectOfTaxLosses"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfTaxationAbstract" xlink:to="ifrs-full_TaxRateEffectOfTaxLosses" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ScheduleofbasiclosspershareTable">
    <loc xlink:type="locator" xlink:label="ScheduleOfBasicLossPerShareAbstract" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfBasicLossPerShareAbstract"/>
    <loc xlink:type="locator" xlink:label="LossPerShareDetailsScheduleofbasiclosspershareTable" xlink:href="tlsa-20221231.xsd#tlsa_LossPerShareDetailsScheduleofbasiclosspershareTable"/>
    <loc xlink:type="locator" xlink:label="LossPerShareDetailsScheduleofbasiclosspershareLineItems" xlink:href="tlsa-20221231.xsd#tlsa_LossPerShareDetailsScheduleofbasiclosspershareLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfBasicLossPerShareAbstract" xlink:to="LossPerShareDetailsScheduleofbasiclosspershareTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_SegmentsAxis" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SegmentsAxis"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LossPerShareDetailsScheduleofbasiclosspershareTable" xlink:to="ifrs-full_SegmentsAxis" order="1.0"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_SegmentsMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SegmentsMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_SegmentsAxis" xlink:to="ifrs-full_SegmentsMember" order="0.0"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LossPerShareDetailsScheduleofbasiclosspershareTable" xlink:to="LossPerShareDetailsScheduleofbasiclosspershareLineItems" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ProfitLoss" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ProfitLoss"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LossPerShareDetailsScheduleofbasiclosspershareLineItems" xlink:to="ifrs-full_ProfitLoss" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_WeightedAverageShares" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_WeightedAverageShares"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LossPerShareDetailsScheduleofbasiclosspershareLineItems" xlink:to="ifrs-full_WeightedAverageShares" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="BasicLossPerSharecentsPerShare" xlink:href="tlsa-20221231.xsd#tlsa_BasicLossPerSharecentsPerShare"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LossPerShareDetailsScheduleofbasiclosspershareLineItems" xlink:to="BasicLossPerSharecentsPerShare" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ScheduleofotherreceivablesTable">
    <loc xlink:type="locator" xlink:label="ScheduleOfOtherReceivablesAbstract" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfOtherReceivablesAbstract"/>
    <loc xlink:type="locator" xlink:label="OtherReceivablesDetailsScheduleofotherreceivablesTable" xlink:href="tlsa-20221231.xsd#tlsa_OtherReceivablesDetailsScheduleofotherreceivablesTable"/>
    <loc xlink:type="locator" xlink:label="OtherReceivablesDetailsScheduleofotherreceivablesLineItems" xlink:href="tlsa-20221231.xsd#tlsa_OtherReceivablesDetailsScheduleofotherreceivablesLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfOtherReceivablesAbstract" xlink:to="OtherReceivablesDetailsScheduleofotherreceivablesTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_SegmentsAxis" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SegmentsAxis"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OtherReceivablesDetailsScheduleofotherreceivablesTable" xlink:to="ifrs-full_SegmentsAxis" order="1.0"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_SegmentsMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SegmentsMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_SegmentsAxis" xlink:to="ifrs-full_SegmentsMember" order="0.0"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OtherReceivablesDetailsScheduleofotherreceivablesTable" xlink:to="OtherReceivablesDetailsScheduleofotherreceivablesLineItems" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ValueAddedTaxReceivables" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ValueAddedTaxReceivables"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OtherReceivablesDetailsScheduleofotherreceivablesLineItems" xlink:to="ifrs-full_ValueAddedTaxReceivables" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="SecurityDepositsReceivable" xlink:href="tlsa-20221231.xsd#tlsa_SecurityDepositsReceivable"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OtherReceivablesDetailsScheduleofotherreceivablesLineItems" xlink:to="SecurityDepositsReceivable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_Prepayments" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_Prepayments"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OtherReceivablesDetailsScheduleofotherreceivablesLineItems" xlink:to="ifrs-full_Prepayments" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_TradeAndOtherReceivables" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TradeAndOtherReceivables"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OtherReceivablesDetailsScheduleofotherreceivablesLineItems" xlink:to="ifrs-full_TradeAndOtherReceivables" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ScheduleofsharecapitalarisingontheshareforshareexchangeTable">
    <loc xlink:type="locator" xlink:label="ScheduleOfShareCapitalArisingOnTheShareForShareExchangeAbstract" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfShareCapitalArisingOnTheShareForShareExchangeAbstract"/>
    <loc xlink:type="locator" xlink:label="ShareCapitalandSharePremiumDetailsScheduleofsharecapitalarisingontheshareforshareexchangeTable" xlink:href="tlsa-20221231.xsd#tlsa_ShareCapitalandSharePremiumDetailsScheduleofsharecapitalarisingontheshareforshareexchangeTable"/>
    <loc xlink:type="locator" xlink:label="ShareCapitalandSharePremiumDetailsScheduleofsharecapitalarisingontheshareforshareexchangeLineItems" xlink:href="tlsa-20221231.xsd#tlsa_ShareCapitalandSharePremiumDetailsScheduleofsharecapitalarisingontheshareforshareexchangeLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfShareCapitalArisingOnTheShareForShareExchangeAbstract" xlink:to="ShareCapitalandSharePremiumDetailsScheduleofsharecapitalarisingontheshareforshareexchangeTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_SegmentsAxis" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SegmentsAxis"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareCapitalandSharePremiumDetailsScheduleofsharecapitalarisingontheshareforshareexchangeTable" xlink:to="ifrs-full_SegmentsAxis" order="1.0"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_SegmentsMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SegmentsMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_SegmentsAxis" xlink:to="ifrs-full_SegmentsMember" order="0.0"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareCapitalandSharePremiumDetailsScheduleofsharecapitalarisingontheshareforshareexchangeTable" xlink:to="ShareCapitalandSharePremiumDetailsScheduleofsharecapitalarisingontheshareforshareexchangeLineItems" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="NominalValueAnnualReport" xlink:href="tlsa-20221231.xsd#tlsa_NominalValueAnnualReport"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareCapitalandSharePremiumDetailsScheduleofsharecapitalarisingontheshareforshareexchangeLineItems" xlink:to="NominalValueAnnualReport" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ShareCapitalSharesAnnualReport" xlink:href="tlsa-20221231.xsd#tlsa_ShareCapitalSharesAnnualReport"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareCapitalandSharePremiumDetailsScheduleofsharecapitalarisingontheshareforshareexchangeLineItems" xlink:to="ShareCapitalSharesAnnualReport" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ShareCapitalValueAnnualReport" xlink:href="tlsa-20221231.xsd#tlsa_ShareCapitalValueAnnualReport"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareCapitalandSharePremiumDetailsScheduleofsharecapitalarisingontheshareforshareexchangeLineItems" xlink:to="ShareCapitalValueAnnualReport" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="SharePremiumAnnualReport" xlink:href="tlsa-20221231.xsd#tlsa_SharePremiumAnnualReport"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareCapitalandSharePremiumDetailsScheduleofsharecapitalarisingontheshareforshareexchangeLineItems" xlink:to="SharePremiumAnnualReport" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="MergerReserveAtJanuary12021Per20FAnnualReport" xlink:href="tlsa-20221231.xsd#tlsa_MergerReserveAtJanuary12021Per20FAnnualReport"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareCapitalandSharePremiumDetailsScheduleofsharecapitalarisingontheshareforshareexchangeLineItems" xlink:to="MergerReserveAtJanuary12021Per20FAnnualReport" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="GroupReorganizationAbstract" xlink:href="tlsa-20221231.xsd#tlsa_GroupReorganizationAbstract"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareCapitalandSharePremiumDetailsScheduleofsharecapitalarisingontheshareforshareexchangeLineItems" xlink:to="GroupReorganizationAbstract" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="NominalValueEliminationOfShareCapital" xlink:href="tlsa-20221231.xsd#tlsa_NominalValueEliminationOfShareCapital"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="GroupReorganizationAbstract" xlink:to="NominalValueEliminationOfShareCapital" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ShareCapitalSharesEliminationOfShare" xlink:href="tlsa-20221231.xsd#tlsa_ShareCapitalSharesEliminationOfShare"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="GroupReorganizationAbstract" xlink:to="ShareCapitalSharesEliminationOfShare" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ShareCapitalValueEliminationOfShareCapital" xlink:href="tlsa-20221231.xsd#tlsa_ShareCapitalValueEliminationOfShareCapital"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="GroupReorganizationAbstract" xlink:to="ShareCapitalValueEliminationOfShareCapital" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="SharePremiumEliminationOfShareCapitalIn" xlink:href="tlsa-20221231.xsd#tlsa_SharePremiumEliminationOfShareCapitalIn"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="GroupReorganizationAbstract" xlink:to="SharePremiumEliminationOfShareCapitalIn" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="MergerReserveEliminationOfShareCapitalIn" xlink:href="tlsa-20221231.xsd#tlsa_MergerReserveEliminationOfShareCapitalIn"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="GroupReorganizationAbstract" xlink:to="MergerReserveEliminationOfShareCapitalIn" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="NominalValueSharesIssuedPursuantToShareForShareExchangeAndConsolidation" xlink:href="tlsa-20221231.xsd#tlsa_NominalValueSharesIssuedPursuantToShareForShareExchangeAndConsolidation"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="GroupReorganizationAbstract" xlink:to="NominalValueSharesIssuedPursuantToShareForShareExchangeAndConsolidation" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ShareCapitalSharesSharesIssuedPursuantForShareExchangeAndConsolidation" xlink:href="tlsa-20221231.xsd#tlsa_ShareCapitalSharesSharesIssuedPursuantForShareExchangeAndConsolidation"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="GroupReorganizationAbstract" xlink:to="ShareCapitalSharesSharesIssuedPursuantForShareExchangeAndConsolidation" order="6.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ShareCapitalValueSharesIssuedPursuantToShareExchangeAndConsolidation" xlink:href="tlsa-20221231.xsd#tlsa_ShareCapitalValueSharesIssuedPursuantToShareExchangeAndConsolidation"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="GroupReorganizationAbstract" xlink:to="ShareCapitalValueSharesIssuedPursuantToShareExchangeAndConsolidation" order="7.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="SharePremiumSharesIssuedPursuantToShareForShareExchangeAndConsolidation" xlink:href="tlsa-20221231.xsd#tlsa_SharePremiumSharesIssuedPursuantToShareForShareExchangeAndConsolidation"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="GroupReorganizationAbstract" xlink:to="SharePremiumSharesIssuedPursuantToShareForShareExchangeAndConsolidation" order="8.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="MergerReserveSharesIssuedPursuantToShareForShareExchangeAndConsolidation" xlink:href="tlsa-20221231.xsd#tlsa_MergerReserveSharesIssuedPursuantToShareForShareExchangeAndConsolidation"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="GroupReorganizationAbstract" xlink:to="MergerReserveSharesIssuedPursuantToShareForShareExchangeAndConsolidation" order="9.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="EliminationOfOtherReserves" xlink:href="tlsa-20221231.xsd#tlsa_EliminationOfOtherReserves"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="GroupReorganizationAbstract" xlink:to="EliminationOfOtherReserves" order="10.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="NominalValueRestated" xlink:href="tlsa-20221231.xsd#tlsa_NominalValueRestated"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareCapitalandSharePremiumDetailsScheduleofsharecapitalarisingontheshareforshareexchangeLineItems" xlink:to="NominalValueRestated" order="6.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ShareCapitalSharesRestated" xlink:href="tlsa-20221231.xsd#tlsa_ShareCapitalSharesRestated"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareCapitalandSharePremiumDetailsScheduleofsharecapitalarisingontheshareforshareexchangeLineItems" xlink:to="ShareCapitalSharesRestated" order="7.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ShareCapitalValueRestated" xlink:href="tlsa-20221231.xsd#tlsa_ShareCapitalValueRestated"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareCapitalandSharePremiumDetailsScheduleofsharecapitalarisingontheshareforshareexchangeLineItems" xlink:to="ShareCapitalValueRestated" order="8.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="SharePremiumRestatedAt1January2021" xlink:href="tlsa-20221231.xsd#tlsa_SharePremiumRestatedAt1January2021"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareCapitalandSharePremiumDetailsScheduleofsharecapitalarisingontheshareforshareexchangeLineItems" xlink:to="SharePremiumRestatedAt1January2021" order="9.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="MergerReserveRestated" xlink:href="tlsa-20221231.xsd#tlsa_MergerReserveRestated"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareCapitalandSharePremiumDetailsScheduleofsharecapitalarisingontheshareforshareexchangeLineItems" xlink:to="MergerReserveRestated" order="10.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="NominalValueConversionOfWarrants" xlink:href="tlsa-20221231.xsd#tlsa_NominalValueConversionOfWarrants"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="MergerReserveRestated" xlink:to="NominalValueConversionOfWarrants" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ShareCapitalSharesConversionOfWarrants" xlink:href="tlsa-20221231.xsd#tlsa_ShareCapitalSharesConversionOfWarrants"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="MergerReserveRestated" xlink:to="ShareCapitalSharesConversionOfWarrants" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ShareCapitalConversionOfWarrants" xlink:href="tlsa-20221231.xsd#tlsa_ShareCapitalConversionOfWarrants"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="MergerReserveRestated" xlink:to="ShareCapitalConversionOfWarrants" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="SharePremiumConversionOfWarrants" xlink:href="tlsa-20221231.xsd#tlsa_SharePremiumConversionOfWarrants"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="MergerReserveRestated" xlink:to="SharePremiumConversionOfWarrants" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="MergerReserveConversionOfWarrants" xlink:href="tlsa-20221231.xsd#tlsa_MergerReserveConversionOfWarrants"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="MergerReserveRestated" xlink:to="MergerReserveConversionOfWarrants" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="NominalValueConversionOfLoan" xlink:href="tlsa-20221231.xsd#tlsa_NominalValueConversionOfLoan"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="MergerReserveRestated" xlink:to="NominalValueConversionOfLoan" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ShareCapitalSharesConversionOfLoan" xlink:href="tlsa-20221231.xsd#tlsa_ShareCapitalSharesConversionOfLoan"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="MergerReserveRestated" xlink:to="ShareCapitalSharesConversionOfLoan" order="6.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ShareCapitalValueConversionOfLoan" xlink:href="tlsa-20221231.xsd#tlsa_ShareCapitalValueConversionOfLoan"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="MergerReserveRestated" xlink:to="ShareCapitalValueConversionOfLoan" order="7.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="SharePremiumConversionOfLoan" xlink:href="tlsa-20221231.xsd#tlsa_SharePremiumConversionOfLoan"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="MergerReserveRestated" xlink:to="SharePremiumConversionOfLoan" order="8.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="MergerReserveConversionOfLoan" xlink:href="tlsa-20221231.xsd#tlsa_MergerReserveConversionOfLoan"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="MergerReserveRestated" xlink:to="MergerReserveConversionOfLoan" order="9.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="NominalValueIssuedInLieuOfCashBonus" xlink:href="tlsa-20221231.xsd#tlsa_NominalValueIssuedInLieuOfCashBonus"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="MergerReserveRestated" xlink:to="NominalValueIssuedInLieuOfCashBonus" order="10.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ShareCapitalSharesIssuedInLieuOfCashBonus" xlink:href="tlsa-20221231.xsd#tlsa_ShareCapitalSharesIssuedInLieuOfCashBonus"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="MergerReserveRestated" xlink:to="ShareCapitalSharesIssuedInLieuOfCashBonus" order="11.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ShareCapitalValueIssuedInCashBonus" xlink:href="tlsa-20221231.xsd#tlsa_ShareCapitalValueIssuedInCashBonus"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="MergerReserveRestated" xlink:to="ShareCapitalValueIssuedInCashBonus" order="12.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="SharePremiumIssuedInCashBonus" xlink:href="tlsa-20221231.xsd#tlsa_SharePremiumIssuedInCashBonus"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="MergerReserveRestated" xlink:to="SharePremiumIssuedInCashBonus" order="13.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="MergerReserveIssuedInLieuOfCashBonus" xlink:href="tlsa-20221231.xsd#tlsa_MergerReserveIssuedInLieuOfCashBonus"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="MergerReserveRestated" xlink:to="MergerReserveIssuedInLieuOfCashBonus" order="14.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ShareCapitalShares" xlink:href="tlsa-20221231.xsd#tlsa_ShareCapitalShares"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareCapitalandSharePremiumDetailsScheduleofsharecapitalarisingontheshareforshareexchangeLineItems" xlink:to="ShareCapitalShares" order="11.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ShareCapitalValueAt31December2021" xlink:href="tlsa-20221231.xsd#tlsa_ShareCapitalValueAt31December2021"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareCapitalandSharePremiumDetailsScheduleofsharecapitalarisingontheshareforshareexchangeLineItems" xlink:to="ShareCapitalValueAt31December2021" order="12.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="SharePremiumEnding" xlink:href="tlsa-20221231.xsd#tlsa_SharePremiumEnding"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareCapitalandSharePremiumDetailsScheduleofsharecapitalarisingontheshareforshareexchangeLineItems" xlink:to="SharePremiumEnding" order="13.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="MergerReserveEnding" xlink:href="tlsa-20221231.xsd#tlsa_MergerReserveEnding"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareCapitalandSharePremiumDetailsScheduleofsharecapitalarisingontheshareforshareexchangeLineItems" xlink:to="MergerReserveEnding" order="14.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ScheduleofshareoptionplanTable">
    <loc xlink:type="locator" xlink:label="ScheduleOfShareOptionPlanAbstract" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfShareOptionPlanAbstract"/>
    <loc xlink:type="locator" xlink:label="WeightedAverageExercisePriceOutstanding" xlink:href="tlsa-20221231.xsd#tlsa_WeightedAverageExercisePriceOutstanding"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfShareOptionPlanAbstract" xlink:to="WeightedAverageExercisePriceOutstanding" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <loc xlink:type="locator" xlink:label="OptionsOutstanding" xlink:href="tlsa-20221231.xsd#tlsa_OptionsOutstanding"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfShareOptionPlanAbstract" xlink:to="OptionsOutstanding" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <loc xlink:type="locator" xlink:label="WeightedAverageExercisePriceGranted" xlink:href="tlsa-20221231.xsd#tlsa_WeightedAverageExercisePriceGranted"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfShareOptionPlanAbstract" xlink:to="WeightedAverageExercisePriceGranted" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="OptionsGranted" xlink:href="tlsa-20221231.xsd#tlsa_OptionsGranted"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfShareOptionPlanAbstract" xlink:to="OptionsGranted" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="WeightedAverageExercisePriceForfeitedCancelled" xlink:href="tlsa-20221231.xsd#tlsa_WeightedAverageExercisePriceForfeitedCancelled"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfShareOptionPlanAbstract" xlink:to="WeightedAverageExercisePriceForfeitedCancelled" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="OptionsForfeitedCancelled" xlink:href="tlsa-20221231.xsd#tlsa_OptionsForfeitedCancelled"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfShareOptionPlanAbstract" xlink:to="OptionsForfeitedCancelled" order="5.0" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <loc xlink:type="locator" xlink:label="WeightedAverageExercisePriceExercised" xlink:href="tlsa-20221231.xsd#tlsa_WeightedAverageExercisePriceExercised"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfShareOptionPlanAbstract" xlink:to="WeightedAverageExercisePriceExercised" order="6.0" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <loc xlink:type="locator" xlink:label="OptionsExercised" xlink:href="tlsa-20221231.xsd#tlsa_OptionsExercised"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfShareOptionPlanAbstract" xlink:to="OptionsExercised" order="7.0" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <loc xlink:type="locator" xlink:label="WeightedAverageExercisePriceOutstanding_0" xlink:href="tlsa-20221231.xsd#tlsa_WeightedAverageExercisePriceOutstanding"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfShareOptionPlanAbstract" xlink:to="WeightedAverageExercisePriceOutstanding_0" order="8.0" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <loc xlink:type="locator" xlink:label="OptionsOutstanding_0" xlink:href="tlsa-20221231.xsd#tlsa_OptionsOutstanding"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfShareOptionPlanAbstract" xlink:to="OptionsOutstanding_0" order="9.0" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <loc xlink:type="locator" xlink:label="WeightedAverageExercisePriceExercisable" xlink:href="tlsa-20221231.xsd#tlsa_WeightedAverageExercisePriceExercisable"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfShareOptionPlanAbstract" xlink:to="WeightedAverageExercisePriceExercisable" order="10.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="OptionsExercisable" xlink:href="tlsa-20221231.xsd#tlsa_OptionsExercisable"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfShareOptionPlanAbstract" xlink:to="OptionsExercisable" order="11.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ScheduleofshareoptionsexpirydatesandexercisepriceTable">
    <loc xlink:type="locator" xlink:label="ScheduleOfShareOptionsExpiryDatesAndExercisePriceAbstract" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfShareOptionsExpiryDatesAndExercisePriceAbstract"/>
    <loc xlink:type="locator" xlink:label="ShareBasedPaymentsDetailsScheduleofshareoptionsexpirydatesandexercisepriceTable" xlink:href="tlsa-20221231.xsd#tlsa_ShareBasedPaymentsDetailsScheduleofshareoptionsexpirydatesandexercisepriceTable"/>
    <loc xlink:type="locator" xlink:label="ShareBasedPaymentsDetailsScheduleofshareoptionsexpirydatesandexercisepriceLineItems" xlink:href="tlsa-20221231.xsd#tlsa_ShareBasedPaymentsDetailsScheduleofshareoptionsexpirydatesandexercisepriceLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfShareOptionsExpiryDatesAndExercisePriceAbstract" xlink:to="ShareBasedPaymentsDetailsScheduleofshareoptionsexpirydatesandexercisepriceTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_TypesOfSharebasedPaymentArrangementsAxis" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TypesOfSharebasedPaymentArrangementsAxis"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareBasedPaymentsDetailsScheduleofshareoptionsexpirydatesandexercisepriceTable" xlink:to="ifrs-full_TypesOfSharebasedPaymentArrangementsAxis" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_SharebasedPaymentArrangementsMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SharebasedPaymentArrangementsMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_TypesOfSharebasedPaymentArrangementsAxis" xlink:to="ifrs-full_SharebasedPaymentArrangementsMember" order="0.0"/>
    <loc xlink:type="locator" xlink:label="ExercisePriceOneMember" xlink:href="tlsa-20221231.xsd#tlsa_ExercisePriceOneMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_TypesOfSharebasedPaymentArrangementsAxis" xlink:to="ExercisePriceOneMember" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ExercisePriceTwoMember" xlink:href="tlsa-20221231.xsd#tlsa_ExercisePriceTwoMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_TypesOfSharebasedPaymentArrangementsAxis" xlink:to="ExercisePriceTwoMember" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ExercisePriceThreeMember" xlink:href="tlsa-20221231.xsd#tlsa_ExercisePriceThreeMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_TypesOfSharebasedPaymentArrangementsAxis" xlink:to="ExercisePriceThreeMember" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ExercisePriceFourMember" xlink:href="tlsa-20221231.xsd#tlsa_ExercisePriceFourMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_TypesOfSharebasedPaymentArrangementsAxis" xlink:to="ExercisePriceFourMember" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ExercisePriceSevenMember" xlink:href="tlsa-20221231.xsd#tlsa_ExercisePriceSevenMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_TypesOfSharebasedPaymentArrangementsAxis" xlink:to="ExercisePriceSevenMember" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ShareOptionsMember" xlink:href="tlsa-20221231.xsd#tlsa_ShareOptionsMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_TypesOfSharebasedPaymentArrangementsAxis" xlink:to="ShareOptionsMember" order="6.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ExercisePriceEightMember" xlink:href="tlsa-20221231.xsd#tlsa_ExercisePriceEightMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_TypesOfSharebasedPaymentArrangementsAxis" xlink:to="ExercisePriceEightMember" order="7.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ExercisePriceNineMember" xlink:href="tlsa-20221231.xsd#tlsa_ExercisePriceNineMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_TypesOfSharebasedPaymentArrangementsAxis" xlink:to="ExercisePriceNineMember" order="8.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareBasedPaymentsDetailsScheduleofshareoptionsexpirydatesandexercisepriceTable" xlink:to="ShareBasedPaymentsDetailsScheduleofshareoptionsexpirydatesandexercisepriceLineItems" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="GrantDate" xlink:href="tlsa-20221231.xsd#tlsa_GrantDate"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareBasedPaymentsDetailsScheduleofshareoptionsexpirydatesandexercisepriceLineItems" xlink:to="GrantDate" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ExpiryDate" xlink:href="tlsa-20221231.xsd#tlsa_ExpiryDate"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareBasedPaymentsDetailsScheduleofshareoptionsexpirydatesandexercisepriceLineItems" xlink:to="ExpiryDate" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ShareOptionsExercisePrice" xlink:href="tlsa-20221231.xsd#tlsa_ShareOptionsExercisePrice"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareBasedPaymentsDetailsScheduleofshareoptionsexpirydatesandexercisepriceLineItems" xlink:to="ShareOptionsExercisePrice" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ScheduleofmodelinputsforoptionsgrantedundertheblackscholesvaluationmodelTable">
    <loc xlink:type="locator" xlink:label="ScheduleOfModelInputsForOptionsGrantedUnderTheBlackScholesValuationModelAbstract" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfModelInputsForOptionsGrantedUnderTheBlackScholesValuationModelAbstract"/>
    <loc xlink:type="locator" xlink:label="ShareBasedPaymentsDetailsScheduleofmodelinputsforoptionsgrantedundertheblackscholesvaluationmodelTable" xlink:href="tlsa-20221231.xsd#tlsa_ShareBasedPaymentsDetailsScheduleofmodelinputsforoptionsgrantedundertheblackscholesvaluationmodelTable"/>
    <loc xlink:type="locator" xlink:label="ShareBasedPaymentsDetailsScheduleofmodelinputsforoptionsgrantedundertheblackscholesvaluationmodelLineItems" xlink:href="tlsa-20221231.xsd#tlsa_ShareBasedPaymentsDetailsScheduleofmodelinputsforoptionsgrantedundertheblackscholesvaluationmodelLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfModelInputsForOptionsGrantedUnderTheBlackScholesValuationModelAbstract" xlink:to="ShareBasedPaymentsDetailsScheduleofmodelinputsforoptionsgrantedundertheblackscholesvaluationmodelTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_RangeAxis" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_RangeAxis"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareBasedPaymentsDetailsScheduleofmodelinputsforoptionsgrantedundertheblackscholesvaluationmodelTable" xlink:to="ifrs-full_RangeAxis" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_RangesMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_RangesMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_RangeAxis" xlink:to="ifrs-full_RangesMember" order="0.0"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_BottomOfRangeMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_BottomOfRangeMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_RangeAxis" xlink:to="ifrs-full_BottomOfRangeMember" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_TopOfRangeMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TopOfRangeMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_RangeAxis" xlink:to="ifrs-full_TopOfRangeMember" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareBasedPaymentsDetailsScheduleofmodelinputsforoptionsgrantedundertheblackscholesvaluationmodelTable" xlink:to="ShareBasedPaymentsDetailsScheduleofmodelinputsforoptionsgrantedundertheblackscholesvaluationmodelLineItems" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="GrantDateSharesPrice" xlink:href="tlsa-20221231.xsd#tlsa_GrantDateSharesPrice"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareBasedPaymentsDetailsScheduleofmodelinputsforoptionsgrantedundertheblackscholesvaluationmodelLineItems" xlink:to="GrantDateSharesPrice" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ExerciseSharePrice" xlink:href="tlsa-20221231.xsd#tlsa_ExerciseSharePrice"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareBasedPaymentsDetailsScheduleofmodelinputsforoptionsgrantedundertheblackscholesvaluationmodelLineItems" xlink:to="ExerciseSharePrice" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DescriptionOfRiskFreeInterestRateShareOptionsGranted" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfRiskFreeInterestRateShareOptionsGranted"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareBasedPaymentsDetailsScheduleofmodelinputsforoptionsgrantedundertheblackscholesvaluationmodelLineItems" xlink:to="ifrs-full_DescriptionOfRiskFreeInterestRateShareOptionsGranted" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DescriptionOfExpectedVolatilityShareOptionsGranted" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DescriptionOfExpectedVolatilityShareOptionsGranted"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareBasedPaymentsDetailsScheduleofmodelinputsforoptionsgrantedundertheblackscholesvaluationmodelLineItems" xlink:to="ifrs-full_DescriptionOfExpectedVolatilityShareOptionsGranted" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="OptionLifeShareOptionsGranted" xlink:href="tlsa-20221231.xsd#tlsa_OptionLifeShareOptionsGranted"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareBasedPaymentsDetailsScheduleofmodelinputsforoptionsgrantedundertheblackscholesvaluationmodelLineItems" xlink:to="OptionLifeShareOptionsGranted" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_WeightedAverageSharePrice2019" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_WeightedAverageSharePrice2019"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareBasedPaymentsDetailsScheduleofmodelinputsforoptionsgrantedundertheblackscholesvaluationmodelLineItems" xlink:to="ifrs-full_WeightedAverageSharePrice2019" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_WeightedAverageSharePriceShareOptionsGranted2019" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_WeightedAverageSharePriceShareOptionsGranted2019"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareBasedPaymentsDetailsScheduleofmodelinputsforoptionsgrantedundertheblackscholesvaluationmodelLineItems" xlink:to="ifrs-full_WeightedAverageSharePriceShareOptionsGranted2019" order="6.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ScheduleofequityincentiveplanTable">
    <loc xlink:type="locator" xlink:label="ScheduleOfEquityIncentivePlanAbstract" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfEquityIncentivePlanAbstract"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_WeightedAverageExercisePriceOfShareOptionsOutstandingInSharebasedPaymentArrangement2019" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_WeightedAverageExercisePriceOfShareOptionsOutstandingInSharebasedPaymentArrangement2019"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfEquityIncentivePlanAbstract" xlink:to="ifrs-full_WeightedAverageExercisePriceOfShareOptionsOutstandingInSharebasedPaymentArrangement2019" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <loc xlink:type="locator" xlink:label="NumberOfShareOptionsOutstanding" xlink:href="tlsa-20221231.xsd#tlsa_NumberOfShareOptionsOutstanding"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfEquityIncentivePlanAbstract" xlink:to="NumberOfShareOptionsOutstanding" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_WeightedAverageExercisePriceOfShareOptionsGrantedInSharebasedPaymentArrangement2019" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_WeightedAverageExercisePriceOfShareOptionsGrantedInSharebasedPaymentArrangement2019"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfEquityIncentivePlanAbstract" xlink:to="ifrs-full_WeightedAverageExercisePriceOfShareOptionsGrantedInSharebasedPaymentArrangement2019" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="NumberOfShareOptionsGranted" xlink:href="tlsa-20221231.xsd#tlsa_NumberOfShareOptionsGranted"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfEquityIncentivePlanAbstract" xlink:to="NumberOfShareOptionsGranted" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_WeightedAverageExercisePriceOfShareOptionsForfeitedInSharebasedPaymentArrangement2019" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_WeightedAverageExercisePriceOfShareOptionsForfeitedInSharebasedPaymentArrangement2019"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfEquityIncentivePlanAbstract" xlink:to="ifrs-full_WeightedAverageExercisePriceOfShareOptionsForfeitedInSharebasedPaymentArrangement2019" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="NumberOfShareOptionsForfeited" xlink:href="tlsa-20221231.xsd#tlsa_NumberOfShareOptionsForfeited"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfEquityIncentivePlanAbstract" xlink:to="NumberOfShareOptionsForfeited" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_WeightedAverageExercisePriceOfShareOptionsExercisedInSharebasedPaymentArrangement2019" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_WeightedAverageExercisePriceOfShareOptionsExercisedInSharebasedPaymentArrangement2019"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfEquityIncentivePlanAbstract" xlink:to="ifrs-full_WeightedAverageExercisePriceOfShareOptionsExercisedInSharebasedPaymentArrangement2019" order="6.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="NumberofOptionsExercised" xlink:href="tlsa-20221231.xsd#tlsa_NumberofOptionsExercised"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfEquityIncentivePlanAbstract" xlink:to="NumberofOptionsExercised" order="7.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_WeightedAverageExercisePriceOfShareOptionsOutstandingInSharebasedPaymentArrangement2019_0" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_WeightedAverageExercisePriceOfShareOptionsOutstandingInSharebasedPaymentArrangement2019"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfEquityIncentivePlanAbstract" xlink:to="ifrs-full_WeightedAverageExercisePriceOfShareOptionsOutstandingInSharebasedPaymentArrangement2019_0" order="8.0" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <loc xlink:type="locator" xlink:label="NumberOfShareOptionsOutstanding_0" xlink:href="tlsa-20221231.xsd#tlsa_NumberOfShareOptionsOutstanding"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfEquityIncentivePlanAbstract" xlink:to="NumberOfShareOptionsOutstanding_0" order="9.0" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_WeightedAverageExercisePriceOfShareOptionsExercisableInSharebasedPaymentArrangement2019" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_WeightedAverageExercisePriceOfShareOptionsExercisableInSharebasedPaymentArrangement2019"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfEquityIncentivePlanAbstract" xlink:to="ifrs-full_WeightedAverageExercisePriceOfShareOptionsExercisableInSharebasedPaymentArrangement2019" order="10.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="NumberOfShareOptionsExercisable" xlink:href="tlsa-20221231.xsd#tlsa_NumberOfShareOptionsExercisable"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfEquityIncentivePlanAbstract" xlink:to="NumberOfShareOptionsExercisable" order="11.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ScheduleofestimatedthefairvalueofwarrantsusingTable">
    <loc xlink:type="locator" xlink:label="ScheduleOfEstimatedTheFairValueOfWarrantsUsingAbstract" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfEstimatedTheFairValueOfWarrantsUsingAbstract"/>
    <loc xlink:type="locator" xlink:label="FairValueOutstanding" xlink:href="tlsa-20221231.xsd#tlsa_FairValueOutstanding"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfEstimatedTheFairValueOfWarrantsUsingAbstract" xlink:to="FairValueOutstanding" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <loc xlink:type="locator" xlink:label="Granted" xlink:href="tlsa-20221231.xsd#tlsa_Granted"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfEstimatedTheFairValueOfWarrantsUsingAbstract" xlink:to="Granted" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_AdjustmentsForSharebasedPayments" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForSharebasedPayments"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfEstimatedTheFairValueOfWarrantsUsingAbstract" xlink:to="ifrs-full_AdjustmentsForSharebasedPayments" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="FairValueOutstanding_0" xlink:href="tlsa-20221231.xsd#tlsa_FairValueOutstanding"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfEstimatedTheFairValueOfWarrantsUsingAbstract" xlink:to="FairValueOutstanding_0" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ScheduleoffinancialliabilitiesbasedoncontractualundiscountedpaymentsTable">
    <loc xlink:type="locator" xlink:label="ScheduleOfFinancialLiabilitiesBasedOnContractualUndiscountedPaymentsAbstract" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfFinancialLiabilitiesBasedOnContractualUndiscountedPaymentsAbstract"/>
    <loc xlink:type="locator" xlink:label="FinancialInstrumentsDetailsScheduleoffinancialliabilitiesbasedoncontractualundiscountedpaymentsTable" xlink:href="tlsa-20221231.xsd#tlsa_FinancialInstrumentsDetailsScheduleoffinancialliabilitiesbasedoncontractualundiscountedpaymentsTable"/>
    <loc xlink:type="locator" xlink:label="FinancialInstrumentsDetailsScheduleoffinancialliabilitiesbasedoncontractualundiscountedpaymentsLineItems" xlink:href="tlsa-20221231.xsd#tlsa_FinancialInstrumentsDetailsScheduleoffinancialliabilitiesbasedoncontractualundiscountedpaymentsLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfFinancialLiabilitiesBasedOnContractualUndiscountedPaymentsAbstract" xlink:to="FinancialInstrumentsDetailsScheduleoffinancialliabilitiesbasedoncontractualundiscountedpaymentsTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_FinancialInstrumentsMeasuredAtFairValueThroughProfitOrLossBecauseCreditDerivativeIsUsedToManageCreditRiskAxis" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FinancialInstrumentsMeasuredAtFairValueThroughProfitOrLossBecauseCreditDerivativeIsUsedToManageCreditRiskAxis"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="FinancialInstrumentsDetailsScheduleoffinancialliabilitiesbasedoncontractualundiscountedpaymentsTable" xlink:to="ifrs-full_FinancialInstrumentsMeasuredAtFairValueThroughProfitOrLossBecauseCreditDerivativeIsUsedToManageCreditRiskAxis" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_FinancialInstrumentsMeasuredAtFairValueThroughProfitOrLossBecauseCreditDerivativeIsUsedToManageCreditRiskMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_FinancialInstrumentsMeasuredAtFairValueThroughProfitOrLossBecauseCreditDerivativeIsUsedToManageCreditRiskMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_FinancialInstrumentsMeasuredAtFairValueThroughProfitOrLossBecauseCreditDerivativeIsUsedToManageCreditRiskAxis" xlink:to="ifrs-full_FinancialInstrumentsMeasuredAtFairValueThroughProfitOrLossBecauseCreditDerivativeIsUsedToManageCreditRiskMember" order="0.0"/>
    <loc xlink:type="locator" xlink:label="LessThanThreeMonthMember" xlink:href="tlsa-20221231.xsd#tlsa_LessThanThreeMonthMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_FinancialInstrumentsMeasuredAtFairValueThroughProfitOrLossBecauseCreditDerivativeIsUsedToManageCreditRiskAxis" xlink:to="LessThanThreeMonthMember" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ThreeToTwelveMonthMember" xlink:href="tlsa-20221231.xsd#tlsa_ThreeToTwelveMonthMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_FinancialInstrumentsMeasuredAtFairValueThroughProfitOrLossBecauseCreditDerivativeIsUsedToManageCreditRiskAxis" xlink:to="ThreeToTwelveMonthMember" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="FinancialInstrumentsDetailsScheduleoffinancialliabilitiesbasedoncontractualundiscountedpaymentsTable" xlink:to="FinancialInstrumentsDetailsScheduleoffinancialliabilitiesbasedoncontractualundiscountedpaymentsLineItems" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_TradeAndOtherPayables" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TradeAndOtherPayables"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="FinancialInstrumentsDetailsScheduleoffinancialliabilitiesbasedoncontractualundiscountedpaymentsLineItems" xlink:to="ifrs-full_TradeAndOtherPayables" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="LeaseLiabilities1" xlink:href="tlsa-20221231.xsd#tlsa_LeaseLiabilities1"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="FinancialInstrumentsDetailsScheduleoffinancialliabilitiesbasedoncontractualundiscountedpaymentsLineItems" xlink:to="LeaseLiabilities1" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="RelatedPartyPayablesAmount" xlink:href="tlsa-20221231.xsd#tlsa_RelatedPartyPayablesAmount"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="FinancialInstrumentsDetailsScheduleoffinancialliabilitiesbasedoncontractualundiscountedpaymentsLineItems" xlink:to="RelatedPartyPayablesAmount" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="FinancialInstrumentsNet" xlink:href="tlsa-20221231.xsd#tlsa_FinancialInstrumentsNet"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="FinancialInstrumentsDetailsScheduleoffinancialliabilitiesbasedoncontractualundiscountedpaymentsLineItems" xlink:to="FinancialInstrumentsNet" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ScheduleofmeasurementofthefinancialinstrumentsdenominatedinaforeigncurrencyandaffectedequityandprofitandlossbytheamountsTable">
    <loc xlink:type="locator" xlink:label="ScheduleOfMeasurementOfTheFinancialInstrumentsDenominatedInAForeignCurrencyAndAffectedEquityAndProfitAndLossByTheAmountsAbstract" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfMeasurementOfTheFinancialInstrumentsDenominatedInAForeignCurrencyAndAffectedEquityAndProfitAndLossByTheAmountsAbstract"/>
    <loc xlink:type="locator" xlink:label="FinancialInstrumentsDetailsScheduleofmeasurementofthefinancialinstrumentsdenominatedinaforeigncurrencyandaffectedequityandprofitandlossbytheamountsTable" xlink:href="tlsa-20221231.xsd#tlsa_FinancialInstrumentsDetailsScheduleofmeasurementofthefinancialinstrumentsdenominatedinaforeigncurrencyandaffectedequityandprofitandlossbytheamountsTable"/>
    <loc xlink:type="locator" xlink:label="FinancialInstrumentsDetailsScheduleofmeasurementofthefinancialinstrumentsdenominatedinaforeigncurrencyandaffectedequityandprofitandlossbytheamountsLineItems" xlink:href="tlsa-20221231.xsd#tlsa_FinancialInstrumentsDetailsScheduleofmeasurementofthefinancialinstrumentsdenominatedinaforeigncurrencyandaffectedequityandprofitandlossbytheamountsLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfMeasurementOfTheFinancialInstrumentsDenominatedInAForeignCurrencyAndAffectedEquityAndProfitAndLossByTheAmountsAbstract" xlink:to="FinancialInstrumentsDetailsScheduleofmeasurementofthefinancialinstrumentsdenominatedinaforeigncurrencyandaffectedequityandprofitandlossbytheamountsTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="srt_CurrencyAxis" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CurrencyAxis"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="FinancialInstrumentsDetailsScheduleofmeasurementofthefinancialinstrumentsdenominatedinaforeigncurrencyandaffectedequityandprofitandlossbytheamountsTable" xlink:to="srt_CurrencyAxis" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="USDMember" xlink:href="tlsa-20221231.xsd#tlsa_USDMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="srt_CurrencyAxis" xlink:to="USDMember" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="FinancialInstrumentsDetailsScheduleofmeasurementofthefinancialinstrumentsdenominatedinaforeigncurrencyandaffectedequityandprofitandlossbytheamountsTable" xlink:to="FinancialInstrumentsDetailsScheduleofmeasurementofthefinancialinstrumentsdenominatedinaforeigncurrencyandaffectedequityandprofitandlossbytheamountsLineItems" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ProfitOrLossAndEquityStrengthening" xlink:href="tlsa-20221231.xsd#tlsa_ProfitOrLossAndEquityStrengthening"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="FinancialInstrumentsDetailsScheduleofmeasurementofthefinancialinstrumentsdenominatedinaforeigncurrencyandaffectedequityandprofitandlossbytheamountsLineItems" xlink:to="ProfitOrLossAndEquityStrengthening" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ProfitOrLossAndEquityWeakening" xlink:href="tlsa-20221231.xsd#tlsa_ProfitOrLossAndEquityWeakening"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="FinancialInstrumentsDetailsScheduleofmeasurementofthefinancialinstrumentsdenominatedinaforeigncurrencyandaffectedequityandprofitandlossbytheamountsLineItems" xlink:to="ProfitOrLossAndEquityWeakening" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ScheduleofmeasurementofthefinancialinstrumentsdenominatedinaforeigncurrencyandaffectedequityandprofitandlossbytheamountsTable_Parentheticals">
    <loc xlink:type="locator" xlink:label="ScheduleOfMeasurementOfTheFinancialInstrumentsDenominatedInAForeignCurrencyAndAffectedEquityAndProfitAndLossByTheAmountsAbstract" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfMeasurementOfTheFinancialInstrumentsDenominatedInAForeignCurrencyAndAffectedEquityAndProfitAndLossByTheAmountsAbstract"/>
    <loc xlink:type="locator" xlink:label="FinancialInstrumentsDetailsScheduleofmeasurementofthefinancialinstrumentsdenominatedinaforeigncurrencyandaffectedequityandprofitandlossbytheamountsParentheticalsTable" xlink:href="tlsa-20221231.xsd#tlsa_FinancialInstrumentsDetailsScheduleofmeasurementofthefinancialinstrumentsdenominatedinaforeigncurrencyandaffectedequityandprofitandlossbytheamountsParentheticalsTable"/>
    <loc xlink:type="locator" xlink:label="FinancialInstrumentsDetailsScheduleofmeasurementofthefinancialinstrumentsdenominatedinaforeigncurrencyandaffectedequityandprofitandlossbytheamountsParentheticalsLineItems" xlink:href="tlsa-20221231.xsd#tlsa_FinancialInstrumentsDetailsScheduleofmeasurementofthefinancialinstrumentsdenominatedinaforeigncurrencyandaffectedequityandprofitandlossbytheamountsParentheticalsLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfMeasurementOfTheFinancialInstrumentsDenominatedInAForeignCurrencyAndAffectedEquityAndProfitAndLossByTheAmountsAbstract" xlink:to="FinancialInstrumentsDetailsScheduleofmeasurementofthefinancialinstrumentsdenominatedinaforeigncurrencyandaffectedequityandprofitandlossbytheamountsParentheticalsTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="srt_CurrencyAxis" xlink:href="https://xbrl.fasb.org/srt/2021/elts/srt-2021-01-31.xsd#srt_CurrencyAxis"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="FinancialInstrumentsDetailsScheduleofmeasurementofthefinancialinstrumentsdenominatedinaforeigncurrencyandaffectedequityandprofitandlossbytheamountsParentheticalsTable" xlink:to="srt_CurrencyAxis" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="USDMember" xlink:href="tlsa-20221231.xsd#tlsa_USDMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="srt_CurrencyAxis" xlink:to="USDMember" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="FinancialInstrumentsDetailsScheduleofmeasurementofthefinancialinstrumentsdenominatedinaforeigncurrencyandaffectedequityandprofitandlossbytheamountsParentheticalsTable" xlink:to="FinancialInstrumentsDetailsScheduleofmeasurementofthefinancialinstrumentsdenominatedinaforeigncurrencyandaffectedequityandprofitandlossbytheamountsParentheticalsLineItems" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="MovementPercentageStrengthening" xlink:href="tlsa-20221231.xsd#tlsa_MovementPercentageStrengthening"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="FinancialInstrumentsDetailsScheduleofmeasurementofthefinancialinstrumentsdenominatedinaforeigncurrencyandaffectedequityandprofitandlossbytheamountsParentheticalsLineItems" xlink:to="MovementPercentageStrengthening" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="MovementPercentageWeakening" xlink:href="tlsa-20221231.xsd#tlsa_MovementPercentageWeakening"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="FinancialInstrumentsDetailsScheduleofmeasurementofthefinancialinstrumentsdenominatedinaforeigncurrencyandaffectedequityandprofitandlossbytheamountsParentheticalsLineItems" xlink:to="MovementPercentageWeakening" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ScheduleoftradeandotherpayablesTable">
    <loc xlink:type="locator" xlink:label="ScheduleOfTradeAndOtherPayablesAbstract" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfTradeAndOtherPayablesAbstract"/>
    <loc xlink:type="locator" xlink:label="TradeandOtherPayablesDetailsScheduleoftradeandotherpayablesTable" xlink:href="tlsa-20221231.xsd#tlsa_TradeandOtherPayablesDetailsScheduleoftradeandotherpayablesTable"/>
    <loc xlink:type="locator" xlink:label="TradeandOtherPayablesDetailsScheduleoftradeandotherpayablesLineItems" xlink:href="tlsa-20221231.xsd#tlsa_TradeandOtherPayablesDetailsScheduleoftradeandotherpayablesLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfTradeAndOtherPayablesAbstract" xlink:to="TradeandOtherPayablesDetailsScheduleoftradeandotherpayablesTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_SegmentsAxis" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SegmentsAxis"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="TradeandOtherPayablesDetailsScheduleoftradeandotherpayablesTable" xlink:to="ifrs-full_SegmentsAxis" order="1.0"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_SegmentsMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SegmentsMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_SegmentsAxis" xlink:to="ifrs-full_SegmentsMember" order="0.0"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="TradeandOtherPayablesDetailsScheduleoftradeandotherpayablesTable" xlink:to="TradeandOtherPayablesDetailsScheduleoftradeandotherpayablesLineItems" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_TradeAndOtherPayablesToTradeSuppliers" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TradeAndOtherPayablesToTradeSuppliers"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="TradeandOtherPayablesDetailsScheduleoftradeandotherpayablesLineItems" xlink:to="ifrs-full_TradeAndOtherPayablesToTradeSuppliers" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_AccrualsClassifiedAsCurrent" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AccrualsClassifiedAsCurrent"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="TradeandOtherPayablesDetailsScheduleoftradeandotherpayablesLineItems" xlink:to="ifrs-full_AccrualsClassifiedAsCurrent" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_TradeAndOtherCurrentPayables" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TradeAndOtherCurrentPayables"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="TradeandOtherPayablesDetailsScheduleoftradeandotherpayablesLineItems" xlink:to="ifrs-full_TradeAndOtherCurrentPayables" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ScheduleofinvestmentinrelatedpartyTable">
    <loc xlink:type="locator" xlink:label="ScheduleOfInvestmentInRelatedPartyAbstract" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfInvestmentInRelatedPartyAbstract"/>
    <loc xlink:type="locator" xlink:label="InvestmentinRelatedPartyDetailsScheduleofinvestmentinrelatedpartyTable" xlink:href="tlsa-20221231.xsd#tlsa_InvestmentinRelatedPartyDetailsScheduleofinvestmentinrelatedpartyTable"/>
    <loc xlink:type="locator" xlink:label="InvestmentinRelatedPartyDetailsScheduleofinvestmentinrelatedpartyLineItems" xlink:href="tlsa-20221231.xsd#tlsa_InvestmentinRelatedPartyDetailsScheduleofinvestmentinrelatedpartyLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfInvestmentInRelatedPartyAbstract" xlink:to="InvestmentinRelatedPartyDetailsScheduleofinvestmentinrelatedpartyTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_SegmentsAxis" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SegmentsAxis"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="InvestmentinRelatedPartyDetailsScheduleofinvestmentinrelatedpartyTable" xlink:to="ifrs-full_SegmentsAxis" order="1.0"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_SegmentsMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SegmentsMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_SegmentsAxis" xlink:to="ifrs-full_SegmentsMember" order="0.0"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="InvestmentinRelatedPartyDetailsScheduleofinvestmentinrelatedpartyTable" xlink:to="InvestmentinRelatedPartyDetailsScheduleofinvestmentinrelatedpartyLineItems" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_AdjustmentsForGainsLossesOnFairValueAdjustmentInvestmentProperty" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AdjustmentsForGainsLossesOnFairValueAdjustmentInvestmentProperty"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="InvestmentinRelatedPartyDetailsScheduleofinvestmentinrelatedpartyLineItems" xlink:to="ifrs-full_AdjustmentsForGainsLossesOnFairValueAdjustmentInvestmentProperty" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ImpairmentLossOnFinancialAssets" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ImpairmentLossOnFinancialAssets"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="InvestmentinRelatedPartyDetailsScheduleofinvestmentinrelatedpartyLineItems" xlink:to="ifrs-full_ImpairmentLossOnFinancialAssets" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ImpairmentLossRecognisedInProfitOrLossInvestmentProperty" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ImpairmentLossRecognisedInProfitOrLossInvestmentProperty"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="InvestmentinRelatedPartyDetailsScheduleofinvestmentinrelatedpartyLineItems" xlink:to="ifrs-full_ImpairmentLossRecognisedInProfitOrLossInvestmentProperty" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ScheduleofrightofuseassetsandleaseliabilitiesTable">
    <loc xlink:type="locator" xlink:label="ScheduleOfRightOfUseAssetsAndLeaseLiabilitiesAbstract" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfRightOfUseAssetsAndLeaseLiabilitiesAbstract"/>
    <loc xlink:type="locator" xlink:label="LeasesDetailsScheduleofrightofuseassetsandleaseliabilitiesTable" xlink:href="tlsa-20221231.xsd#tlsa_LeasesDetailsScheduleofrightofuseassetsandleaseliabilitiesTable"/>
    <loc xlink:type="locator" xlink:label="LeasesDetailsScheduleofrightofuseassetsandleaseliabilitiesLineItems" xlink:href="tlsa-20221231.xsd#tlsa_LeasesDetailsScheduleofrightofuseassetsandleaseliabilitiesLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfRightOfUseAssetsAndLeaseLiabilitiesAbstract" xlink:to="LeasesDetailsScheduleofrightofuseassetsandleaseliabilitiesTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_SegmentsAxis" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SegmentsAxis"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LeasesDetailsScheduleofrightofuseassetsandleaseliabilitiesTable" xlink:to="ifrs-full_SegmentsAxis" order="1.0"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_SegmentsMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SegmentsMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_SegmentsAxis" xlink:to="ifrs-full_SegmentsMember" order="0.0"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LeasesDetailsScheduleofrightofuseassetsandleaseliabilitiesTable" xlink:to="LeasesDetailsScheduleofrightofuseassetsandleaseliabilitiesLineItems" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="RightOfUseAssetBeginning" xlink:href="tlsa-20221231.xsd#tlsa_RightOfUseAssetBeginning"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LeasesDetailsScheduleofrightofuseassetsandleaseliabilitiesLineItems" xlink:to="RightOfUseAssetBeginning" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="RightOfUseAssetsDepreciation" xlink:href="tlsa-20221231.xsd#tlsa_RightOfUseAssetsDepreciation"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LeasesDetailsScheduleofrightofuseassetsandleaseliabilitiesLineItems" xlink:to="RightOfUseAssetsDepreciation" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="DisposalOfLeaseRightofUseAssets" xlink:href="tlsa-20221231.xsd#tlsa_DisposalOfLeaseRightofUseAssets"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LeasesDetailsScheduleofrightofuseassetsandleaseliabilitiesLineItems" xlink:to="DisposalOfLeaseRightofUseAssets" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ExchangeDifferencesRightofUseAssets" xlink:href="tlsa-20221231.xsd#tlsa_ExchangeDifferencesRightofUseAssets"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LeasesDetailsScheduleofrightofuseassetsandleaseliabilitiesLineItems" xlink:to="ExchangeDifferencesRightofUseAssets" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="RightOfUseAssetsTotal" xlink:href="tlsa-20221231.xsd#tlsa_RightOfUseAssetsTotal"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LeasesDetailsScheduleofrightofuseassetsandleaseliabilitiesLineItems" xlink:to="RightOfUseAssetsTotal" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="LeaseLiabilitiesBeginning" xlink:href="tlsa-20221231.xsd#tlsa_LeaseLiabilitiesBeginning"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LeasesDetailsScheduleofrightofuseassetsandleaseliabilitiesLineItems" xlink:to="LeaseLiabilitiesBeginning" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="LeaseLiabilitiesInterestExpense" xlink:href="tlsa-20221231.xsd#tlsa_LeaseLiabilitiesInterestExpense"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LeasesDetailsScheduleofrightofuseassetsandleaseliabilitiesLineItems" xlink:to="LeaseLiabilitiesInterestExpense" order="6.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="LeaseLiabilitiesLeasePayments" xlink:href="tlsa-20221231.xsd#tlsa_LeaseLiabilitiesLeasePayments"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LeasesDetailsScheduleofrightofuseassetsandleaseliabilitiesLineItems" xlink:to="LeaseLiabilitiesLeasePayments" order="7.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ExchangeDifferences" xlink:href="tlsa-20221231.xsd#tlsa_ExchangeDifferences"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LeasesDetailsScheduleofrightofuseassetsandleaseliabilitiesLineItems" xlink:to="ExchangeDifferences" order="8.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="DisposalOfLease" xlink:href="tlsa-20221231.xsd#tlsa_DisposalOfLease"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LeasesDetailsScheduleofrightofuseassetsandleaseliabilitiesLineItems" xlink:to="DisposalOfLease" order="9.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="LeaseLiabilitiesTotal" xlink:href="tlsa-20221231.xsd#tlsa_LeaseLiabilitiesTotal"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LeasesDetailsScheduleofrightofuseassetsandleaseliabilitiesLineItems" xlink:to="LeaseLiabilitiesTotal" order="10.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ScheduleofconsolidatedstatementoffinancialTable">
    <loc xlink:type="locator" xlink:label="ScheduleOfConsolidatedStatementOfFinancialAbstract" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfConsolidatedStatementOfFinancialAbstract"/>
    <loc xlink:type="locator" xlink:label="LeasesDetailsScheduleofconsolidatedstatementoffinancialTable" xlink:href="tlsa-20221231.xsd#tlsa_LeasesDetailsScheduleofconsolidatedstatementoffinancialTable"/>
    <loc xlink:type="locator" xlink:label="LeasesDetailsScheduleofconsolidatedstatementoffinancialLineItems" xlink:href="tlsa-20221231.xsd#tlsa_LeasesDetailsScheduleofconsolidatedstatementoffinancialLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfConsolidatedStatementOfFinancialAbstract" xlink:to="LeasesDetailsScheduleofconsolidatedstatementoffinancialTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_SegmentsAxis" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SegmentsAxis"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LeasesDetailsScheduleofconsolidatedstatementoffinancialTable" xlink:to="ifrs-full_SegmentsAxis" order="1.0"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_SegmentsMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SegmentsMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_SegmentsAxis" xlink:to="ifrs-full_SegmentsMember" order="0.0"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LeasesDetailsScheduleofconsolidatedstatementoffinancialTable" xlink:to="LeasesDetailsScheduleofconsolidatedstatementoffinancialLineItems" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_CurrentLeaseLiabilities" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentLeaseLiabilities"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LeasesDetailsScheduleofconsolidatedstatementoffinancialLineItems" xlink:to="ifrs-full_CurrentLeaseLiabilities" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_NoncurrentLeaseLiabilities" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NoncurrentLeaseLiabilities"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LeasesDetailsScheduleofconsolidatedstatementoffinancialLineItems" xlink:to="ifrs-full_NoncurrentLeaseLiabilities" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_LeaseLiabilities" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_LeaseLiabilities"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LeasesDetailsScheduleofconsolidatedstatementoffinancialLineItems" xlink:to="ifrs-full_LeaseLiabilities" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ScheduleoffutureminimumleasepaymentsTable">
    <loc xlink:type="locator" xlink:label="ScheduleOfFutureMinimumLeasePaymentsAbstract" xlink:href="tlsa-20221231.xsd#tlsa_ScheduleOfFutureMinimumLeasePaymentsAbstract"/>
    <loc xlink:type="locator" xlink:label="LeasesDetailsScheduleoffutureminimumleasepaymentsTable" xlink:href="tlsa-20221231.xsd#tlsa_LeasesDetailsScheduleoffutureminimumleasepaymentsTable"/>
    <loc xlink:type="locator" xlink:label="LeasesDetailsScheduleoffutureminimumleasepaymentsLineItems" xlink:href="tlsa-20221231.xsd#tlsa_LeasesDetailsScheduleoffutureminimumleasepaymentsLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ScheduleOfFutureMinimumLeasePaymentsAbstract" xlink:to="LeasesDetailsScheduleoffutureminimumleasepaymentsTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_MaturityAxis" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_MaturityAxis"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LeasesDetailsScheduleoffutureminimumleasepaymentsTable" xlink:to="ifrs-full_MaturityAxis" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_AggregatedTimeBandsMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_AggregatedTimeBandsMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_MaturityAxis" xlink:to="ifrs-full_AggregatedTimeBandsMember" order="0.0"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_NotLaterThanOneYearMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NotLaterThanOneYearMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_MaturityAxis" xlink:to="ifrs-full_NotLaterThanOneYearMember" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_LaterThanOneYearAndNotLaterThanTwoYearsMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_LaterThanOneYearAndNotLaterThanTwoYearsMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_MaturityAxis" xlink:to="ifrs-full_LaterThanOneYearAndNotLaterThanTwoYearsMember" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="LaterThanTwoYearsAndNotLaterThanFiveYearMember" xlink:href="tlsa-20221231.xsd#tlsa_LaterThanTwoYearsAndNotLaterThanFiveYearMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_MaturityAxis" xlink:to="LaterThanTwoYearsAndNotLaterThanFiveYearMember" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_LaterThanFiveYearsMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_LaterThanFiveYearsMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_MaturityAxis" xlink:to="ifrs-full_LaterThanFiveYearsMember" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LeasesDetailsScheduleoffutureminimumleasepaymentsTable" xlink:to="LeasesDetailsScheduleoffutureminimumleasepaymentsLineItems" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="LeasePayments" xlink:href="tlsa-20221231.xsd#tlsa_LeasePayments"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LeasesDetailsScheduleoffutureminimumleasepaymentsLineItems" xlink:to="LeasePayments" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="FinanceCharges" xlink:href="tlsa-20221231.xsd#tlsa_FinanceCharges"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LeasesDetailsScheduleoffutureminimumleasepaymentsLineItems" xlink:to="FinanceCharges" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="NetPresentValues" xlink:href="tlsa-20221231.xsd#tlsa_NetPresentValues"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="LeasesDetailsScheduleoffutureminimumleasepaymentsLineItems" xlink:to="NetPresentValues" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/AccountingPoliciesDetails">
    <loc xlink:type="locator" xlink:label="DisclosureOfSignificantAccountingPoliciesTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfSignificantAccountingPoliciesTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="AccountingPoliciesDetailsTable" xlink:href="tlsa-20221231.xsd#tlsa_AccountingPoliciesDetailsTable"/>
    <loc xlink:type="locator" xlink:label="AccountingPoliciesDetailsLineItems" xlink:href="tlsa-20221231.xsd#tlsa_AccountingPoliciesDetailsLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfSignificantAccountingPoliciesTextBlockAbstract" xlink:to="AccountingPoliciesDetailsTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="AccountingPoliciesDetailsTable" xlink:to="AccountingPoliciesDetailsLineItems" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="CashSurplus" xlink:href="tlsa-20221231.xsd#tlsa_CashSurplus"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="AccountingPoliciesDetailsLineItems" xlink:to="CashSurplus" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="NumberOfSegment" xlink:href="tlsa-20221231.xsd#tlsa_NumberOfSegment"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="AccountingPoliciesDetailsLineItems" xlink:to="NumberOfSegment" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="UpfrontPayment" xlink:href="tlsa-20221231.xsd#tlsa_UpfrontPayment"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="AccountingPoliciesDetailsLineItems" xlink:to="UpfrontPayment" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/OperatingLossDetails">
    <loc xlink:type="locator" xlink:label="DisclosureOfProfitLossFromOperatingActivitiesTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfProfitLossFromOperatingActivitiesTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="OperatingLossDetailsTable" xlink:href="tlsa-20221231.xsd#tlsa_OperatingLossDetailsTable"/>
    <loc xlink:type="locator" xlink:label="OperatingLossDetailsLineItems" xlink:href="tlsa-20221231.xsd#tlsa_OperatingLossDetailsLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfProfitLossFromOperatingActivitiesTextBlockAbstract" xlink:to="OperatingLossDetailsTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OperatingLossDetailsTable" xlink:to="OperatingLossDetailsLineItems" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_BenefitsPaidOrPayable" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_BenefitsPaidOrPayable"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OperatingLossDetailsLineItems" xlink:to="ifrs-full_BenefitsPaidOrPayable" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="RaisingFunds" xlink:href="tlsa-20221231.xsd#tlsa_RaisingFunds"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OperatingLossDetailsLineItems" xlink:to="RaisingFunds" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_CurrentAccruedExpensesAndOtherCurrentLiabilities" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentAccruedExpensesAndOtherCurrentLiabilities"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="OperatingLossDetailsLineItems" xlink:to="ifrs-full_CurrentAccruedExpensesAndOtherCurrentLiabilities" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/RemunerationofKeyManagementPersonnelDetails">
    <loc xlink:type="locator" xlink:label="DisclosureOfInformationAboutKeyManagementPersonnelTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfInformationAboutKeyManagementPersonnelTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="RemunerationofKeyManagementPersonnelDetailsTable" xlink:href="tlsa-20221231.xsd#tlsa_RemunerationofKeyManagementPersonnelDetailsTable"/>
    <loc xlink:type="locator" xlink:label="RemunerationofKeyManagementPersonnelDetailsLineItems" xlink:href="tlsa-20221231.xsd#tlsa_RemunerationofKeyManagementPersonnelDetailsLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfInformationAboutKeyManagementPersonnelTextBlockAbstract" xlink:to="RemunerationofKeyManagementPersonnelDetailsTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RemunerationofKeyManagementPersonnelDetailsTable" xlink:to="RemunerationofKeyManagementPersonnelDetailsLineItems" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="GabrieleCerronesBonusDescription" xlink:href="tlsa-20221231.xsd#tlsa_GabrieleCerronesBonusDescription"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RemunerationofKeyManagementPersonnelDetailsLineItems" xlink:to="GabrieleCerronesBonusDescription" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ExercisedSharesOptions" xlink:href="tlsa-20221231.xsd#tlsa_ExercisedSharesOptions"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RemunerationofKeyManagementPersonnelDetailsLineItems" xlink:to="ExercisedSharesOptions" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="intrinsicGain" xlink:href="tlsa-20221231.xsd#tlsa_intrinsicGain"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RemunerationofKeyManagementPersonnelDetailsLineItems" xlink:to="intrinsicGain" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_PostemploymentBenefitExpenseDefinedContributionPlans" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PostemploymentBenefitExpenseDefinedContributionPlans"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RemunerationofKeyManagementPersonnelDetailsLineItems" xlink:to="ifrs-full_PostemploymentBenefitExpenseDefinedContributionPlans" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/TaxationDetails">
    <loc xlink:type="locator" xlink:label="DisclosureOfIncomeTaxTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfIncomeTaxTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="TaxationDetailsTable" xlink:href="tlsa-20221231.xsd#tlsa_TaxationDetailsTable"/>
    <loc xlink:type="locator" xlink:label="TaxationDetailsLineItems" xlink:href="tlsa-20221231.xsd#tlsa_TaxationDetailsLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfIncomeTaxTextBlockAbstract" xlink:to="TaxationDetailsTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="TaxationDetailsTable" xlink:to="TaxationDetailsLineItems" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="MaximumPercentageOfSurrenderableLosses" xlink:href="tlsa-20221231.xsd#tlsa_MaximumPercentageOfSurrenderableLosses"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="TaxationDetailsLineItems" xlink:to="MaximumPercentageOfSurrenderableLosses" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="TermOfResearchAndDevelopmentTaxReliefClaims" xlink:href="tlsa-20221231.xsd#tlsa_TermOfResearchAndDevelopmentTaxReliefClaims"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="TaxationDetailsLineItems" xlink:to="TermOfResearchAndDevelopmentTaxReliefClaims" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_TaxEffectOfTaxLosses" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TaxEffectOfTaxLosses"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="TaxationDetailsLineItems" xlink:to="ifrs-full_TaxEffectOfTaxLosses" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ShareCapitalandSharePremiumDetails">
    <loc xlink:type="locator" xlink:label="DisclosureOfShareCapitalReservesAndOtherEquityInterestTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfShareCapitalReservesAndOtherEquityInterestTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="ShareCapitalandSharePremiumDetailsTable" xlink:href="tlsa-20221231.xsd#tlsa_ShareCapitalandSharePremiumDetailsTable"/>
    <loc xlink:type="locator" xlink:label="ShareCapitalandSharePremiumDetailsLineItems" xlink:href="tlsa-20221231.xsd#tlsa_ShareCapitalandSharePremiumDetailsLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfShareCapitalReservesAndOtherEquityInterestTextBlockAbstract" xlink:to="ShareCapitalandSharePremiumDetailsTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ClassesOfShareCapitalAxis" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ClassesOfShareCapitalAxis"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareCapitalandSharePremiumDetailsTable" xlink:to="ifrs-full_ClassesOfShareCapitalAxis" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ClassesOfShareCapitalMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ClassesOfShareCapitalMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_ClassesOfShareCapitalAxis" xlink:to="ifrs-full_ClassesOfShareCapitalMember" order="0.0"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_OrdinarySharesMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OrdinarySharesMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_ClassesOfShareCapitalAxis" xlink:to="ifrs-full_OrdinarySharesMember" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareCapitalandSharePremiumDetailsTable" xlink:to="ShareCapitalandSharePremiumDetailsLineItems" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ParValuePerShare" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ParValuePerShare"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareCapitalandSharePremiumDetailsLineItems" xlink:to="ifrs-full_ParValuePerShare" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_SharesInEntityHeldByEntityOrByItsSubsidiariesOrAssociates" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_SharesInEntityHeldByEntityOrByItsSubsidiariesOrAssociates"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareCapitalandSharePremiumDetailsLineItems" xlink:to="ifrs-full_SharesInEntityHeldByEntityOrByItsSubsidiariesOrAssociates" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="NumberOfSharesIssued1" xlink:href="tlsa-20221231.xsd#tlsa_NumberOfSharesIssued1"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareCapitalandSharePremiumDetailsLineItems" xlink:to="NumberOfSharesIssued1" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="TreasuryShares1" xlink:href="tlsa-20221231.xsd#tlsa_TreasuryShares1"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareCapitalandSharePremiumDetailsLineItems" xlink:to="TreasuryShares1" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/ShareBasedPaymentsDetails">
    <loc xlink:type="locator" xlink:label="DisclosureOfShareBasedPaymentArrangementsTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfShareBasedPaymentArrangementsTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="ShareBasedPaymentsDetailsTable" xlink:href="tlsa-20221231.xsd#tlsa_ShareBasedPaymentsDetailsTable"/>
    <loc xlink:type="locator" xlink:label="ShareBasedPaymentsDetailsLineItems" xlink:href="tlsa-20221231.xsd#tlsa_ShareBasedPaymentsDetailsLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfShareBasedPaymentArrangementsTextBlockAbstract" xlink:to="ShareBasedPaymentsDetailsTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ClassesOfFinancialInstrumentsAxis" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ClassesOfFinancialInstrumentsAxis"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareBasedPaymentsDetailsTable" xlink:to="ifrs-full_ClassesOfFinancialInstrumentsAxis" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ClassesOfFinancialInstrumentsMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ClassesOfFinancialInstrumentsMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_ClassesOfFinancialInstrumentsAxis" xlink:to="ifrs-full_ClassesOfFinancialInstrumentsMember" order="0.0"/>
    <loc xlink:type="locator" xlink:label="BlackScholesMertonValuationModelMember" xlink:href="tlsa-20221231.xsd#tlsa_BlackScholesMertonValuationModelMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_ClassesOfFinancialInstrumentsAxis" xlink:to="BlackScholesMertonValuationModelMember" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CategoriesOfRelatedPartiesAxis"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareBasedPaymentsDetailsTable" xlink:to="ifrs-full_CategoriesOfRelatedPartiesAxis" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_EntitysTotalForRelatedPartiesMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_EntitysTotalForRelatedPartiesMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:to="ifrs-full_EntitysTotalForRelatedPartiesMember" order="0.0"/>
    <loc xlink:type="locator" xlink:label="TizianaLifeSciencesPLCMember" xlink:href="tlsa-20221231.xsd#tlsa_TizianaLifeSciencesPLCMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:to="TizianaLifeSciencesPLCMember" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareBasedPaymentsDetailsTable" xlink:to="ShareBasedPaymentsDetailsLineItems" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="SharesOfOptionsExercised" xlink:href="tlsa-20221231.xsd#tlsa_SharesOfOptionsExercised"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareBasedPaymentsDetailsLineItems" xlink:to="SharesOfOptionsExercised" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="OutstandingFairValueCharges" xlink:href="tlsa-20221231.xsd#tlsa_OutstandingFairValueCharges"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareBasedPaymentsDetailsLineItems" xlink:to="OutstandingFairValueCharges" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ExpenseFromSharebasedPaymentTransactionsWithPartiesOtherThanEmployees" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ExpenseFromSharebasedPaymentTransactionsWithPartiesOtherThanEmployees"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareBasedPaymentsDetailsLineItems" xlink:to="ifrs-full_ExpenseFromSharebasedPaymentTransactionsWithPartiesOtherThanEmployees" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ExpectedTermOfAwards" xlink:href="tlsa-20221231.xsd#tlsa_ExpectedTermOfAwards"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareBasedPaymentsDetailsLineItems" xlink:to="ExpectedTermOfAwards" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ExercisePriceOfOutstandingShareOptions2019" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ExercisePriceOfOutstandingShareOptions2019"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareBasedPaymentsDetailsLineItems" xlink:to="ifrs-full_ExercisePriceOfOutstandingShareOptions2019" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="TotalExpenses" xlink:href="tlsa-20221231.xsd#tlsa_TotalExpenses"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareBasedPaymentsDetailsLineItems" xlink:to="TotalExpenses" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="SharebasedPaymentCharge" xlink:href="tlsa-20221231.xsd#tlsa_SharebasedPaymentCharge"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ShareBasedPaymentsDetailsLineItems" xlink:to="SharebasedPaymentCharge" order="6.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/InvestmentinRelatedPartyDetails">
    <loc xlink:type="locator" xlink:label="InvestmentInRelatedPartyAbstract" xlink:href="tlsa-20221231.xsd#tlsa_InvestmentInRelatedPartyAbstract"/>
    <loc xlink:type="locator" xlink:label="CommonStockShares" xlink:href="tlsa-20221231.xsd#tlsa_CommonStockShares"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="InvestmentInRelatedPartyAbstract" xlink:to="CommonStockShares" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_DividendsPaidOtherSharesPerShare" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_DividendsPaidOtherSharesPerShare"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="InvestmentInRelatedPartyAbstract" xlink:to="ifrs-full_DividendsPaidOtherSharesPerShare" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="AggregatePurchasePrice" xlink:href="tlsa-20221231.xsd#tlsa_AggregatePurchasePrice"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="InvestmentInRelatedPartyAbstract" xlink:to="AggregatePurchasePrice" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_PurchasesOfGoodsRelatedPartyTransactions" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_PurchasesOfGoodsRelatedPartyTransactions"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="InvestmentInRelatedPartyAbstract" xlink:to="ifrs-full_PurchasesOfGoodsRelatedPartyTransactions" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="SharesPrice" xlink:href="tlsa-20221231.xsd#tlsa_SharesPrice"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="InvestmentInRelatedPartyAbstract" xlink:to="SharesPrice" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_InsuranceFinanceIncomeExpenses" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_InsuranceFinanceIncomeExpenses"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="InvestmentInRelatedPartyAbstract" xlink:to="ifrs-full_InsuranceFinanceIncomeExpenses" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/TreasurySharesDetails">
    <loc xlink:type="locator" xlink:label="DisclosureOfTreasurySharesTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfTreasurySharesTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="TreasurySharesDetailsTable" xlink:href="tlsa-20221231.xsd#tlsa_TreasurySharesDetailsTable"/>
    <loc xlink:type="locator" xlink:label="TreasurySharesDetailsLineItems" xlink:href="tlsa-20221231.xsd#tlsa_TreasurySharesDetailsLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfTreasurySharesTextBlockAbstract" xlink:to="TreasurySharesDetailsTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ClassOfWarrantsOrRightAxis" xlink:href="tlsa-20221231.xsd#tlsa_ClassOfWarrantsOrRightAxis"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="TreasurySharesDetailsTable" xlink:to="ClassOfWarrantsOrRightAxis" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ClassOfWarrantsOrRightDomain" xlink:href="tlsa-20221231.xsd#tlsa_ClassOfWarrantsOrRightDomain"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ClassOfWarrantsOrRightAxis" xlink:to="ClassOfWarrantsOrRightDomain" order="0.0"/>
    <loc xlink:type="locator" xlink:label="NASDAQStockExchangeMember" xlink:href="tlsa-20221231.xsd#tlsa_NASDAQStockExchangeMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ClassOfWarrantsOrRightAxis" xlink:to="NASDAQStockExchangeMember" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="TreasurySharesDetailsTable" xlink:to="TreasurySharesDetailsLineItems" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="SharesPurchases" xlink:href="tlsa-20221231.xsd#tlsa_SharesPurchases"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="TreasurySharesDetailsLineItems" xlink:to="SharesPurchases" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_TreasuryShares" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_TreasuryShares"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="TreasurySharesDetailsLineItems" xlink:to="ifrs-full_TreasuryShares" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/RelatedPartyTransactionsDetails">
    <loc xlink:type="locator" xlink:label="DisclosureOfRelatedPartyTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfRelatedPartyTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="RelatedPartyTransactionsDetailsTable" xlink:href="tlsa-20221231.xsd#tlsa_RelatedPartyTransactionsDetailsTable"/>
    <loc xlink:type="locator" xlink:label="RelatedPartyTransactionsDetailsLineItems" xlink:href="tlsa-20221231.xsd#tlsa_RelatedPartyTransactionsDetailsLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfRelatedPartyTextBlockAbstract" xlink:to="RelatedPartyTransactionsDetailsTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CategoriesOfRelatedPartiesAxis"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionsDetailsTable" xlink:to="ifrs-full_CategoriesOfRelatedPartiesAxis" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_EntitysTotalForRelatedPartiesMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_EntitysTotalForRelatedPartiesMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:to="ifrs-full_EntitysTotalForRelatedPartiesMember" order="0.0"/>
    <loc xlink:type="locator" xlink:label="OKYOPharmaLtdMember" xlink:href="tlsa-20221231.xsd#tlsa_OKYOPharmaLtdMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_CategoriesOfRelatedPartiesAxis" xlink:to="OKYOPharmaLtdMember" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="RelatedPartyAxis" xlink:href="tlsa-20221231.xsd#tlsa_RelatedPartyAxis"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionsDetailsTable" xlink:to="RelatedPartyAxis" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="RelatedParty_Domain" xlink:href="tlsa-20221231.xsd#tlsa_RelatedParty_Domain"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyAxis" xlink:to="RelatedParty_Domain" order="0.0"/>
    <loc xlink:type="locator" xlink:label="RasnaTherapeuticsIncMember" xlink:href="tlsa-20221231.xsd#tlsa_RasnaTherapeuticsIncMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyAxis" xlink:to="RasnaTherapeuticsIncMember" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="OKYOPharmaLtdMember_0" xlink:href="tlsa-20221231.xsd#tlsa_OKYOPharmaLtdMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyAxis" xlink:to="OKYOPharmaLtdMember_0" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="GensigniaLifesceinecsIncMember" xlink:href="tlsa-20221231.xsd#tlsa_GensigniaLifesceinecsIncMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyAxis" xlink:to="GensigniaLifesceinecsIncMember" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionsDetailsTable" xlink:to="RelatedPartyTransactionsDetailsLineItems" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="InterestAmount" xlink:href="tlsa-20221231.xsd#tlsa_InterestAmount"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionsDetailsLineItems" xlink:to="InterestAmount" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ShortTermLoanFacility1" xlink:href="tlsa-20221231.xsd#tlsa_ShortTermLoanFacility1"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionsDetailsLineItems" xlink:to="ShortTermLoanFacility1" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="PayrollAndRentCharged" xlink:href="tlsa-20221231.xsd#tlsa_PayrollAndRentCharged"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionsDetailsLineItems" xlink:to="PayrollAndRentCharged" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ServicesAgreementAmount" xlink:href="tlsa-20221231.xsd#tlsa_ServicesAgreementAmount"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionsDetailsLineItems" xlink:to="ServicesAgreementAmount" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="InitialAmount" xlink:href="tlsa-20221231.xsd#tlsa_InitialAmount"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionsDetailsLineItems" xlink:to="InitialAmount" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="AdditionalPayment" xlink:href="tlsa-20221231.xsd#tlsa_AdditionalPayment"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionsDetailsLineItems" xlink:to="AdditionalPayment" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ShareIssueRelatedCost" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ShareIssueRelatedCost"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionsDetailsLineItems" xlink:to="ifrs-full_ShareIssueRelatedCost" order="6.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_BorrowingsInterestRate" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_BorrowingsInterestRate"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionsDetailsLineItems" xlink:to="ifrs-full_BorrowingsInterestRate" order="7.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_LoansReceived" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_LoansReceived"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionsDetailsLineItems" xlink:to="ifrs-full_LoansReceived" order="8.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_OtherEquityInterest" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherEquityInterest"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionsDetailsLineItems" xlink:to="ifrs-full_OtherEquityInterest" order="9.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_ExpenseRecognisedDuringPeriodForBadAndDoubtfulDebtsForRelatedPartyTransaction" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_ExpenseRecognisedDuringPeriodForBadAndDoubtfulDebtsForRelatedPartyTransaction"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionsDetailsLineItems" xlink:to="ifrs-full_ExpenseRecognisedDuringPeriodForBadAndDoubtfulDebtsForRelatedPartyTransaction" order="10.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="IrrecoverableAmount" xlink:href="tlsa-20221231.xsd#tlsa_IrrecoverableAmount"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionsDetailsLineItems" xlink:to="IrrecoverableAmount" order="11.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_CostOfSalesRoomOccupancyServices" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CostOfSalesRoomOccupancyServices"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="RelatedPartyTransactionsDetailsLineItems" xlink:to="ifrs-full_CostOfSalesRoomOccupancyServices" order="12.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/LeasesDetails">
    <loc xlink:type="locator" xlink:label="DisclosureOfLeasesTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfLeasesTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_CashOutflowForLeases" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CashOutflowForLeases"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfLeasesTextBlockAbstract" xlink:to="ifrs-full_CashOutflowForLeases" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/FinancialCommitmentsDetails">
    <loc xlink:type="locator" xlink:label="DisclosureOfCommitmentsTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfCommitmentsTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="FinancialCommitmentsDescription" xlink:href="tlsa-20221231.xsd#tlsa_FinancialCommitmentsDescription"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfCommitmentsTextBlockAbstract" xlink:to="FinancialCommitmentsDescription" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="AccruedOfDiligenceObligations" xlink:href="tlsa-20221231.xsd#tlsa_AccruedOfDiligenceObligations"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfCommitmentsTextBlockAbstract" xlink:to="AccruedOfDiligenceObligations" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="DevelopmentMilestonesDescription" xlink:href="tlsa-20221231.xsd#tlsa_DevelopmentMilestonesDescription"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfCommitmentsTextBlockAbstract" xlink:to="DevelopmentMilestonesDescription" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="MilestonePayments" xlink:href="tlsa-20221231.xsd#tlsa_MilestonePayments"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfCommitmentsTextBlockAbstract" xlink:to="MilestonePayments" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/PostBalanceSheetEventsDetails">
    <loc xlink:type="locator" xlink:label="DisclosureOfEventsAfterReportingPeriodTextBlockAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DisclosureOfEventsAfterReportingPeriodTextBlockAbstract"/>
    <loc xlink:type="locator" xlink:label="PostBalanceSheetEventsDetailsTable" xlink:href="tlsa-20221231.xsd#tlsa_PostBalanceSheetEventsDetailsTable"/>
    <loc xlink:type="locator" xlink:label="PostBalanceSheetEventsDetailsLineItems" xlink:href="tlsa-20221231.xsd#tlsa_PostBalanceSheetEventsDetailsLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DisclosureOfEventsAfterReportingPeriodTextBlockAbstract" xlink:to="PostBalanceSheetEventsDetailsTable" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_NonadjustingEventsAfterReportingPeriodAxis" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NonadjustingEventsAfterReportingPeriodAxis"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="PostBalanceSheetEventsDetailsTable" xlink:to="ifrs-full_NonadjustingEventsAfterReportingPeriodAxis" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_NonadjustingEventsMember" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_NonadjustingEventsMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_NonadjustingEventsAfterReportingPeriodAxis" xlink:to="ifrs-full_NonadjustingEventsMember" order="0.0"/>
    <loc xlink:type="locator" xlink:label="NonAdjustingEventsMember" xlink:href="tlsa-20221231.xsd#tlsa_NonAdjustingEventsMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ifrs-full_NonadjustingEventsAfterReportingPeriodAxis" xlink:to="NonAdjustingEventsMember" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="PostBalanceSheetEventsDetailsTable" xlink:to="PostBalanceSheetEventsDetailsLineItems" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="GrantShareOptions" xlink:href="tlsa-20221231.xsd#tlsa_GrantShareOptions"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="PostBalanceSheetEventsDetailsLineItems" xlink:to="GrantShareOptions" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_OtherShorttermEmployeeBenefits" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_OtherShorttermEmployeeBenefits"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="PostBalanceSheetEventsDetailsLineItems" xlink:to="ifrs-full_OtherShorttermEmployeeBenefits" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="ifrs-full_CurrentDebtInstrumentsIssued" xlink:href="http://xbrl.ifrs.org/taxonomy/2021-03-24/full_ifrs/full_ifrs-cor_2021-03-24.xsd#ifrs-full_CurrentDebtInstrumentsIssued"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="PostBalanceSheetEventsDetailsLineItems" xlink:to="ifrs-full_CurrentDebtInstrumentsIssued" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
  <presentationLink xlink:type="extended" xlink:role="http://tizianalifesciences.com/role/DocumentAndEntityInformation">
    <loc xlink:type="locator" xlink:label="DocumentAndEntityInformationAbstract" xlink:href="tlsa-20221231.xsd#tlsa_DocumentAndEntityInformationAbstract"/>
    <loc xlink:type="locator" xlink:label="dei_DocumentInformationTable" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentInformationTable"/>
    <loc xlink:type="locator" xlink:label="dei_DocumentInformationLineItems" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentInformationLineItems"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="DocumentAndEntityInformationAbstract" xlink:to="dei_DocumentInformationTable" order="1.0"/>
    <loc xlink:type="locator" xlink:label="dei_EntityAddressesAddressTypeAxis" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressesAddressTypeAxis"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationTable" xlink:to="dei_EntityAddressesAddressTypeAxis" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <loc xlink:type="locator" xlink:label="dei_AddressTypeDomain" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_AddressTypeDomain"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_EntityAddressesAddressTypeAxis" xlink:to="dei_AddressTypeDomain" order="0.0"/>
    <loc xlink:type="locator" xlink:label="dei_BusinessContactMember" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_BusinessContactMember"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_EntityAddressesAddressTypeAxis" xlink:to="dei_BusinessContactMember" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationTable" xlink:to="dei_DocumentInformationLineItems" order="2.0"/>
    <loc xlink:type="locator" xlink:label="dei_EntityRegistrantName" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityRegistrantName"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_EntityRegistrantName" order="0.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_DocumentType" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentType"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_DocumentType" order="1.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_CurrentFiscalYearEndDate" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_CurrentFiscalYearEndDate"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_CurrentFiscalYearEndDate" order="2.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_EntityCommonStockSharesOutstanding" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_EntityCommonStockSharesOutstanding" order="3.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_AmendmentFlag" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_AmendmentFlag"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_AmendmentFlag" order="4.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_EntityCentralIndexKey" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityCentralIndexKey"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_EntityCentralIndexKey" order="5.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_EntityCurrentReportingStatus" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityCurrentReportingStatus"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_EntityCurrentReportingStatus" order="6.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_EntityVoluntaryFilers" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityVoluntaryFilers"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_EntityVoluntaryFilers" order="7.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_EntityFilerCategory" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityFilerCategory"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_EntityFilerCategory" order="8.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_EntityWellKnownSeasonedIssuer" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityWellKnownSeasonedIssuer"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_EntityWellKnownSeasonedIssuer" order="9.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_DocumentPeriodEndDate" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentPeriodEndDate"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_DocumentPeriodEndDate" order="10.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_DocumentFiscalYearFocus" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentFiscalYearFocus"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_DocumentFiscalYearFocus" order="11.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_DocumentFiscalPeriodFocus" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentFiscalPeriodFocus"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_DocumentFiscalPeriodFocus" order="12.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_EntityEmergingGrowthCompany" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityEmergingGrowthCompany"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_EntityEmergingGrowthCompany" order="13.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_EntityShellCompany" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityShellCompany"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_EntityShellCompany" order="14.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_EntityExTransitionPeriod" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityExTransitionPeriod"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_EntityExTransitionPeriod" order="15.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_DocumentAnnualReport" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentAnnualReport"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_DocumentAnnualReport" order="16.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_DocumentTransitionReport" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentTransitionReport"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_DocumentTransitionReport" order="17.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_DocumentShellCompanyReport" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentShellCompanyReport"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_DocumentShellCompanyReport" order="18.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_EntityIncorporationStateCountryCode" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityIncorporationStateCountryCode"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_EntityIncorporationStateCountryCode" order="19.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_EntityAddressAddressLine1" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressAddressLine1"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_EntityAddressAddressLine1" order="20.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_EntityAddressAddressLine2" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressAddressLine2"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_EntityAddressAddressLine2" order="21.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_EntityAddressCityOrTown" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressCityOrTown"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_EntityAddressCityOrTown" order="22.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_EntityAddressPostalZipCode" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressPostalZipCode"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_EntityAddressPostalZipCode" order="23.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_EntityAddressCountry" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityAddressCountry"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_EntityAddressCountry" order="24.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_ContactPersonnelName" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_ContactPersonnelName"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_ContactPersonnelName" order="25.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_CityAreaCode" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_CityAreaCode"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_CityAreaCode" order="26.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_LocalPhoneNumber" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_LocalPhoneNumber"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_LocalPhoneNumber" order="27.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_EntityInteractiveDataCurrent" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityInteractiveDataCurrent"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_EntityInteractiveDataCurrent" order="28.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_DocumentAccountingStandard" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentAccountingStandard"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_DocumentAccountingStandard" order="29.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_AuditorFirmId" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_AuditorFirmId"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_AuditorFirmId" order="30.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_AuditorName" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_AuditorName"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_AuditorName" order="31.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_AuditorLocation" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_AuditorLocation"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_AuditorLocation" order="32.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_DocumentRegistrationStatement" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_DocumentRegistrationStatement"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_DocumentRegistrationStatement" order="33.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <loc xlink:type="locator" xlink:label="dei_EntityFileNumber" xlink:href="https://xbrl.sec.gov/dei/2021q4/dei-2021q4.xsd#dei_EntityFileNumber"/>
    <presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_DocumentInformationLineItems" xlink:to="dei_EntityFileNumber" order="34.0" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </presentationLink>
</linkbase>
